B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance

  • Authors:
    • Chenglin Huang
    • Lei Zhou
    • Xiaohan Chang
    • Xiaoao Pang
    • Huijie Zhang
    • Shulan Zhang
  • View Affiliations

  • Published online on: February 2, 2016     https://doi.org/10.3892/or.2016.4607
  • Pages: 2183-2190
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Abstract

The aim of this study was to determine the expression of B7-H3, B7-H4, Foxp3 and IL-2 in cervical cancer tissues, and evaluate the corresponding clinical significance. The expression of B7-H3, B7-H4, Foxp3 and IL-2 in 108 cervical cancer specimens was detected using immunohistochemistry, and their relationship with clinicopathologic parameters was determined. B7-H3, B7-H4 and Foxp3 had high levels of expression in cervical cancer cells (72.22, 80.56, and 91.56%, respectively). B7-H3 levels were only significantly associated with tumor size (P=0.013), while B7-H4, Foxp3 and IL-2 levels were significantly associated with International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.023, 0.014 and 0.036, respectively) and tumor size (P=0.045, 0.010 and 0.021, respectively). Their expression levels were not correlated with age, histologic type, differentiation and lymph node metastasis (all P>0.05). Cox regression multivariate analysis confirmed that B7-H3 or B7-H4 overexpression was an independent prognostic factor. In addition, there were significant positive relationships between the expression of B7-H3 and B7-H4 with Foxp3 (P<0.001). In contrast, the expression of B7-H3 and B7-H4 was negatively correlated with IL-2 (P<0.05). B7-H3, B7-H4 and Foxp3 may be useful biomarkers in patients with cervical cancer for predicting treatment.
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April-2016
Volume 35 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Huang C, Zhou L, Chang X, Pang X, Zhang H and Zhang S: B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance. Oncol Rep 35: 2183-2190, 2016.
APA
Huang, C., Zhou, L., Chang, X., Pang, X., Zhang, H., & Zhang, S. (2016). B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance. Oncology Reports, 35, 2183-2190. https://doi.org/10.3892/or.2016.4607
MLA
Huang, C., Zhou, L., Chang, X., Pang, X., Zhang, H., Zhang, S."B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance". Oncology Reports 35.4 (2016): 2183-2190.
Chicago
Huang, C., Zhou, L., Chang, X., Pang, X., Zhang, H., Zhang, S."B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance". Oncology Reports 35, no. 4 (2016): 2183-2190. https://doi.org/10.3892/or.2016.4607