Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma

Morikawa,Asuka; Hayashi,Tomoatsu; Kobayashi,Mana; Kato,Yuki; Shirahige,Katsuhiko; Itoh,Takehiko; Urashima,Mitsuyoshi; Okamoto,Aikou; Akiyama,Tetsu

doi:10.3892/or.2018.6419

Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma

Authors:
- Asuka Morikawa
- Tomoatsu Hayashi
- Mana Kobayashi
- Yuki Kato
- Katsuhiko Shirahige
- Takehiko Itoh
- Mitsuyoshi Urashima
- Aikou Okamoto
- Tetsu Akiyama
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Affiliations: Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113‑0032, Japan, Laboratory of Genome Structure and Function, Research Center for Epigenetic Disease, Institute for Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113‑0032, Japan, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo 152‑8550, Japan, Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo 105‑8461, Japan, Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo 105‑8461, Japan
Published online on: May 8, 2018 https://doi.org/10.3892/or.2018.6419
Pages: 309-318

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Abstract

Ovarian clear cell carcinoma (OCCC) is a chemotherapy‑resistant epithelial ovarian cancer with poor prognosis. To identify genomic alterations involved in the development of OCCC, we analyzed somatic copy number alterations in OCCC using comparative genomic hybridization (CGH). Here we showed that the chromosomal regions 8p11.21, 8p11.22, 12p13.31 and 20q13.2 were amplified in OCCC. We also demonstrated that small segments in the chromosomal regions 3q26.1, 4q13.2 and 22q11.23 were deleted. Kaplan‑Meier survival analyses revealed that patients with amplification within 8p11.21 or a deletion within 3q26.1 had a shorter progression‑free survival (PFS) time than those without such alterations. In addition, patients with amplification in three of the four chromosomal regions 8p11.21, 8p11.22, 12p13.31 and 20q13.2 had shorter overall survival (OS). We also demonstrated that amplification of 12p13.3 or three of the four chromosomal regions 8p11.21, 8p11.22, 12p13.31 and 20q13.2, or a deletion in the chromosomal region 3q26.1 was associated with chemotherapy resistance. Our findings suggest that copy number alterations in 8p11.21‑22, 12p13.31, 20q13.2, 3q26.1, 4q13.2 and 22q11.23 are critical for the development and survival of OCCC.

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