1
|
Smith A, Teknos TN and Pan Q: Epithelial
to mesenchymal transition in head and neck squamous cell carcinoma.
Oral Oncol. 49:287–292. 2013. View Article : Google Scholar : PubMed/NCBI
|
2
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial- mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
3
|
Weber CE, Li NY, Wai PY and Kuo PC:
Epithelial-mesenchymal transition, TGF-β, and osteopontin in wound
healing and tissue remodeling after injury. J Burn Care Res.
33:311–318. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
He J, Xu Y, Koya D and Kanasaki K: Role of
the endothelial-to-mesenchymal transition in renal fibrosis of
chronic kidney disease. Clin Exp Nephrol. 17:488–497. 2013.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Fabregat I, Malfettone A and Soukupova J:
New insights into the crossroads between EMT and stemness in the
context of cancer. J Clin Med. 5:372016. View Article : Google Scholar
|
6
|
Moustakas A and Heldin P: TGFβ and
matrix-regulated epithelial to mesenchymal transition. Biochim
Biophys Acta. 1840:2621–2634. 2014. View Article : Google Scholar : PubMed/NCBI
|
7
|
Batlle E, Sancho E, Francí C, Domínguez D,
Monfar M, Baulida J and De Herreros A García: The transcription
factor snail is a repressor of E-cadherin gene expression in
epithelial tumour cells. Nat Cell Biol. 2:84–89. 2000. View Article : Google Scholar : PubMed/NCBI
|
8
|
Medici D, Hay ED and Olsen BR: Snail and
Slug promote epithelial-mesenchymal transition through
β-catenin-T-cell factor-4-dependent expression of transforming
growth factor-β3. Mol Biol Cell. 19:4875–4887. 2008. View Article : Google Scholar : PubMed/NCBI
|
9
|
Zeisberg M and Neilson EG: Biomarkers for
epithelial-mesenchymal transitions. J Clin Invest. 119:1429–1437.
2009. View
Article : Google Scholar : PubMed/NCBI
|
10
|
Peinado H, Olmeda D and Cano A: Snail, Zeb
and bHLH factors in tumour progression: An alliance against the
epithelial phenotype? Nat Rev Cancer. 7:415–428. 2007. View Article : Google Scholar : PubMed/NCBI
|
11
|
Lamouille S, Xu J and Derynck R: Molecular
mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell
Biol. 15:178–196. 2014. View
Article : Google Scholar : PubMed/NCBI
|
12
|
Wakefield LM and Hill CS: Beyond TGFβ:
Roles of other TGFβ superfamily members in cancer. Nat Rev Cancer.
13:328–341. 2013. View
Article : Google Scholar : PubMed/NCBI
|
13
|
Simic P and Vukicevic S: Bone
morphogenetic proteins in development and homeostasis of kidney.
Cytokine Growth Factor Rev. 16:299–308. 2005. View Article : Google Scholar : PubMed/NCBI
|
14
|
Bragdon B, Moseychuk O, Saldanha S, King
D, Julian J and Nohe A: Bone morphogenetic proteins: A critical
review. Cell Signal. 23:609–620. 2011. View Article : Google Scholar : PubMed/NCBI
|
15
|
Wu M, Chen G and Li YP: TGF-β and BMP
signaling in osteoblast, skeletal development and bone formation,
homeostasis and disease. Bone Res. 4:160092016. View Article : Google Scholar : PubMed/NCBI
|
16
|
Kopf J, Paarmann P, Hiepen C, Horbelt D
and Knaus P: BMP growth factor signaling in a biomechanical
context. Biofactors. 40:171–187. 2014. View Article : Google Scholar : PubMed/NCBI
|
17
|
Chen G, Deng C and Li YP: TGF-β and BMP
signaling in osteoblast differentiation and bone formation. Int J
Biol Sci. 8:272–288. 2012. View Article : Google Scholar : PubMed/NCBI
|
18
|
McCormack N and O'Dea S: Regulation of
epithelial to mesenchymal transition by bone morphogenetic
proteins. Cell Signal. 25:2856–2862. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Kang MH, Kim JS, Seo JE, Oh SC and Yoo YA:
BMP2 accelerates the motility and invasiveness of gastric cancer
cells via activation of the phosphatidylinositol 3-kinase
(PI3K)/Akt pathway. Exp Cell Res. 316:24–37. 2010. View Article : Google Scholar : PubMed/NCBI
|
20
|
Yang YL, Ju HZ, Liu SF, Lee TC, Shih YW,
Chuang LY, Guh JY, Yang YY, Liao TN, Hung TJ, et al: BMP-2
suppresses renal interstitial fibrosis by regulating
epithelial-mesenchymal transition. J Cell Biochem. 112:2558–2565.
2011. View Article : Google Scholar : PubMed/NCBI
|
21
|
Graves CA, Abboodi FF, Tomar S, Wells J
and Pirisi L: The translational significance of
epithelial-mesenchymal transition in head and neck cancer. Clin
Transl Med. 3:602014. View Article : Google Scholar : PubMed/NCBI
|
22
|
Lambert R, Sauvaget C, de Camargo Cancela
M and Sankaranarayanan R: Epidemiology of cancer from the oral
cavity and oropharynx. Eur J Gastroenterol Hepatol. 23:633–641.
2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Kokorina NA, Lewis JS Jr, Zakharkin SO,
Krebsbach PH and Nussenbaum B: rhBMP-2 has adverse effects on human
oral carcinoma cell lines in vivo. Laryngoscope. 122:95–102. 2012.
View Article : Google Scholar : PubMed/NCBI
|
24
|
Kokorina NA, Zakharkin SO, Krebsbach PH
and Nussenbaum B: Treatment effects of rhBMP-2 on invasiveness of
oral carcinoma cell lines. Laryngoscope. 121:1876–1880.
2011.PubMed/NCBI
|
25
|
Sand JP, Kokorina NA, Zakharkin SO, Lewis
JS Jr and Nussenbaum B: BMP-2 expression correlates with local
failure in head and neck squamous cell carcinoma. Otolaryngol Head
Neck Surg. 150:245–250. 2014. View Article : Google Scholar : PubMed/NCBI
|
26
|
Kejner AE, Burch MB, Sweeny L and
Rosenthal EL: Bone morphogenetic protein 6 expression in oral
cavity squamous cell cancer is associated with bone invasion.
Laryngoscope. 123:3061–3065. 2013. View Article : Google Scholar : PubMed/NCBI
|
27
|
Quan J, Johnson NW, Zhou G, Parsons PG,
Boyle GM and Gao J: Potential molecular targets for inhibiting bone
invasion by oral squamous cell carcinoma: A review of mechanisms.
Cancer Metastasis Rev. 31:209–219. 2012. View Article : Google Scholar : PubMed/NCBI
|
28
|
Saito D, Kyakumoto S, Chosa N, Ibi M,
Takahashi N, Okubo N, Sawada S, Ishisaki A and Kamo M: Transforming
growth factor-β1 induces epithelial-mesenchymal transition and
integrin α3β1-mediated cell migration of HSC-4 human squamous cell
carcinoma cells through Slug. J Biochem. 153:303–315. 2013.
View Article : Google Scholar : PubMed/NCBI
|
29
|
Hino M, Kamo M, Saito D, Kyakumoto S,
Shibata T, Mizuki H and Ishisaki A: Transforming growth factor-β1
induces invasion ability of HSC-4 human oral squamous cell
carcinoma cells through the Slug/Wnt-5b/MMP-10 signalling axis. J
Biochem. 159:631–640. 2016. View Article : Google Scholar : PubMed/NCBI
|
30
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2−ΔΔCT Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI
|
31
|
Lasorella A, Benezra R and Iavarone A: The
ID proteins: Master regulators of cancer stem cells and tumour
aggressiveness. Nat Rev Cancer. 14:77–91. 2014. View Article : Google Scholar : PubMed/NCBI
|
32
|
Shi W, Chen H, Sun J, Chen C, Zhao J, Wang
YL, Anderson KD and Warburton D: Overexpression of Smurf1
negatively regulates mouse embryonic lung branching morphogenesis
by specifically reducing Smad1 and Smad5 proteins. Am J Physiol
Lung Cell Mol Physiol. 286:L293–L300. 2004. View Article : Google Scholar : PubMed/NCBI
|
33
|
Murakami G, Watabe T, Takaoka K, Miyazono
K and Imamura T: Cooperative inhibition of bone morphogenetic
protein signaling by Smurf1 and inhibitory Smads. Mol Biol Cell.
14:2809–2817. 2003. View Article : Google Scholar : PubMed/NCBI
|
34
|
Kim BG, Lee JH, Yasuda J, Ryoo HM and Cho
JY: Phospho-Smad1 modulation by nedd4 e3 ligase in BMP/TGF-β
signaling. J Bone Miner Res. 26:1411–1424. 2011. View Article : Google Scholar : PubMed/NCBI
|
35
|
Lin X, Liang M and Feng XH: Smurf2 is a
ubiquitin E3 ligase mediating proteasome-dependent degradation of
Smad2 in transforming growth factor-β signaling. J Biol Chem.
275:36818–36822. 2000. View Article : Google Scholar : PubMed/NCBI
|
36
|
Gao S, Alarcón C, Sapkota G, Rahman S,
Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P and
Massagué J: Ubiquitin ligase Nedd4L targets activated Smad2/3 to
limit TGF-β signaling. Mol Cell. 36:457–468. 2009. View Article : Google Scholar : PubMed/NCBI
|
37
|
Ogata T, Wozney JM, Benezra R and Noda M:
Bone morphogenetic protein 2 transiently enhances expression of a
gene, Id (inhibitor of differentiation), encoding a
helix-loop-helix molecule in osteoblast-like cells. Proc Natl Acad
Sci USA. 90:9219–9222. 1993. View Article : Google Scholar : PubMed/NCBI
|
38
|
Langenfeld EM, Kong Y and Langenfeld J:
Bone morphogenetic protein 2 stimulation of tumor growth involves
the activation of Smad-1/5. Oncogene. 25:685–692. 2006. View Article : Google Scholar : PubMed/NCBI
|
39
|
Stankic M, Pavlovic S, Chin Y, Brogi E,
Padua D, Norton L, Massagué J and Benezra R: TGF-β-Id1 signaling
opposes Twist1 and promotes metastatic colonization via a
mesenchymal-to-epithelial transition. Cell Reports. 5:1228–1242.
2013. View Article : Google Scholar : PubMed/NCBI
|
40
|
Del Pozo Martin Y, Park D, Ramachandran A,
Ombrato L, Calvo F, Chakravarty P, Spencer-Dene B, Derzsi S, Hill
CS, Sahai E, et al: Mesenchymal cancer cell-stroma crosstalk
promotes niche activation, epithelial reversion, and metastatic
colonization. Cell Reports. 13:2456–2469. 2015. View Article : Google Scholar : PubMed/NCBI
|
41
|
Yao H, Li H, Yang S, Li M, Zhao C, Zhang
J, Xu G and Wang F: Inhibitory effect of bone morphogenetic protein
4 in retinal pigment epithelial-mesenchymal transition. Sci Rep.
6:321822016. View Article : Google Scholar : PubMed/NCBI
|