Open Access

Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer

  • Authors:
    • Jiao Wang
    • Zhi‑Guo Hu
    • Dan Li
    • Ji‑Xion Xu
    • Zhen‑Guo Zeng
  • View Affiliations

  • Published online on: September 16, 2019     https://doi.org/10.3892/or.2019.7314
  • Pages: 1981-1995
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Lung cancer is the leading cause of cancer mortality worldwide. Approximately 85% of all lung cancer cases are classified as non‑small cell lung cancer (NSCLC). Currently, there is no standard method to predict the survival of patients with NSCLC. Insulin‑like growth factor‑binding proteins (IGFBPs) function as modulators of IGF signaling and are attracting increasing attention for their role in NSCLC. However, the prognostic values of individual IGFBPs in NSCLC, particularly at the mRNA level, remain unknown. In the present study, the distinct expression patterns and prognostic values of IGFBP family members in patients with NSCLC through bioinformatics analysis were reported using a series of databases, including Gene Expression Profiling Interactive Analysis, Kaplan‑Meier Plotter, cBioPortal, GeneMANIA, and the Database for Annotation, Visualization and Integrated Discovery. In patients with NSCLC, IGFBP2 and IGFBP3 were significantly upregulated, while IGFBP6 was downregulated. High IGFBP1/2/4 expression was correlated with poor overall survival (OS) in all NSCLC types, especially adenocarcinoma; however, high IGFBP2/5 expression was significantly correlated with favorable OS only in patients with squamous cell carcinoma. In addition, aberrant IGFBP1/2/3/4/5 mRNA levels were associated with the prognosis of subsets of NSCLC with different clinicopathological features. These results indicated that various IGFBPs can serve as useful prognostic biomarkers and as potential targets for NSCLC therapies.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 42 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Hu ZG, Li D, Xu JX and Zeng ZG: Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncol Rep 42: 1981-1995, 2019.
APA
Wang, J., Hu, Z., Li, D., Xu, J., & Zeng, Z. (2019). Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer. Oncology Reports, 42, 1981-1995. https://doi.org/10.3892/or.2019.7314
MLA
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42.5 (2019): 1981-1995.
Chicago
Wang, J., Hu, Z., Li, D., Xu, J., Zeng, Z."Gene expression and prognosis of insulin‑like growth factor‑binding protein family members in non‑small cell lung cancer". Oncology Reports 42, no. 5 (2019): 1981-1995. https://doi.org/10.3892/or.2019.7314