1
|
Parkin DM, Bray F, Ferlay J and Pisani P:
Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Jemal A, Siegel R, Xu J and Ward E: Cancer
statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar : PubMed/NCBI
|
3
|
Nakielny S and Dreyfuss G: Transport of
proteins and RNAs in and out of the nucleus. Cell. 99:677–690.
1999. View Article : Google Scholar : PubMed/NCBI
|
4
|
Chook YM and Blobel G: Karyopherins and
nuclear import. Curr Opin Struct Biol. 11:703–715. 2001. View Article : Google Scholar : PubMed/NCBI
|
5
|
Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling
P, Bartholomeusz G, Wang SC and Hung MC: Endosomal transport of
ErbB-2: Mechanism for nuclear entry of the cell surface receptor.
Mol Cell Biol. 25:11005–11018. 2005. View Article : Google Scholar : PubMed/NCBI
|
6
|
Lo HW, Ali-Seyed M, Wu Y, Bartholomeusz G,
Hsu SC and Hung MC: Nuclear-cytoplasmic transport of EGFR involves
receptor endocytosis, importin beta1 and CRM1. J Cell Biochem.
98:1570–1583. 2006. View Article : Google Scholar : PubMed/NCBI
|
7
|
Zhen Y, Sørensen V, Skjerpen CS, Haugsten
EM, Jin Y, Wälchli S, Olsnes S and Wiedlocha A: Nuclear import of
exogenous FGF1 requires the ER-protein LRRC59 and the importins
Kpnα1 and Kpnβ1. Traffic. 13:650–664. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Mosammaparast N and Pemberton LF:
Karyopherins: From nuclear-transport mediators to nuclear-function
regulators. Trends Cell Biol. 14:547–556. 2004. View Article : Google Scholar : PubMed/NCBI
|
9
|
Altan B, Yokobori T, Mochiki E, Ohno T,
Ogata K, Ogawa A, Yanai M, Kobayashi T, Luvsandagva B, Asao T, et
al: Nuclear karyopherin-α2 expression in primary lesions and
metastatic lymph nodes was associated with poor prognosis and
progression in gastric cancer. Carcinogenesis. 34:2314–2321. 2013.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Grupp K, Habermann M, Sirma H, Simon R,
Steurer S, Hube-Magg C, Prien K, Burkhardt L, Jedrzejewska K,
Salomon G, et al: High nuclear karyopherin α 2 expression is a
strong and independent predictor of biochemical recurrence in
prostate cancer patients treated by radical prostatectomy. Mod
Pathol. 27:96–106. 2014. View Article : Google Scholar : PubMed/NCBI
|
11
|
Huang L, Wang HY, Li JD, Wang JH, Zhou Y,
Luo RZ, Yun JP, Zhang Y, Jia WH and Zheng M: KPNA2 promotes cell
proliferation and tumorigenicity in epithelial ovarian carcinoma
through upregulation of c-Myc and downregulation of FOXO3a. Cell
Death Dis. 4:e7452013. View Article : Google Scholar : PubMed/NCBI
|
12
|
Pavlou MP, Dimitromanolakis A,
Martinez-Morillo E, Smid M, Foekens JA and Diamandis EP:
Integrating meta-analysis of microarray data and targeted
proteomics for biomarker identification: Application in breast
cancer. J Proteome Res. 13:2897–2909. 2014. View Article : Google Scholar : PubMed/NCBI
|
13
|
Ikenberg K, Valtcheva N, Brandt S, Zhong
Q, Wong CE, Noske A, Rechsteiner M, Rueschoff JH, Caduff R, Dellas
A, et al: KPNA2 is overexpressed in human and mouse endometrial
cancers and promotes cellular proliferation. J Pathol. 234:239–252.
2014.PubMed/NCBI
|
14
|
Hu ZY, Yuan SX, Yang Y, Zhou WP and Jiang
H: Pleomorphic adenoma gene 1 mediates the role of karyopherin
alpha 2 and has prognostic significance in hepatocellular
carcinoma. J Exp Clin Cancer Res. 33:612014. View Article : Google Scholar : PubMed/NCBI
|
15
|
Ma S and Zhao X: KPNA2 is a promising
biomarker candidate for esophageal squamous cell carcinoma and
correlates with cell proliferation. Oncol Rep. 32:1631–1637. 2014.
View Article : Google Scholar : PubMed/NCBI
|
16
|
van der Watt PJ, Maske CP, Hendricks DT,
Parker MI, Denny L, Govender D, Birrer MJ and Leaner VD: The
karyopherin proteins, Crm1 and karyopherin beta1, are overexpressed
in cervical cancer and are critical for cancer cell survival and
proliferation. Int J Cancer. 124:1829–1840. 2009. View Article : Google Scholar : PubMed/NCBI
|
17
|
Zhang P, Garnett J, Creighton CJ, Al
Sannaa GA, Igram DR, Lazar A, Liu X, Liu C and Pollock RE:
EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve
sheath tumour cell survival and tumourigenesis. J Pathol.
232:308–318. 2014. View Article : Google Scholar : PubMed/NCBI
|
18
|
Martens-de Kemp SR, Nagel R, Stigter-van
Walsum M, van der Meulen IH, van Beusechem VW, Braakhuis BJ and
Brakenhoff RH: Functional genetic screens identify genes essential
for tumor cell survival in head and neck and lung cancer. Clin
Cancer Res. 19:1994–2003. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
van der Watt PJ, Stowell CL and Leaner VD:
The nuclear import receptor Kpnβ1 and its potential as an
anticancer therapeutic target. Crit Rev Eukaryot Gene Expr.
23:1–10. 2013. View Article : Google Scholar : PubMed/NCBI
|
20
|
Nordgard SH, Johansen FE, Alnaes GI,
Bucher E, Syvänen AC, Naume B, Børresen-Dale AL and Kristensen VN:
Genome-wide analysis identifies 16q deletion associated with
survival, molecular subtypes, mRNA expression, and germline
haplotypes in breast cancer patients. Genes Chromosomes Cancer.
47:680–696. 2008. View Article : Google Scholar : PubMed/NCBI
|
21
|
Ross JS and Fletcher JA: The HER-2/neu
oncogene in breast cancer: Prognostic factor, predictive factor,
and target for therapy. Oncologist. 3:237–252. 1998.PubMed/NCBI
|
22
|
Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ,
Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, et al: Nuclear ErbB2
enhances translation and cell growth by activating transcription of
ribosomal RNA genes. Cancer Res. 71:4269–4279. 2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Gucalp A, Gupta GP, Pilewskie ML, Sutton
EJ and Norton L: Advances in managing breast cancer: A clinical
update. F1000Prime Rep. 6:662014. View
Article : Google Scholar : PubMed/NCBI
|
24
|
Lu T, Bao Z, Wang Y, Yang L, Lu B, Yan K,
Wang S, Wei H, Zhang Z and Cui G: Karyopherin β1 regulates
proliferation of human glioma cells via Wnt/β-catenin pathway.
Biochem Biophys Res Commun. 478:1189–1197. 2016. View Article : Google Scholar : PubMed/NCBI
|
25
|
Wang S, Zhao Y, Xia N, Zhang W, Tang Z,
Wang C, Zhu X and Cui S: KPNβ1 promotes palmitate-induced insulin
resistance via NF-κB signaling in hepatocytes. J Physiol Biochem.
71:763–772. 2015. View Article : Google Scholar : PubMed/NCBI
|
26
|
Lee Y, Jang AR, Francey LJ, Sehgal A and
Hogenesch JB: KPNB1 mediates PER/CRY nuclear translocation and
circadian clock function. eLife. 4:e086472015. View Article : Google Scholar :
|
27
|
Bennett SM, Zhao L, Bosard C and Imperiale
MJ: Role of a nuclear localization signal on the minor capsid
proteins VP2 and VP3 in BKPyV nuclear entry. Virology. 474:110–116.
2015. View Article : Google Scholar : PubMed/NCBI
|
28
|
Sun C, Yu Z, Wang Y and Tao T: The
importin protein karyopherin-β1 regulates the mice fibroblast-like
synoviocytes inflammation via facilitating nucleus transportation
of STAT3 transcription factor. Biochem Biophys Res Commun.
471:553–559. 2016. View Article : Google Scholar : PubMed/NCBI
|
29
|
Kuusisto HV and Jans DA: Hyper-dependence
of breast cancer cell types on the nuclear transporter importin β1.
Biochim Biophys Acta. 1853:1870–1878. 2015. View Article : Google Scholar : PubMed/NCBI
|
30
|
Angus L, van der Watt PJ and Leaner VD:
Inhibition of the nuclear transporter, Kpnβ1, results in prolonged
mitotic arrest and activation of the intrinsic apoptotic pathway in
cervical cancer cells. Carcinogenesis. 35:1121–1131. 2014.
View Article : Google Scholar : PubMed/NCBI
|
31
|
Kojima Y, Nakayama M, Nishina T, Nakano H,
Koyanagi M, Takeda K, Okumura K and Yagita H: Importin β1
protein-mediated nuclear localization of death receptor 5 (DR5)
limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing
ligand (TRAIL)-induced cell death of human tumor cells. J Biol
Chem. 286:43383–43393. 2011. View Article : Google Scholar : PubMed/NCBI
|
32
|
Kim YH, Ha S, Kim J and Ham SW:
Identification of KPNB1 as a cellular target of aminothiazole
derivatives with anticancer activity. ChemMedChem. 11:1406–1409.
2016. View Article : Google Scholar : PubMed/NCBI
|
33
|
van der Watt PJ, Ngarande E and Leaner VD:
Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer
derives from deregulated E2F activity. PLoS One. 6:e277232011.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Zhang P, Yang X, Ma X, Ingram DR, Lazar
AJ, Torres KE and Pollock RE: Antitumor effects of pharmacological
EZH2 inhibition on malignant peripheral nerve sheath tumor through
the miR-30a and KPNB1 pathway. Mol Cancer. 14:552015. View Article : Google Scholar : PubMed/NCBI
|
35
|
Cordo Russo RI, Béguelin W, Díaz Flaqué
MC, Proietti CJ, Venturutti L, Galigniana N, Tkach M, Guzmán P, Roa
JC, O'Brien NA, et al: Targeting ErbB-2 nuclear localization and
function inhibits breast cancer growth and overcomes trastuzumab
resistance. Oncogene. 34:3413–3428. 2015. View Article : Google Scholar : PubMed/NCBI
|