|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Michl P and Gress TM: Current concepts and
novel targets in advanced pancreatic cancer. Gut. 62:317–326. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Feig C, Gopinathan A, Neesse A, Chan DS,
Cook N and Tuveson DA: The pancreas cancer microenvironment. Clin
Cancer Res. 18:4266–4276. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Quail DF, Bowman RL, Akkari L, Quick ML,
Schuhmacher AJ, Huse JT, Holland EC, Sutton JC and Joyce JA: The
tumor microenvironment underlies acquired resistance to CSF-1R
inhibition in gliomas. Science. 352:62882016. View Article : Google Scholar
|
|
5
|
von Ahrens D, Bhagat TD, Nagrath D, Maitra
A and Verma A: The role of stromal cancer-associated fibroblasts in
pancreatic cancer. J Hematol Oncol. 10:762017. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Helm O, Held-Feindt J, Grage-Griebenow E,
Reiling N, Ungefroren H, Vogel I, Kruger U, Becker T, Ebsen M,
Rocken C, et al: Tumor-associated macrophages exhibit pro- and
anti-inflammatory properties by which they impact on pancreatic
tumorigenesis. Int J Cancer. 135:843–861. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Hwang RF, Moore T, Arumugam T,
Ramachandran V, Amos KD, Rivera A, Ji B, Evans DB and Logsdon CD:
Cancer-associated stromal fibroblasts promote pancreatic tumor
progression. Cancer Re. 68:918–926. 2008. View Article : Google Scholar
|
|
8
|
Bailey JM, Swanson BJ, Hamada T, Eggers
JP, Singh PK, Caffery T, Ouellette MM and Hollingsworth MA: Sonic
hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer
Res. 14:5995–6004. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Deng Y and Scherer PE: Adipokines as novel
biomarkers and regulators of the metabolic syndrome. Ann N Y Acad
Sci. 1212:E1–E19. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xiao Q, Zhou D, Rucki AA, Williams J, Zhou
J, Mo G, Murphy A, Fujiwara K, Kleponis J, Salman B, et al:
Cancer-associated fibroblasts in pancreatic cancer are reprogrammed
by tumor-induced alterations in genomic DNA methylation. Cancer
Res. 76:5395–5404. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Apte MV, Wilson JS, Lugea A and Pandol SJ:
A starring role for stellate cells in the pancreatic cancer
microenvironment. Gastroenterology. 144:1210–1219. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Dirat B, Bochet L, Dabek M, Daviaud D,
Dauvillier S, Majed B, Wang YY, Meulle A, Salles B, Le Gonidec S,
et al: Cancer-associated adipocytes exhibit an activated phenotype
and contribute to breast cancer invasion. Cancer Res. 71:2455–2465.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Bochet L, Lehuede C, Dauvillier S, Wang
YY, Dirat B, Laurent V, Dray C, Guiet R, Maridonneau-Parini I, Le
Gonidec S, et al: Adipocyte-derived fibroblasts promote tumor
progression and contribute to the desmoplastic reaction in breast
cancer. Cancer Res. 73:5657–5668. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Wang YY, Attane C, Milhas D, Dirat B,
Dauvillier S, Guerard A, Gilhodes J, Lazar I, Alet N, Laurent V, et
al: Mammary adipocytes stimulate breast cancer invasion through
metabolic remodeling of tumor cells. JCI Insight. 2:e874892017.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Nieman KM, Kenny HA, Penicka CV, Ladanyi
A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB,
Hotamisligil GS, et al: Adipocytes promote ovarian cancer
metastasis and provide energy for rapid tumor growth. Nat Med.
17:1498–1503. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
16
|
Laurent V, Guerard A, Mazerolles C, Le
Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D,
Socrier Y, et al: Periprostatic adipocytes act as a driving force
for prostate cancer progression in obesity. Nat Commun.
7:102302016. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Hori M, Takahashi M, Hiraoka N, Yamaji T,
Mutoh M, Ishigamori R, Furuta K, Okusaka T, Shimada K, Kosuge T, et
al: Association of pancreatic fatty infiltration with pancreatic
ductal adenocarcinoma. Clin Transl Gastroenterol. 5:e532014.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Rebours V, Gaujoux S, d'Assignies G,
Sauvanet A, Ruszniewski P, Levy P, Paradis V, Bedossa P and
Couvelard A: Obesity and fatty pancreatic infiltration are risk
factors for pancreatic precancerous lesions (PanIN). Clin Cancer
Res. 21:3522–3528. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Incio J, Liu H, Suboj P, Chin SM, Chen IX,
Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, et al: Obesity-Induced
inflammation and desmoplasia promote pancreatic cancer progression
and resistance to chemotherapy. Cancer Discov. 6:852–869. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Okumura T, Ohuchida K, Sada M, Abe T, Endo
S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, et al:
Extra-pancreatic invasion induces lipolytic and fibrotic changes in
the adipose microenvironment, with released fatty acids enhancing
the invasiveness of pancreatic cancer cells. Oncotarget.
8:18280–18295. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Ziegler KM, Considine RV, True E,
Swartz-Basile DA, Pitt HA and Zyromski NJ: Adipocytes enhance
murine pancreatic cancer growth via a hepatocyte growth factor
(HGF)-mediated mechanism. Int J Surg. 28:179–184. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Carbone C, Piro G, Gaianigo N, Ligorio F,
Santoro R, Merz V, Simionato F, Zecchetto C, Falco G, Conti G, et
al: Adipocytes sustain pancreatic cancer progression through a
non-canonical WNT paracrine network inducing ROR2 nuclear
shuttling. Int J Obes (Lond). 42:334–343. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Schneider CA, Rasband WS and Eliceiri KW:
NIH image to imageJ: 25 years of image analysis. Nat Methods.
9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Trapnell C, Williams BA, Pertea G,
Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ and Pachter
L: Transcript assembly and quantification by RNA-Seq reveals
unannotated transcripts and isoform switching during cell
differentiation. Nat Biotechnol. 28:511–515. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Trapnell C, Hendrickson DG, Sauvageau M,
Goff L, Rinn JL and Pachter L: Differential analysis of gene
regulation at transcript resolution with RNA-seq. Nat Biotechnol.
31:46–53. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
26
|
Mao X, Cai T, Olyarchuk JG and Wei L:
Automated genome annotation and pathway identification using the
KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics.
21:3787–3793. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Huang H, Song TJ, Li X, Hu L, He Q, Liu M,
Lane MD and Tang QQ: BMP signaling pathway is required for
commitment of C3H10T1/2 pluripotent stem cells to the adipocyte
lineage. Proce Natl Acad Sci USA. 106:12670–12675. 2009. View Article : Google Scholar
|
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Park J, Morley TS, Kim M, Clegg DJ and
Scherer PE: Obesity and cancer-mechanisms underlying tumour
progression and recurrence. Nat Rev Endocrinol. 10:455–465. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Corsa CAS and MacDougald OA: Cyclical
dedifferentiation and redifferentiation of mammary adipocytes. Cell
Metab. 28:187–189. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Nieto MA, Huang RY, Jackson RA and Thiery
JP: EMT: 2016. Cell. 166:21–45. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Lengyel E, Makowski L, DiGiovanni J and
Kolonin MG: Cancer as a matter of fat: The crosstalk between
adipose tissue and tumors. Trends Cancer. 4:374–384. 2018.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Herman MA, Peroni OD, Villoria J, Schon
MR, Abumrad NA, Bluher M, Klein S and Kahn BB: A novel ChREBP
isoform in adipose tissue regulates systemic glucose metabolism.
Nature. 484:333–338. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Iizuka K, Bruick RK, Liang G, Horton JD
and Uyeda K: Deficiency of carbohydrate response element-binding
protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc
Natl Acad Sci USA. 101:7281–7286. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Sah RP, Nagpal SJ, Mukhopadhyay D and
Chari ST: New insights into pancreatic cancer-induced
paraneoplastic diabetes. Nat Rev Gastroenterol Hepatol. 10:423–433.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hoy AJ, Balaban S and Saunders DN:
Adipocyte-tumor cell metabolic crosstalk in breast cancer. Trends
Mol Med. 23:381–392. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Miranda F, Mannion D, Liu S, Zheng Y,
Mangala LS, Redondo C, Herrero-Gonzalez S, Xu R, Taylor C, Chedom
DF, et al: Salt-inducible kinase 2 couples ovarian cancer cell
metabolism with survival at the adipocyte-rich metastatic niche.
Cancer Cell. 30:273–289. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Marangoni RG, Korman BD, Wei J, Wood TA,
Graham LV, Whitfield ML, Scherer PE, Tourtellotte WG and Varga J:
Myofibroblasts in murine cutaneous fibrosis originate from
adiponectin-positive intradermal progenitors. Arthritis Rheumatol.
67:1062–1073. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Wang QA, Song A, Chen W, Schwalie PC,
Zhang F, Vishvanath L, Jiang L, Ye R, Shao M, Tao C, et al:
Reversible de-differentiation of mature white adipocytes into
preadipocyte-like precursors during lactation. Cell Metab.
28:282–288. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zoico E, Darra E, Rizzatti V, Budui S,
Franceschetti G, Mazzali G, Rossi AP, Fantin F, Menegazzi M, Cinti
S and Zamboni M: Adipocytes WNT5a mediated dedifferentiation: A
possible target in pancreatic cancer microenvironment. Oncotarget.
7:20223–20235. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Zoico E, Darra E, Rizzatti V, Tebon M,
Franceschetti G, Mazzali G, Rossi AP, Fantin F and Zamboni M: Role
of adipose tissue in melanoma cancer microenvironment and
progression. Int J Obes (Lond). 42:344–352. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chirumbolo S and Bjorklund G: Can wnt5a
and wnt non-canonical pathways really mediate adipocyte
de-differentiation in a tumour microenvironment? Eur J Cancer.
64:96–100. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Ye X and Weinberg RA:
Epithelial-mesenchymal plasticity: A central regulator of cancer
progression. Trends Cell Biol. 25:675–686. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Whatcott CJ, Diep CH, Jiang P, Watanabe A,
LoBello J, Sima C, Hostetter G, Shepard HM, Von Hoff DD and Han H:
Desmoplasia in primary tumors and metastatic lesions of pancreatic
cancer. Clin Cancer Res. 21:3561–3568. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Bluher M: Adipose tissue dysfunction in
obesity. Exp Clin Endocrinol Diabetes. 117:241–250. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Khandekar MJ, Cohen P and Spiegelman BM:
Molecular mechanisms of cancer development in obesity. Nat Rev
Cancer. 11:886–895. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Lemoine AY, Ledoux S and Larger E: Adipose
tissue angiogenesis in obesity. Thromb Haemost. 110:661–668. 2013.
View Article : Google Scholar : PubMed/NCBI
|
