Downregulation of the long non-coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer

Li,Yue; Zhao,Lin; Zhang,Yining; Guan,Lin; Zhang,Huijing; Zhou,Huan; Gao,Tong; Miao,Peng; Sun,Mingjun

doi:10.3892/or.2018.6260

Downregulation of the long non-coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer

Authors:
- Yue Li
- Lin Zhao
- Yining Zhang
- Lin Guan
- Huijing Zhang
- Huan Zhou
- Tong Gao
- Peng Miao
- Mingjun Sun
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Affiliations: Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pharmacology, School of Pharmaceutical Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of Endoscopy, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Anal and Intestinal Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: February 12, 2018 https://doi.org/10.3892/or.2018.6260
Pages: 1619-1630
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long non-coding RNAs (lncRNAs) have emerged as major players in many biological and pathological processes; however, investigation into the function of lncRNAs in the development and progression of cancer is in its infancy. Therefore, clarification of the mechanism by which cancer‑related lncRNAs function is of critical importance in research on tumorigenesis. It has been demonstrated that the lncRNA XLOC_010588 is expressed at a low level in cervical cancer, and that this has significant impact on the proliferation of cervical cancer cells. However, the expression pattern and functional roles of XLOC_010588 in colorectal cancer (CRC) remain unclear. In the present study, it was demonstrated that the expression of XLOC_010588 was significantly higher in CRC tissues when compared with that in adjacent normal tissues, and that XLOC_010588 was closely associated with metastasis and poor prognosis, thus indicating that XLOC_010588 may function as an oncogene. Additionally, downregulation of XLOC_010588 expression markedly inhibited the invasion and migration of CRC cells. Furthermore, it was demonstrated that XLOC_010588 may regulate the progression of CRC via the epithelial-mesenchymal transition (EMT) pathway. Notably, downregulation of XLOC_010588 inhibited the invasion and migration of CRC cells by regulating genes associated with EMT. Our findings revealed that XLOC_010588 may be considered as a novel potential diagnostic biomarker in CRC.

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