Research progress on tumour‑associated macrophages in gastric cancer (Review)

  • Authors:
    • Zidi Zhou
    • Zhilong Yang
    • Jingzhi Wang
    • Qiang Wang
    • Heng Zhang
    • Xiaoli Ju
  • View Affiliations

  • Published online on: February 19, 2021     https://doi.org/10.3892/or.2021.7986
  • Article Number: 35
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Abstract

Tumour‑associated macrophages (TAMs) are immune cells that are present in large numbers in the tumour immune microenvironment. TAMs are important for the occurrence, development, invasion, metastasis and immune escape of tumours. TAMs have become a novel therapeutic target and prognostic indicator in the individualised treatment of patients. Studies have reported that the number of TAMs can predict the size, stage and metastasis of gastric cancer. Therefore, in‑depth examination of TAMs may be important for high‑risk screening, early diagnosis and prognostic judgment of patients with gastric cancer. The present review examined the research progress of TAMs in gastric cancer on the basis of previous literature studies. Moreover, this review systematically evaluated the three major aspects of the differentiation of macrophages, the tumour‑promoting mechanism of TAMs in gastric cancer and the relationship between TAMs and treatment of gastric cancer. Finally, this review aimed to provide a reference for investigating the prognostic indicators and treatment targets of patients with gastric cancer.
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April-2021
Volume 45 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Z, Yang Z, Wang J, Wang Q, Zhang H and Ju X: Research progress on tumour‑associated macrophages in gastric cancer (Review). Oncol Rep 45: 35, 2021.
APA
Zhou, Z., Yang, Z., Wang, J., Wang, Q., Zhang, H., & Ju, X. (2021). Research progress on tumour‑associated macrophages in gastric cancer (Review). Oncology Reports, 45, 35. https://doi.org/10.3892/or.2021.7986
MLA
Zhou, Z., Yang, Z., Wang, J., Wang, Q., Zhang, H., Ju, X."Research progress on tumour‑associated macrophages in gastric cancer (Review)". Oncology Reports 45.4 (2021): 35.
Chicago
Zhou, Z., Yang, Z., Wang, J., Wang, Q., Zhang, H., Ju, X."Research progress on tumour‑associated macrophages in gastric cancer (Review)". Oncology Reports 45, no. 4 (2021): 35. https://doi.org/10.3892/or.2021.7986