Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis

  • Authors:
    • Jiguang Ma
    • Mengwen Xue
    • Simei Zhang
    • Liang Cheng
    • Weikun Qian
    • Wanxing Duan
    • Xin Shen
  • View Affiliations

  • Published online on: November 28, 2018     https://doi.org/10.3892/or.2018.6894
  • Pages: 1051-1058
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Abstract

Resveratrol is a type of polyphenol that is abundantly present in knotweed and grapes, and has been confirmed to have tumor‑inhibitory properties. However, the effect of resveratrol on tumor cells under chronic stress conditions remains unclear. The aim of the present study was to demonstrate that resveratrol exerts a significant inhibitory effect on the growth and proliferation of tumor cells under chronic stress in a dose‑dependent manner. Furthermore, resveratrol was able to induce apoptosis of cancer cells under chronic stress conditions. Moreover, resveratrol was found to inhibit tumor cells under chronic stress by decreasing the expression of the β2‑adrenergic receptor (ADRB‑2); in addition, the protein expression of hypoxia‑inducible factor (HIF)‑1α was suppressed by resveratrol in a dose‑dependent manner. Thus, these data suggest that resveratrol inhibits the growth of cancer cells under chronic stress by regulating the ADRB‑2‑HIF‑1α axis. In summary, the present study may provide a new basis supporting the use of resveratrol for the prevention and treatment of pancreatic cancer.
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February-2019
Volume 41 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ma J, Xue M, Zhang S, Cheng L, Qian W, Duan W and Shen X: Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis. Oncol Rep 41: 1051-1058, 2019.
APA
Ma, J., Xue, M., Zhang, S., Cheng, L., Qian, W., Duan, W., & Shen, X. (2019). Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis. Oncology Reports, 41, 1051-1058. https://doi.org/10.3892/or.2018.6894
MLA
Ma, J., Xue, M., Zhang, S., Cheng, L., Qian, W., Duan, W., Shen, X."Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis". Oncology Reports 41.2 (2019): 1051-1058.
Chicago
Ma, J., Xue, M., Zhang, S., Cheng, L., Qian, W., Duan, W., Shen, X."Resveratrol inhibits the growth of tumor cells under chronic stress via the ADRB‑2‑HIF‑1α axis". Oncology Reports 41, no. 2 (2019): 1051-1058. https://doi.org/10.3892/or.2018.6894