MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration

  • Authors:
    • Hao Xue
    • Xiao Gao
    • Shugang Xu
    • Jinsen Zhang
    • Xing Guo
    • Shaofeng Yan
    • Tong Li
    • Xiaofan Guo
    • Qinglin Liu
    • Gang Li
  • View Affiliations

  • Published online on: January 5, 2016     https://doi.org/10.3892/or.2016.4548
  • Pages: 1771-1777
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was the first to examine the effect of microRNA-Let-7f (miR-Let-7f) inhibiting vasculogenic mimicry (VM) of human glioma cells. The postoperative survival time was significantly poor in VM-positive glioma patients compared with those without VM. Thus, it is reasonable to postulate that miR-Let-7f functions as a potent tumor suppressor by inhibiting glioma VM. However, the molecular mechanisms involved remain poorly clarified. Our preliminary studies revealed that miR-Let-7f suppressed VM by disturbing periostin (POSTN)-induced migration of glioma cells. Our results clearly demonstrated that inhibiting the pro-migratory function of POSTN by the overexpression of miR-Let-7f significantly reduced the formation of VM. Our findings suggest that miR-Let-7f may serve as a potential complementary therapeutic target in the anti‑angiogenesis treatment of gliomas via suppressing VM.
View Figures
View References

Related Articles

Journal Cover

March-2016
Volume 35 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xue H, Gao X, Xu S, Zhang J, Guo X, Yan S, Li T, Guo X, Liu Q, Li G, Li G, et al: MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncol Rep 35: 1771-1777, 2016.
APA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S. ... Li, G. (2016). MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration. Oncology Reports, 35, 1771-1777. https://doi.org/10.3892/or.2016.4548
MLA
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35.3 (2016): 1771-1777.
Chicago
Xue, H., Gao, X., Xu, S., Zhang, J., Guo, X., Yan, S., Li, T., Guo, X., Liu, Q., Li, G."MicroRNA-Let-7f reduces the vasculogenic mimicry of human glioma cells by regulating periostin-dependent migration". Oncology Reports 35, no. 3 (2016): 1771-1777. https://doi.org/10.3892/or.2016.4548