1
|
Wong RS: Apoptosis in cancer: From
pathogenesis to treatment. J Exp Clin Cancer Res. 30:872011.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Ferrín G, Linares CL and Muntané J:
Mitochondrial drug targets in cell death and cancer. Curr Pharm
Design. 17:2002–2016. 2011. View Article : Google Scholar
|
3
|
Dong X, Fu J, Yin X, Yang CJ and Ni J:
Aloe-emodin induces apoptosis in human liver HL-7702 cells through
Fas death pathway and the mitochondrial pathway by generating
reactive oxygen species. Phytother Res. 31:927–936. 2017.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Bhimani RS, Troll W, Grunberger D and
Frenkel K: Inhibition of oxidative stress in HeLa cells by
chemopreventive agents. Cancer Res. 53:4528–4533. 1993.PubMed/NCBI
|
5
|
Wu CC and Bratton S: Regulation of the
intrinsic apoptosis pathway by reactive oxygen species. Antioxid
Redox Sign. 19:546–558. 2013. View Article : Google Scholar
|
6
|
D'Autréaux B and Toledano MB: ROS as
signalling molecules: Mechanisms that generate specificity in ROS
homeostasis. Nat Rev Mol Cell Bio. 8:813–824. 2007. View Article : Google Scholar
|
7
|
Tomek MT, Akiyama T and Dass CR: Role of
Bcl-2 in tumour cell survival and implications for pharmacotherapy.
J Pharm Pharmacol. 64:1695–1702. 2012. View Article : Google Scholar : PubMed/NCBI
|
8
|
Krieser RJ and Eastman A: Cleavage and
nuclear translocation of the caspase 3 substrate Rho
GDP-dissociation inhibitor, D4-GDI, during apoptosis. Cell Death
Differ. 6:412–419. 1999. View Article : Google Scholar : PubMed/NCBI
|
9
|
Wang JB, Zhao HP, Zhao YL, Jin C, Liu DJ,
Kong WJ, Zhang L, Wang HJ and Xiao XH: Hepatotoxicity or
hepatoprotection? Pattern recognition for the paradoxical effect of
the Chinese herb Rheum palmatum L. in treating rat liver
injury. PLoS One. 6:e244982011. View Article : Google Scholar : PubMed/NCBI
|
10
|
Lee MH, Kao L and Lin C: Comparison of the
antioxidant and transmembrane permeative activities of the
different Polygonum cuspidatum extracts in
phospholipid-based microemulsions. J Agr Food Chem. 59:9135–9141.
2011. View Article : Google Scholar
|
11
|
Wang M, Zhao R, Wang W, Mao X and Yu J:
Lipid regulation effects of Polygoni Multiflori Radix, its
processed products and its major substances on steatosis human
liver cell line L02. J Ethnopharmacol. 139:287–293. 2012.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Panigrahi GK, Ch R, Mudiam MK, Vashishtha
VM, Raisuddin S and Das M: Activity-guided chemo toxic profiling of
Cassia occidentalis (CO) seeds: Detection of toxic compounds
in body fluids of CO-exposed patients and experimental rats. Chem
Res Toxicol. 28:1120–1132. 2015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Liu A, Chen H, Wei W, Ye S, Liao W, Gong
J, Jiang Z, Wang L and Lin S: Antiproliferative and antimetastatic
effects of emodin on human pancreatic cancer. Oncol Rep. 26:81–89.
2011.PubMed/NCBI
|
14
|
Huang PH, Huang CY, Chen MC, Lee YT, Yue
CH, Wang HY and Lin H: Emodin and aloe-emodin suppress breast
cancer cell proliferation through ERα inhibition. Evid-Based
Complement Alternat Med. 2013:3761232013. View Article : Google Scholar : PubMed/NCBI
|
15
|
Lin W, Zhong M, Yin H, Chen Y, Cao Q, Wang
C and Ling C: Emodin induces hepatocellular carcinoma cell
apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and
in vivo. Oncol Rep. 36:961–967. 2016. View Article : Google Scholar : PubMed/NCBI
|
16
|
Su J, Yan Y, Qu J, Xue X, Liu Z and Cai H:
Emodin induces apoptosis of lung cancer cells through ER stress and
the TRIB3/NF-κB pathway. Oncol Rep. 37:1565–1572. 2017. View Article : Google Scholar : PubMed/NCBI
|
17
|
Sun Z and BU P: Downregulation of
phosphatase of regenerating liver-3 is involved in the inhibition
of proliferation and apoptosis induced by emodin in the SGC-7901
human gastric carcinoma cell line. Exp Ther Med. 3:1077–1081. 2012.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Cha TL, Qiu L, Chen CT, Wen Y and Hung MC:
Emodin down-regulates androgen receptor and inhibits prostate
cancer cell growth. Cancer Res. 65:2287–2295. 2005. View Article : Google Scholar : PubMed/NCBI
|
19
|
Schwarz S, Wang K, Yu W, Sun B and Schwarz
W: Emodin inhibits current through SARS-associated coronavirus 3a
protein. Antivir Res. 90:64–69. 2011. View Article : Google Scholar : PubMed/NCBI
|
20
|
Chukwujekwu JC, Coombes PH, Mulholland DA
and Staden J: Emodin, an antibacterial anthraquinone from the roots
of Cassia occidentalis. S Afr J Bot. 72:295–297. 2006.
View Article : Google Scholar
|
21
|
Wang W, Zhou Q, Liu L and Zou K:
Anti-allergic activity of emodin on IgE-mediated activation in
RBL-2H3 cells. Pharmacol Rep. 64:1216–1222. 2012. View Article : Google Scholar : PubMed/NCBI
|
22
|
Yang F, Yuan PW, Hao YQ and Lu ZM: Emodin
enhances osteogenesis and inhibits adipogenesis. BMC Complement
Altern Med. 14:742014. View Article : Google Scholar : PubMed/NCBI
|
23
|
Song P, Kim JH, Ghim J, Yoon JH, Lee A,
Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, et al: Emodin
regulates glucose utilization by activating AMP-activated protein
kinase. J Biol Chem. 288:5732–5742. 2013. View Article : Google Scholar : PubMed/NCBI
|
24
|
Liu YX, Shen NY, Liu C and Lv Y:
Immunosuppressive effects of emodin: An in vivo and in vitro study.
Transplant Proc. 41:1837–1839. 2009. View Article : Google Scholar : PubMed/NCBI
|
25
|
Gao Y, Liu H, Deng L, Zhu G, Xu C, Li G,
Liu S, Xie J, Liu J, Kong F, et al: Effect of emodin on neuropathic
pain transmission mediated by P2X2/3 receptor of primary sensory
neurons. Brain Res Bull. 84:406–413. 2011. View Article : Google Scholar : PubMed/NCBI
|
26
|
National Toxicology Program, . NTP
Toxicology and carcinogenesis studies of Emodin (CAS NO. 518-82-1)
feed studies in F344/N rats and B6C3F1 mice. Natl Toxicol Program
Tech Rep Ser. 493:1–278. 2001.PubMed/NCBI
|
27
|
Müller SO, Eckert I, Lutz WK and Stopper
H: Genotoxicity of the laxative drug components emodin, aloe-emodin
and danthron in mammalian cells: Topoisomerase II mediated? Mutat
Res. 371:165–173. 1996. View Article : Google Scholar : PubMed/NCBI
|
28
|
Panigrahi GK, Suthar MK, Verma N, Asthana
S, Tripathi A, Gupta SK, Saxena JK, Raisuddin S and Das M:
Investigation of the interaction of anthraquinones of Cassia
occidentalis seeds with bovine serum albumin by molecular
docking and spectroscopic analysis: Correlation to their in vitro
cytotoxic potential. Food Res Int. 77:368–377. 2015. View Article : Google Scholar
|
29
|
Wang JB, Ma YG, Zhang P, Jin C, Sun YQ,
Xiao XH, Zhao YL and Zhou CP: Effect of processing on the chemical
contents and hepatic and renal toxicity of rhubarb studied by
canonical correlation analysis. Yao Xue Xue Bao. 44:885–890.
2009.(In Chinese). PubMed/NCBI
|
30
|
Andersson TB, Kanebratt KP and Kenna JG:
The HepaRG cell line: A unique in vitro tool for understanding drug
metabolism and toxicology in human. Expert Opin Drug Metab Toxicol.
8:909–920. 2012. View Article : Google Scholar : PubMed/NCBI
|
31
|
Anthérieu S, Chesné C, Li R,
Guguen-Guillouzo C and Guillouzoa A: Optimization of the HepaRG
cell model for drug metabolism and toxicity studies. Toxicol In
Vitro. 26:1278–1285. 2012. View Article : Google Scholar : PubMed/NCBI
|
32
|
Wang C, Wu X, Chen M, Duan W, Sun L, Yan M
and Zhang L: Emodin induces apoptosis through caspase 3-dependent
pathway in HK-2 cells. Toxicology. 231:120–128. 2007. View Article : Google Scholar : PubMed/NCBI
|
33
|
Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E,
Sun Y, Guo X, Zou B, Wang H, et al: 7-O-Geranylquercetin induces
apoptosis in gastric cancer cells via ROS-MAPK mediated
mitochondrial signaling pathway activation. Biomed Pharmacothe.
87:527–538. 2017. View Article : Google Scholar
|
34
|
Zuo D, Duan Z, Jia Y, Chu T, He Q, Yuan J,
Dai W, Li Z, Xing L and Wu Y: Amphipathic silica nanoparticles
induce cytotoxicity through oxidative stress mediated and p53
dependent apoptosis pathway in human liver cell line HL-7702 and
rat liver cell line BRL-3A. Colloids Surf B Biointerfaces.
145:232–240. 2016. View Article : Google Scholar : PubMed/NCBI
|
35
|
Wang J, Wang QL, Nong XH, Zhang XY, Xu XY,
Qi SH and Wang YF: Oxalicumone A, a new dihydrothiophene-condensed
sulfur chromone induces apoptosis in leukemia cells through
endoplasmic reticulum stress pathway. Eur J Pharmacol. 783:47–55.
2016. View Article : Google Scholar : PubMed/NCBI
|
36
|
Zhao Y, Zhang C and Suo Y: MMPT as a
reactive oxygen species generator induces apoptosis via the
depletion of intracellular GSH contents in A549 cells. Eur J
Pharmacol. 688:6–13. 2012. View Article : Google Scholar : PubMed/NCBI
|
37
|
Wang C, Dai X, Liu H, Yi H, Zhou D, Liu C,
Ma M, Jiang Z and Zhang L: Involvement of PPARγ in emodin-induced
HK-2 cell apoptosis. Toxicol In Vitro. 29:228–233. 2015. View Article : Google Scholar : PubMed/NCBI
|
38
|
Huang H, Liu C, Fu X, Zhang S, Xin Y, Li
Y, Xue L, Cheng X and Zhang H: Microcystin-LR induced apoptosis in
rat sertoli cells via the mitochondrial caspase-dependent pathway:
Role of reactive oxygen species. Front Physiol. 7:3972016.
View Article : Google Scholar : PubMed/NCBI
|
39
|
Li Y, Luan Y, Qi X, Li M, Gong L, Xue X,
Wu X, Wu Y, Chen M, Xing G, et al: Emodin triggers DNA
double-strand breaks by stabilizing topoisomerase II-DNA cleavage
complexes and by inhibiting ATP hydrolysis of topoisomerase II.
Toxicol Sci. 118:435–443. 2010. View Article : Google Scholar : PubMed/NCBI
|
40
|
Oshida K, Hirakata M, Maeda A, Miyoshi T
and Miyamoto Y: Toxicological effect of emodin in mouse testicular
gene expression profile. J Appl Toxicol. 31:790–800. 2011.
View Article : Google Scholar : PubMed/NCBI
|
41
|
Lin L, Lin H, Zhang M, Ni B, Yin X, Qu C
and Ni J: A novel method to analyze hepatotoxic components in
Polygonum multiflorum using ultra-performance liquid
chromatography-quadrupole time-of-flight mass spectrometry. J
Hazard Mater. 299:249–259. 2015. View Article : Google Scholar : PubMed/NCBI
|
42
|
Ma J, Zheng L, He YS and Li HY:
Hepatotoxic assessment of Polygoni Multiflori Radix extract and
toxicokinetic study of stilbene glucoside and anthraquinones in
rats. J Ethnopharmacol. 162:61–68. 2015. View Article : Google Scholar : PubMed/NCBI
|
43
|
Martindale JL and Holbrook NJ: Cellular
response to oxidative stress: Signaling for suicide and survival. J
Cell Physiol. 192:1–15. 2002. View Article : Google Scholar : PubMed/NCBI
|
44
|
Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y,
Qi Y and Han X: Dioscin, a natural steroid saponin, induces
apoptosis and DNA damage through reactive oxygen species: A
potential new drug for treatment of glioblastoma multiforme. Food
Chem Toxicol. 59:657–669. 2013. View Article : Google Scholar : PubMed/NCBI
|
45
|
Dong X, Fu J, Yin X, Qu C, He H, Yang C
and Ni J: Induction of apoptosis in HepaRG cell line by Aloe-Emodin
through generation of reactive oxygen species and the mitochondrial
pathway. Cell Physiol Biochem. 42:685–696. 2017. View Article : Google Scholar : PubMed/NCBI
|
46
|
Heimlich G, McKinnon AD, Bernardo K,
Brdiczka D, Reed JC, Kain R, Krönke M and Jürgensmeier JM:
Bax-induced cytochrome c release from mitochondria depends
on alpha-helices-5 and −6. Biochem J. 378:247–255. 2004. View Article : Google Scholar : PubMed/NCBI
|
47
|
Ying J, Xu H, Wu D and Wu X: Emodin
induces apoptosis of human osteosarcoma cells via mitochondria- and
endoplasmic reticulum stress-related pathways. Int J Clin Exp
Patho. 8:12837–12844. 2015.
|
48
|
Ma L and Li WS: Emodin inhibits LOVO
colorectal cancer cell proliferation via the regulation of the
Bcl-2/Bax ratio and cytochrome c. Exp Ther Med. 8:1225–1228.
2014. View Article : Google Scholar : PubMed/NCBI
|
49
|
Xie MJ, Ma YH, Miao L, Wang Y, Wang HZ,
Xing YY, Xi T and Lu YY: Emodin-provoked oxidative stress induces
apoptosis in human colon cancer HCT116 cells through a
p53-mitochondrial apoptotic pathway. Asian Pac J Cancer Prev.
15:5201–5205. 2014. View Article : Google Scholar : PubMed/NCBI
|
50
|
Cui Y, Lu P, Ge S, Liu Q, Zhu D and Liu X:
Involvement of PI3K/Akt, ERK and p38 signaling pathways in
emodin-mediated extrinsic and intrinsic human hepatoblastoma cell
apoptosis. Food Chem Toxicol. 92:26–37. 2016. View Article : Google Scholar : PubMed/NCBI
|