Immunocytochemical stem cell markers can predict clinical stage of breast cancer

  • Authors:
    • Pedro J. Gutiérrez Diez
    • Yanrong Su
    • Jose Russo
  • View Affiliations

  • Published online on: July 14, 2017     https://doi.org/10.3892/or.2017.5820
  • Pages: 1507-1516
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We present a computational-statistical algorithm that, from data on the staining degree of immunocytochemical markers: i) evaluates the ability of the considered immuno­panel in predicting the breast cancer stage; ii) makes the accurate identification of breast cancer stage possible; iii) provides the best stage prognosis compatible with the considered sample; and iv) does so through the use of the minimum number of markers minimizing time and resource costs. After running the algorithm on two data sets [triple-negative breast cancer, (TNBC), and estrogen receptor-negative breast cancer, (ERNBC)], we conclude that EpCAM and β1 integrin are enough to accurately predict TNBC stage, being ALDH1, CD24, CD61, and CK5 the necessary markers to exactly predict ERNBC stage.
View References

Related Articles

Journal Cover

September-2017
Volume 38 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gutiérrez Diez PJ, Su Y and Russo J: Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncol Rep 38: 1507-1516, 2017
APA
Gutiérrez Diez, P.J., Su, Y., & Russo, J. (2017). Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Oncology Reports, 38, 1507-1516. https://doi.org/10.3892/or.2017.5820
MLA
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38.3 (2017): 1507-1516.
Chicago
Gutiérrez Diez, P. J., Su, Y., Russo, J."Immunocytochemical stem cell markers can predict clinical stage of breast cancer". Oncology Reports 38, no. 3 (2017): 1507-1516. https://doi.org/10.3892/or.2017.5820