miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

  • Authors:
    • Wei Xiong
    • Jianhua Ran
    • Rong Jiang
    • Pei Guo
    • Xueping Shi
    • Haixing Li
    • Xiaoting Lv
    • Jing Li
    • Dilong Chen
  • View Affiliations

  • Published online on: February 20, 2018     https://doi.org/10.3892/or.2018.6274
  • Pages: 1939-1947
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Abstract

Glioma is the most aggressive and malignant type of primary intracranial tumor. In recent decades, despite the rapid development of modern surgery and therapeutic strategies available for brain tumors, the prognosis of glioma remains poor and the median survival time is <15 months. In this study, we found that the levels of miRNA-320a were significantly decreased in patients with glioma, and that elevated miRNA-320a expression was associated with a better prognosis. In addition, aquaporin 4 (AQP4) was identified as a direct target of miRNA-320a. Overexpression of miRNA-320a led to the inhibition of cell invasion and migration via targeting of AQP4. Therefore, our results suggested that miRNA-320a could suppress the aggressive capacity of tumors by targeting AQP4, and that miRNA-320a could serve as a new effective therapeutic target for glioma surgical and therapeutic strategies.
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April-2018
Volume 39 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xiong W, Ran J, Jiang R, Guo P, Shi X, Li H, Lv X, Li J and Chen D: miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4. Oncol Rep 39: 1939-1947, 2018.
APA
Xiong, W., Ran, J., Jiang, R., Guo, P., Shi, X., Li, H. ... Chen, D. (2018). miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4. Oncology Reports, 39, 1939-1947. https://doi.org/10.3892/or.2018.6274
MLA
Xiong, W., Ran, J., Jiang, R., Guo, P., Shi, X., Li, H., Lv, X., Li, J., Chen, D."miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4". Oncology Reports 39.4 (2018): 1939-1947.
Chicago
Xiong, W., Ran, J., Jiang, R., Guo, P., Shi, X., Li, H., Lv, X., Li, J., Chen, D."miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4". Oncology Reports 39, no. 4 (2018): 1939-1947. https://doi.org/10.3892/or.2018.6274