Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia

  • Authors:
    • Jana Šmahelová
    • Iva Kaštánková
    • Kateřina Machová Poláková
    • Hana Klamová
    • Karla Zemanová
    • Ruth Tachezy
    • Eva Hamšíková
    • Michal Šmahel
  • View Affiliations

  • Published online on: November 7, 2016     https://doi.org/10.3892/or.2016.5226
  • Pages: 547-554
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Abstract

As the extent of centrosome abnormalities in chronic myeloid leukemia (CML) correlates with disease stage and karyotype alterations, abnormal expression of genes encoding centrosomal proteins may be an early prognostic marker of disease progression. In the present study, we showed that in comparison with healthy controls, the expression of four centrosomal genes (AURKA, HMMR, PLK1 and ESPL1) in the peripheral blood of CML patients was significantly enhanced at diagnosis and decreased to the basal level in most patients treated with imatinib mesylate for three months. In the remaining patients (17%), this decrease was delayed and was associated with worse overall survival. The detection of antibodies in sera showed that patients with higher overall antibody production had superior outcomes in terms of achieving major molecular response and failure-free survival. These data suggest that the dynamics of the response of centrosomal genes should be considered as a risk factor and immunity against centrosomal proteins may contribute to treatment response.
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January-2017
Volume 37 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Šmahelová J, Kaštánková I, Poláková KM, Klamová H, Zemanová K, Tachezy R, Hamšíková E and Šmahel M: Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia. Oncol Rep 37: 547-554, 2017.
APA
Šmahelová, J., Kaštánková, I., Poláková, K.M., Klamová, H., Zemanová, K., Tachezy, R. ... Šmahel, M. (2017). Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia. Oncology Reports, 37, 547-554. https://doi.org/10.3892/or.2016.5226
MLA
Šmahelová, J., Kaštánková, I., Poláková, K. M., Klamová, H., Zemanová, K., Tachezy, R., Hamšíková, E., Šmahel, M."Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia". Oncology Reports 37.1 (2017): 547-554.
Chicago
Šmahelová, J., Kaštánková, I., Poláková, K. M., Klamová, H., Zemanová, K., Tachezy, R., Hamšíková, E., Šmahel, M."Expression of genes encoding centrosomal proteins and the humoral response against these proteins in chronic myeloid leukemia". Oncology Reports 37, no. 1 (2017): 547-554. https://doi.org/10.3892/or.2016.5226