Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma

  • Authors:
    • Wei Xiang
    • Tao Peng
    • Yang Ming
    • Shenjie Li
    • Ke Wang
    • Haorun Wang
    • Ligang Chen
    • Jie Zhou
  • View Affiliations

  • Published online on: February 13, 2019     https://doi.org/10.3892/or.2019.7009
  • Pages: 2464-2470
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Myristoylated alanine‑rich C‑kinase substrate (MARCKS) serves an important role in various pathological processes in several malignancies. However, little is known about the specific role and molecular mechanism of MARCKS in glioblastoma (GBM). In the present study, it was found that the expression of MARCKS was significantly upregulated in GBM, and was associated with a poor clinical outcome in patients with GBM. Knockdown of MARCKS suppressed the migration and invasion of GBM cells in vitro. Western blotting showed that the knockdown of MARCKS reduced the expression of phosphorylated phosphoinositide 3‑kinase and protein kinase B, as well as zinc finger protein SNAI1 expression, thereby modulating the expression of its downstream epithelial‑mesenchymal transition (EMT)‑associated factors, including E‑cadherin, vimentin, N‑cadherin and β‑catenin in GBM cells. These results indicate that MARCKS functioned in the migration and invasion of GBM, and therefore may provide a potential therapeutic target in GBM therapy.
View Figures
View References

Related Articles

Journal Cover

April-2019
Volume 41 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiang W, Peng T, Ming Y, Li S, Wang K, Wang H, Chen L and Zhou J: Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma. Oncol Rep 41: 2464-2470, 2019.
APA
Xiang, W., Peng, T., Ming, Y., Li, S., Wang, K., Wang, H. ... Zhou, J. (2019). Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma. Oncology Reports, 41, 2464-2470. https://doi.org/10.3892/or.2019.7009
MLA
Xiang, W., Peng, T., Ming, Y., Li, S., Wang, K., Wang, H., Chen, L., Zhou, J."Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma". Oncology Reports 41.4 (2019): 2464-2470.
Chicago
Xiang, W., Peng, T., Ming, Y., Li, S., Wang, K., Wang, H., Chen, L., Zhou, J."Myristoylated alanine rich protein kinase C substrate is a potential cancer prognostic factor that regulates cell migration and invasion in glioblastoma". Oncology Reports 41, no. 4 (2019): 2464-2470. https://doi.org/10.3892/or.2019.7009