IGFBP2 in cancer: Pathological role and clinical significance (Review)

  • Authors:
    • Lai‑Feng Wei
    • Xue‑Fen Weng
    • Xu‑Chun Huang
    • Yu‑Hui Peng
    • Hai‑Peng Guo
    • Yi‑Wei Xu
  • View Affiliations

  • Published online on: December 9, 2020     https://doi.org/10.3892/or.2020.7892
  • Pages: 427-438
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Abstract

The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cancers. In addition, a growing number of studies have shown that IGFBP2 is greatly elevated in serum or tissue in patients with malignant tumors and plays an essential role in several key oncogenic processes, such as tumor cellular proliferation, migration, invasion, angiogenesis, epithelial‑to‑mesenchymal transition, and immunoregulation, which are involved in a variety of signal pathways, usually via an IGF‑independent means. Moreover, growing evidence indicates that aberrant overexpression of IGFBP2 may serve as a useful biomarker for the diagnosis and prognosis of patients, as well as act as a potential therapeutic target for the management of clinical treatment in patients with malignant disease. In the present review, we summarize the current points of view that IGFBP2 performs a role in the initiation and progression of various types of cancer by interacting with several key molecules involved in cancer signaling pathways. We also discuss its potential clinical application value as a diagnostic/prognostic biomarker for patients with malignant tumors.
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February-2021
Volume 45 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Wei LF, Weng XF, Huang XC, Peng YH, Guo HP and Xu YW: IGFBP2 in cancer: Pathological role and clinical significance (Review). Oncol Rep 45: 427-438, 2021.
APA
Wei, L., Weng, X., Huang, X., Peng, Y., Guo, H., & Xu, Y. (2021). IGFBP2 in cancer: Pathological role and clinical significance (Review). Oncology Reports, 45, 427-438. https://doi.org/10.3892/or.2020.7892
MLA
Wei, L., Weng, X., Huang, X., Peng, Y., Guo, H., Xu, Y."IGFBP2 in cancer: Pathological role and clinical significance (Review)". Oncology Reports 45.2 (2021): 427-438.
Chicago
Wei, L., Weng, X., Huang, X., Peng, Y., Guo, H., Xu, Y."IGFBP2 in cancer: Pathological role and clinical significance (Review)". Oncology Reports 45, no. 2 (2021): 427-438. https://doi.org/10.3892/or.2020.7892