Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis

  • Authors:
    • Eungyeong Jang
    • So-Young Kim
    • Na-Rae Lee
    • Chae-Min Yi
    • Da-Rong Hong
    • Woo Seok Lee
    • Jong-Ho Kim
    • Kyung-Tae Lee
    • Bum-Joon Kim
    • Jang-Hoon Lee
    • Kyung-Soo Inn
  • View Affiliations

  • Published online on: November 29, 2016     https://doi.org/10.3892/or.2016.5283
  • Pages: 526-532
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Abstract

Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway plays critical roles in the development and progression of hepatocellular carcinoma (HCC). Artemisia capillaris (AC) has been widely used to treat various liver diseases including HCC as a herbal medicine. The effects of AC on IL-6/STAT3 signaling axis in HCC cells and subsequent anticancer activity of AC against HCC were analyzed using HCC cell lines and HBV W4P-LHB-expressing NIH3T3 cell line, which has been shown to gain tumorigenicity by activating IL-6/STAT3 signaling in our previous study. AC extract significantly suppressed the growth and colony formation of HCC cells. In addition, it inhibited the activation of STAT3 by IL-6 and subsequent synthesis of downstream molecules in HCC and W4P-NIH3T3 cells. Consequently, migration of cells was significantly suppressed by the AC extract. Collectively, the findings suggest that AC extract is capable of conferring various antitumor effects against HCC through the modulation of the IL-6/STAT3 pathway. The results provide a basis for the therapeutic use of AC in the treatment of HCC. Identification of the compound responsible for the effect may lead to the development of a novel anticancer agent against HCC.
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January-2017
Volume 37 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jang E, Kim S, Lee N, Yi C, Hong D, Lee WS, Kim J, Lee K, Kim B, Lee J, Lee J, et al: Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis. Oncol Rep 37: 526-532, 2017.
APA
Jang, E., Kim, S., Lee, N., Yi, C., Hong, D., Lee, W.S. ... Inn, K. (2017). Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis. Oncology Reports, 37, 526-532. https://doi.org/10.3892/or.2016.5283
MLA
Jang, E., Kim, S., Lee, N., Yi, C., Hong, D., Lee, W. S., Kim, J., Lee, K., Kim, B., Lee, J., Inn, K."Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis". Oncology Reports 37.1 (2017): 526-532.
Chicago
Jang, E., Kim, S., Lee, N., Yi, C., Hong, D., Lee, W. S., Kim, J., Lee, K., Kim, B., Lee, J., Inn, K."Evaluation of antitumor activity of Artemisia capillaris extract against hepatocellular carcinoma through the inhibition of IL-6/STAT3 signaling axis". Oncology Reports 37, no. 1 (2017): 526-532. https://doi.org/10.3892/or.2016.5283