Open Access

Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma

  • Authors:
    • Linhe Gan
    • Hao Shen
    • Xinduo Li
    • Zhipeng Han
    • Yingying Jing
    • Xue Yang
    • Mengchao Wu
    • Yong Xia
  • View Affiliations

  • Published online on: November 6, 2020     https://doi.org/10.3892/or.2020.7838
  • Pages: 107-118
  • Copyright: © Gan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intrahepatic cholangiocarcinoma (ICC) is a type of cancer that is difficult to cure; chemoresistance of cholangiocarcinoma cells affect the prognosis of patients who cannot be treated with surgery. The mechanism underlying this chemoresistance remains unknown. Mesenchymal stem cells (MSCs) are known to be important components of the tumor microenvironment. In the present study, a large number of MSCs were observed to infiltrate the tumor sites of ICC; thus, MSCs were isolated from ICC tumor tissues. It was revealed that herpesvirus entry mediator (HVEM) was overexpressed in ICC‑MSCs. The present study then investigated the role of HVEM‑overexpressing MSCs in the chemoresistance of cholangiocarcinoma cells. It was demonstrated that HVEM‑overexpressing MSCs could support cell survival of chemotherapeutic cholangiocarcinoma cells and inhibited their apoptosis. Further investigations revealed that HVEM‑overexpressing MSCs could secrete IL‑6 and also activated AMPK/mTOR‑dependent autophagy of cholangiocarcinoma cells. Thus, it was concluded that ICC‑MSC‑induced autophagy is the primary cause of chemoresistance in ICC.
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January-2021
Volume 45 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Gan L, Shen H, Li X, Han Z, Jing Y, Yang X, Wu M and Xia Y: Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma. Oncol Rep 45: 107-118, 2021.
APA
Gan, L., Shen, H., Li, X., Han, Z., Jing, Y., Yang, X. ... Xia, Y. (2021). Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma. Oncology Reports, 45, 107-118. https://doi.org/10.3892/or.2020.7838
MLA
Gan, L., Shen, H., Li, X., Han, Z., Jing, Y., Yang, X., Wu, M., Xia, Y."Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma". Oncology Reports 45.1 (2021): 107-118.
Chicago
Gan, L., Shen, H., Li, X., Han, Z., Jing, Y., Yang, X., Wu, M., Xia, Y."Mesenchymal stem cells promote chemoresistance by activating autophagy in intrahepatic cholangiocarcinoma". Oncology Reports 45, no. 1 (2021): 107-118. https://doi.org/10.3892/or.2020.7838