LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells

Corrigendum in: /10.3892/or.2018.6495

  • Authors:
    • Ye Wei
    • Tiantian Han
    • Ranran Wang
    • Jing Wei
    • Ke Peng
    • Qiong Lin
    • Genbao Shao
  • View Affiliations

  • Published online on: May 10, 2018     https://doi.org/10.3892/or.2018.6432
  • Pages: 425-433
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lysine-specific demethylase 1 (LSD1) plays a key role in cell proliferation, differentiation and carcinogenesis. In the present study we revealed that LSD1 functioned as an autophagy suppressor in ovarian cancer HO8910 cells. Pharmacological inhibition or genetic knockdown of LSD1 resulted in the elevation of the LC3‑II protein, enhancement of autophagosomal formation and stimulation of the autophagic flux. In addition, knockdown of LSD1 further promoted the serum starvation- and rapamycin-induced autophagy. Furthermore, we demonstrated that LSD1 regulated autophagy via the mTOR signaling pathway. Collectively, our findings identified LSD1 as a novel negative regulator of autophagy through the mTOR signaling pathway in ovarian cancer HO8910 cells and indicated that LSD1 may function as a driving factor of ovarian cancer progression via deregulating autophagy.
View Figures
View References

Related Articles

Journal Cover

July-2018
Volume 40 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wei Y, Han T, Wang R, Wei J, Peng K, Lin Q and Shao G: LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells Corrigendum in /10.3892/or.2018.6495. Oncol Rep 40: 425-433, 2018.
APA
Wei, Y., Han, T., Wang, R., Wei, J., Peng, K., Lin, Q., & Shao, G. (2018). LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells Corrigendum in /10.3892/or.2018.6495. Oncology Reports, 40, 425-433. https://doi.org/10.3892/or.2018.6432
MLA
Wei, Y., Han, T., Wang, R., Wei, J., Peng, K., Lin, Q., Shao, G."LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells Corrigendum in /10.3892/or.2018.6495". Oncology Reports 40.1 (2018): 425-433.
Chicago
Wei, Y., Han, T., Wang, R., Wei, J., Peng, K., Lin, Q., Shao, G."LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells Corrigendum in /10.3892/or.2018.6495". Oncology Reports 40, no. 1 (2018): 425-433. https://doi.org/10.3892/or.2018.6432