Galectin-9 suppresses the proliferation of gastric cancer cells in vitro

  • Authors:
    • Jitsuko Takano
    • Asahiro Morishita
    • Shintaro Fujihara
    • Hisakazu Iwama
    • Fuyuko Kokado
    • Keiko Fujikawa
    • Koji Fujita
    • Taiga Chiyo
    • Tomoko Tadokoro
    • Teppei Sakamoto
    • Takako Nomura
    • Joji Tani
    • Hisaaki Miyoshi
    • Hirohito Yoneyama
    • Hideki Kobara
    • Hirohito Mori
    • Toshihiro Niki
    • Mitsuomi Hirashima
    • Tsutomu Masaki
  • View Affiliations

  • Published online on: November 26, 2015     https://doi.org/10.3892/or.2015.4452
  • Pages: 851-860
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Abstract

Gastric cancer is the second-leading cause of cancer-related mortality worldwide, and the prognosis of advanced gastric cancer remains poor. Galectin-9 (Gal-9) is a tandem-repeat-type galectin that has recently been demonstrated to exert anti-proliferative effects on various types of cancer cells. The aim of our present study was to evaluate the effects of Gal-9 on human gastric cancer cells and the expression levels of microRNAs (miRNAs) associated with the antitumor effects of Gal-9 in vitro. In our initial experiments, Gal-9 suppressed the proliferation of gastric cancer cell lines in vitro. Our data further revealed that Gal-9 increased caspase-cleaved keratin 18 (CCK18) levels in gastric cancer cells. Additionally, Gal-9 reduced the phosphorylation of vascular endothelial growth factor receptor-3 (VEGFR-3) and insulin-like growth factor-1 receptor (IGF-1R). Furthermore, miRNA expression levels were markedly altered with Gal-9 treatment in vitro. In conclusion, Gal-9 suppressed the proliferation of human gastric cancer cells by inducing apoptosis. These findings suggest that Gal-9 could be a potential therapeutic target in the treatment of gastric cancer.
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February-2016
Volume 35 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Sakamoto T, et al: Galectin-9 suppresses the proliferation of gastric cancer cells in vitro. Oncol Rep 35: 851-860, 2016.
APA
Takano, J., Morishita, A., Fujihara, S., Iwama, H., Kokado, F., Fujikawa, K. ... Masaki, T. (2016). Galectin-9 suppresses the proliferation of gastric cancer cells in vitro. Oncology Reports, 35, 851-860. https://doi.org/10.3892/or.2015.4452
MLA
Takano, J., Morishita, A., Fujihara, S., Iwama, H., Kokado, F., Fujikawa, K., Fujita, K., Chiyo, T., Tadokoro, T., Sakamoto, T., Nomura, T., Tani, J., Miyoshi, H., Yoneyama, H., Kobara, H., Mori, H., Niki, T., Hirashima, M., Masaki, T."Galectin-9 suppresses the proliferation of gastric cancer cells in vitro". Oncology Reports 35.2 (2016): 851-860.
Chicago
Takano, J., Morishita, A., Fujihara, S., Iwama, H., Kokado, F., Fujikawa, K., Fujita, K., Chiyo, T., Tadokoro, T., Sakamoto, T., Nomura, T., Tani, J., Miyoshi, H., Yoneyama, H., Kobara, H., Mori, H., Niki, T., Hirashima, M., Masaki, T."Galectin-9 suppresses the proliferation of gastric cancer cells in vitro". Oncology Reports 35, no. 2 (2016): 851-860. https://doi.org/10.3892/or.2015.4452