Aspirin and metformin exhibit antitumor activity in murine breast cancer

  • Authors:
    • Maoyuan Zhao
    • Yuyi Wang
    • Chi Du
    • Yanyang Liu
    • Nan Zhang
    • Feng Luo
  • View Affiliations

  • Published online on: January 4, 2018     https://doi.org/10.3892/or.2018.6190
  • Pages: 1414-1422
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Abstract

Studies have shown that aspirin and metformin play important roles in chemoprevention and repression of breast cancers, even though the exact mechanism remains unclear. Aspirin is capable of stimulating apoptosis through prostaglandin-dependent or prostaglandin-independent pathways. Metformin inhibits cell growth by enhancing the tumor suppressive function of transforming growth factor (TGF-β). In the present study, we report a new link between aspirin, metformin, TGF-β1 and murine breast cancer inhibition. Specifically, we showed that aspirin and metformin enhanced 4T1 cell apoptosis by inducing secretion of TGF-β1, whereas estradiol weakened the effect.
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March-2018
Volume 39 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao M, Wang Y, Du C, Liu Y, Zhang N and Luo F: Aspirin and metformin exhibit antitumor activity in murine breast cancer. Oncol Rep 39: 1414-1422, 2018.
APA
Zhao, M., Wang, Y., Du, C., Liu, Y., Zhang, N., & Luo, F. (2018). Aspirin and metformin exhibit antitumor activity in murine breast cancer. Oncology Reports, 39, 1414-1422. https://doi.org/10.3892/or.2018.6190
MLA
Zhao, M., Wang, Y., Du, C., Liu, Y., Zhang, N., Luo, F."Aspirin and metformin exhibit antitumor activity in murine breast cancer". Oncology Reports 39.3 (2018): 1414-1422.
Chicago
Zhao, M., Wang, Y., Du, C., Liu, Y., Zhang, N., Luo, F."Aspirin and metformin exhibit antitumor activity in murine breast cancer". Oncology Reports 39, no. 3 (2018): 1414-1422. https://doi.org/10.3892/or.2018.6190