miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion

  • Authors:
    • Jun Huang
    • Bin Wang
    • Ke Hui
    • Jin Zeng
    • Jinhai Fan
    • Xinyang Wang
    • Jer-Tsong Hsieh
    • Dalin He
    • Kaijie Wu
  • View Affiliations

  • Published online on: July 15, 2016     https://doi.org/10.3892/or.2016.4940
  • Pages: 1693-1701
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Muscle-invasive or metastatic bladder cancer (BCa) has a very poor prognosis; however, its mechanisms remain largely unknown. Previous studies have discovered multiple microRNAs (miRs) that are involved in BCa progression and regarded as potential biomarkers or therapeutic targets. In this study, we demonstrated that miR-92b could uniquely promote cell migration and invasion of BCa cells, but had no effect on cell proliferation. Mechanistically, our data provided evidence to verify that miR-92b was able to directly target DAB2IP, a well-known tumor suppressor, and inhibit epithelial‑mesenchymal transition of BCa cells. Moreover, the increased expression levels of miR-92b were negatively correlated with DAB2IP, and predicted poor prognosis of patients with BCa. Overall, this study reveals a new promising biomarker and its mechanisms contributing to BCa invasion or metastasis.
View Figures
View References

Related Articles

Journal Cover

September-2016
Volume 36 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang J, Wang B, Hui K, Zeng J, Fan J, Wang X, Hsieh J, He D and Wu K: miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion. Oncol Rep 36: 1693-1701, 2016.
APA
Huang, J., Wang, B., Hui, K., Zeng, J., Fan, J., Wang, X. ... Wu, K. (2016). miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion. Oncology Reports, 36, 1693-1701. https://doi.org/10.3892/or.2016.4940
MLA
Huang, J., Wang, B., Hui, K., Zeng, J., Fan, J., Wang, X., Hsieh, J., He, D., Wu, K."miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion". Oncology Reports 36.3 (2016): 1693-1701.
Chicago
Huang, J., Wang, B., Hui, K., Zeng, J., Fan, J., Wang, X., Hsieh, J., He, D., Wu, K."miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion". Oncology Reports 36, no. 3 (2016): 1693-1701. https://doi.org/10.3892/or.2016.4940