1
|
Kamisawa T, Wood LD, Itoi T and Takaori K:
Pancreatic cancer. Lancet. 388:73–85. 2016. View Article : Google Scholar : PubMed/NCBI
|
2
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI
|
3
|
Rhim AD, Mirek ET, Aiello NM, Maitra A,
Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK,
Vonderheide RHM, et al: EMT and dissemination precede pancreatic
tumor formation. Cell. 148:349–361. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
De Craene B and Berx G: Regulatory
networks defining EMT during cancer initiation and progression. Nat
Rev Cancer. 13:97–110. 2013. View
Article : Google Scholar : PubMed/NCBI
|
5
|
Apte MV, Wilson JS, Lugea A and Pandol SJ:
A starring role for stellate cells in the pancreatic cancer
microenvironment. Gastroenterology. 144:1210–1219. 2013. View Article : Google Scholar : PubMed/NCBI
|
6
|
Feig C, Gopinathan A, Neesse A, Chan DS,
Cook N and Tuveson DA: The pancreas cancer microenvironment. Clin
Cancer Res. 18:4266–4276. 2012. View Article : Google Scholar : PubMed/NCBI
|
7
|
Mantovani A: Cancer: Inflaming metastasis.
Nature. 457:36–37. 2009. View
Article : Google Scholar : PubMed/NCBI
|
8
|
Wen F, Shen A, Choi A, Gerner EW and Shi
J: Extracellular DNA in pancreatic cancer promotes cell invasion
and metastasis. Cancer Res. 73:4256–4266. 2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Cano CE and Iovanna JL: Stress proteins
and pancreatic cancer metastasis. Scientific World Journal.
10:1958–1966. 2010. View Article : Google Scholar : PubMed/NCBI
|
10
|
Cen P, Ni X, Yang J, Graham DY and Li M:
Circulating tumor cells in the diagnosis and management of
pancreatic cancer. Biochim Biophys Acta. 1826:350–356.
2012.PubMed/NCBI
|
11
|
Franco-Chuaire ML, Magda Carolina SC and
Chuaire-Noack L: Epithelial-mesenchymal transition (EMT):
Principles and clinical impact in cancer therapy. Invest Clin.
54:86–205. 2013.
|
12
|
Jiang X, Rieder S, Giese NA, Friess H,
Michalski CW and Kleeff J: Reduced alpha-dystroglycan expression
correlates with shortened patient survival in pancreatic cancer. J
Surg Res. 171:120–126. 2011. View Article : Google Scholar : PubMed/NCBI
|
13
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI
|
14
|
Vaupel P and Mayer A: Hypoxia in cancer:
Significance and impact on clinical outcome. Cancer Metastasis Rev.
26:225–239. 2007. View Article : Google Scholar : PubMed/NCBI
|
15
|
Koong AC, Mehta VK, Le QT, Fisher GA,
Terris DJ, Brown JM, Bastidas AJ and Vierra M: Pancreatic tumors
show high levels of hypoxia. Int J Radiat Oncol Biol Phys.
48:919–922. 2002. View Article : Google Scholar
|
16
|
Dhani NC, Serra S, Pintilie M, Schwock J,
Xu J, Gallinger S, Hill RP and Hedley DW: Analysis of the intra-
and intertumoral heterogeneity of hypoxia in pancreatic cancer
patients receiving the nitroimidazole tracer pimonidazole. Br J
Cancer. 113:864–871. 2015. View Article : Google Scholar : PubMed/NCBI
|
17
|
Erkan M, Reiser-Erkan C, Michalski CW,
Deucker S, Sauliunaite D, Streit S, Esposito I, Friess H and Kleeff
J: Cancer-stellate cell interactions perpetuate the
hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma.
Neoplasia. 11:497–508. 2009. View Article : Google Scholar : PubMed/NCBI
|
18
|
Samkharadze T, Erkan M, Reiser-Erkan C,
Demir IE, Kong B, Ceyhan GO, Michalski CW, Esposito I, Friess H and
Kleeff J: Pigment epithelium-derived factor associates with
neuropathy and fibrosis in pancreatic cancer. Am J Gastroenterol.
106:968–980. 2011. View Article : Google Scholar : PubMed/NCBI
|
19
|
Lei J, Ma J, Ma Q, Li X, Liu H, Xu Q, Duan
W, Sun Q, Xu J, Wu Z and Wu E: Hedgehog signaling regulates hypoxia
induced epithelial to mesenchymal transition and invasion in
pancreatic cancer cells via a ligand-independent manner. Mol
Cancer. 12:662013. View Article : Google Scholar : PubMed/NCBI
|
20
|
Cheng ZX, Sun B, Wang SJ, Gao Y, Zhang YM,
Zhou HX, Jia G, Wang YW, Kong R, Pan SH, et al: Nuclear
factor-kappaB-dependent epithelial to mesenchymal transition
induced by HIF-1alpha activation in pancreatic cancer cells under
hypoxic conditions. PLoS One. 6:e237522011. View Article : Google Scholar : PubMed/NCBI
|
21
|
Zhu H, Wang D, Zhang L, Xie X, Wu Y, Liu
Y, Shao G and Su Z: Upregulation of autophagy by hypoxia-inducible
factor-1α promotes EMT and metastatic ability of CD133+
pancreatic cancer stem-like cells during intermittent hypoxia.
Oncol Rep. 32:935–942. 2014. View Article : Google Scholar : PubMed/NCBI
|
22
|
Salnikov AV, Liu L, Platen M, Gladkich J,
Salnikova O, Ryschich E, Mattern J, Moldenhauer G, Werner J and
Schemmer P: Hypoxia induces EMT in low and highly aggressive
pancreatic tumor cells but only cells with cancer stem cell
characteristics acquire pronounced migratory potential. PloS One.
7:e463912012. View Article : Google Scholar : PubMed/NCBI
|
23
|
Zhang Q, Lou Y, Zhang J, Fu Q, Wei T, Sun
X, Chen Q, Yang J, Bai X and Liang T: Hypoxia-inducible
factor-2alpha promotes tumor progression and has crosstalk with
Wnt/beta-catenin signaling in pancreatic cancer. Mol Cancer.
16:1192017. View Article : Google Scholar : PubMed/NCBI
|
24
|
Erkan M, Kurtoglu M and Kleeff J: The role
of hypoxia in pancreatic cancer: A potential therapeutic target?
Expert Rev Gastroenterol Hepatol. 10:301–316. 2016. View Article : Google Scholar : PubMed/NCBI
|
25
|
van Roy F: Beyond E-cadherin: Roles of
other cadherin superfamily members in cancer. Nat Rev Cancer.
14:121–134. 2014. View
Article : Google Scholar : PubMed/NCBI
|
26
|
Hoffman BD and Yap AS: Towards a dynamic
understanding of cadherin-based mechanobiology. Trends Cell Biol.
25:803–814. 2015. View Article : Google Scholar : PubMed/NCBI
|
27
|
Lecuit T and Yap AS: E-cadherin junctions
as active mechanical integrators in tissue dynamics. Nat Cell Biol.
17:533–539. 2015. View
Article : Google Scholar : PubMed/NCBI
|
28
|
Kotiyal S and Bhattacharya S: Events of
molecular changes in epithelial-mesenchymal transition. Crit Rev
Eukaryot Gene Expr. 26:163–171. 2016. View Article : Google Scholar : PubMed/NCBI
|
29
|
Qian X, Anzovino A, Kim S, Suyama K, Yao
J, Hulit J, Agiostratidou G, Chandiramani N, McDaid HM, Nagi C, et
al: N-cadherin/FGFR promotes metastasis through
epithelial-to-mesenchymal transition and stem/progenitor cell-like
properties. Oncogene. 33:3411–3421. 2014. View Article : Google Scholar : PubMed/NCBI
|
30
|
Beuran M, Negoi I, Paun S, Ion AD, Bleotu
C, Negoi RI and Hostiuc S: The epithelial to mesenchymal transition
in pancreatic cancer: A systematic review. Pancreatology.
5:217–225. 2015. View Article : Google Scholar
|
31
|
Xie D and Xie K: Pancreatic cancer stromal
biology and therapy. Genes Dis. 2:133–143. 2015. View Article : Google Scholar : PubMed/NCBI
|
32
|
Kim YR, Park MK, Kang GJ, Kim HJ, Kim EJ,
Byun HJ, Lee MY and Lee CH: Leukotriene B4 induces EMT and vimentin
expression in PANC-1 pancreatic cancer cells: Involvement of BLT2
via ERK2 activation. Prostaglandins Leukot Essent Fatty Acids.
115:67–76. 2016. View Article : Google Scholar : PubMed/NCBI
|
33
|
Hilbig A and Oettle H: Transforming growth
factor beta in pancreatic cancer. Curr Pharm Biotechnol.
12:2158–2164. 2011. View Article : Google Scholar : PubMed/NCBI
|
34
|
Melzer C, Hass R, von der Ohe J, Lehnert H
and Ungefroren H: The role of TGF-beta and its crosstalk with
RAC1/RAC1b signaling in breast and pancreas carcinoma. Cell Commn
Signal. 15:192017. View Article : Google Scholar
|