Open Access

Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells

  • Authors:
    • Jia Ouyang
    • Hui Xu
    • Ming Li
    • Xingliang Dai
    • Fengqing Fu
    • Xueguang Zhang
    • Qing Lan
  • View Affiliations

  • Published online on: December 28, 2017     https://doi.org/10.3892/or.2017.6175
  • Pages: 1052-1062
  • Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 overexpression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.
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March-2018
Volume 39 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ouyang J, Xu H, Li M, Dai X, Fu F, Zhang X and Lan Q: Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncol Rep 39: 1052-1062, 2018.
APA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., & Lan, Q. (2018). Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Oncology Reports, 39, 1052-1062. https://doi.org/10.3892/or.2017.6175
MLA
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39.3 (2018): 1052-1062.
Chicago
Ouyang, J., Xu, H., Li, M., Dai, X., Fu, F., Zhang, X., Lan, Q."Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells". Oncology Reports 39, no. 3 (2018): 1052-1062. https://doi.org/10.3892/or.2017.6175