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UCA1 overexpression is associated with less aggressive subtypes of bladder cancer

  • Authors:
    • Laetitia Lebrun
    • Dina Milowich
    • Marie Le Mercier
    • Justine Allard
    • Yves‑Rémi Van Eycke
    • Thierry Roumeguere
    • Christine Decaestecker
    • Isabelle Salmon
    • Sandrine Rorive

  • View Affiliations

  • Published online on: September 10, 2018     https://doi.org/10.3892/or.2018.6697
  • Pages: 2497-2506

  • Copyright: © Lebrun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑coding RNAs (ncRNAs) have been shown to serve important roles in carcinogenesis via complex mechanisms, including transcriptional and post‑transcriptional regulation, and chromatin interactions. Urothelial carcinoma‑associated 1 (UCA1), a long ncRNA, was recently shown to have tumorigenic properties in urothelial bladder cancer (UBC), as demonstrated by enhanced proliferation, migration, invasion and therapy resistance of UBC cell lines in vitro. These in vitro findings suggested that UCA1 is associated with aggressive tumor behavior and could have prognostic implications in UBC. The aims of the present study were to therefore to investigate the statistical associations between UCA1 RNA expression and UBC pathological features, patient prognosis and p53 and Ki‑67 expression. Chromogenic in situ hybridization and immunohistochemistry were performed on UBC tissue microarrays to characterize UCA1 RNA, and p53 and Ki‑67 expression in 208 UBC cases, including 145 non‑muscle‑invasive and 63 muscle‑invasive cases. UCA1 was observed in the tumor cells of 166/208 (80%) UBC cases tested. No expression was noted in normal stromal and endothelium cells. Patients with UBC that overexpressed UCA1 (35%) had a significantly higher survival rate (P=0.006) compared with that in patients with UBC that did not overexpress UCA1. This prognostic factor was independent of tumor morphology, concomitant carcinoma in situ, tumor grade and tumor stage. In addition, the absence of UCA1 overexpression was significantly associated with a high Ki‑67 proliferative index (P=0.008) and a p53 'mutated' immunoprofile (strong nuclear expression or complete absence of staining; P=0.003). In conclusion, the present results identified UCA1 as potentially being a novel independent prognostic marker in UBC that was associated with a better patient prognosis and that could serve a pivotal role in bladder cancer carcinogenesis.
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November-2018
Volume 40 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lebrun L, Milowich D, Le Mercier M, Allard J, Van Eycke YR, Roumeguere T, Decaestecker C, Salmon I and Rorive S: UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncol Rep 40: 2497-2506, 2018.
APA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T. ... Rorive, S. (2018). UCA1 overexpression is associated with less aggressive subtypes of bladder cancer. Oncology Reports, 40, 2497-2506. https://doi.org/10.3892/or.2018.6697
MLA
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40.5 (2018): 2497-2506.
Chicago
Lebrun, L., Milowich, D., Le Mercier, M., Allard, J., Van Eycke, Y., Roumeguere, T., Decaestecker, C., Salmon, I., Rorive, S."UCA1 overexpression is associated with less aggressive subtypes of bladder cancer". Oncology Reports 40, no. 5 (2018): 2497-2506. https://doi.org/10.3892/or.2018.6697