Torilis japonica extract fraction compound, EGFR-targeted inhibition of cancer abnormal metastasis in A549 lung cancer cells

  • Authors:
    • Guen Tae Kim
    • Sang-Yong Kim
    • Young Min Kim
  • View Affiliations

  • Published online on: June 30, 2017     https://doi.org/10.3892/or.2017.5771
  • Pages: 1206-1212
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Abstract

The number of patients who die from lung cancer is steadily increasing. According to the 2012 statistics, lung cancer accounts for the highest percentage of death from cancer in both sexes. Many research studies found that lung cancer can be caused not only by smoking but by outdoor pollution, and it leads to over-activation of various surface proteins in cancer cells. The over-activity of epidermal growth factor receptor (EGFR) is implicated as a crucial factor in inducing abnormal metastasis of lung cancer cells. In this study, we investigated the inhibitory effect of Torilis japonica extract (TJE) major fraction compound in A549 lung cancer cells by inhibiting EGFR activity. We confirmed that inhibitory effect of TJE on the abnormal metastasis using invasion assay and 3D cell culture method, as well as the inhibition of EGFR signaling pathway, co-binding with Stat3 and dimer formation for translocation to the nucleus. We confirmed the EGFR targets inhibition of TJE when compared with EGFR knockdown group using siRNA transfection. The CAM assay confirmed once again the efficacy of the TJE. We suggest that TJE is a new potential reagent for EGFR-targeted therapy and anti-abnormal metastasis in A549 lung cancer cells.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Kim GT, Kim S and Kim YM: Torilis japonica extract fraction compound, EGFR-targeted inhibition of cancer abnormal metastasis in A549 lung cancer cells. Oncol Rep 38: 1206-1212, 2017.
APA
Kim, G.T., Kim, S., & Kim, Y.M. (2017). Torilis japonica extract fraction compound, EGFR-targeted inhibition of cancer abnormal metastasis in A549 lung cancer cells. Oncology Reports, 38, 1206-1212. https://doi.org/10.3892/or.2017.5771
MLA
Kim, G. T., Kim, S., Kim, Y. M."Torilis japonica extract fraction compound, EGFR-targeted inhibition of cancer abnormal metastasis in A549 lung cancer cells". Oncology Reports 38.2 (2017): 1206-1212.
Chicago
Kim, G. T., Kim, S., Kim, Y. M."Torilis japonica extract fraction compound, EGFR-targeted inhibition of cancer abnormal metastasis in A549 lung cancer cells". Oncology Reports 38, no. 2 (2017): 1206-1212. https://doi.org/10.3892/or.2017.5771