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Article

HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis

  • Authors:
    • Jun Wang
    • Feiyan Xiang
    • Xiang Liu
    • Xiang Ma
    • Xiaonan Cai
    • Yuan Yang
    • Xin Shen
    • Chunhui Yuan
    • Yun Xiang
    • Han Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, P.R. China, Institute of Maternal and Child Health, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, P.R. China
  • Article Number: 51
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    Published online on: March 4, 2021
       https://doi.org/10.3892/or.2021.8002
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Abstract

High‑risk human papillomavirus (HPV)16 and 18 are the primary cause of cervical cancer (CC) and long non‑coding RNAs (lncRNAs/lncs) are often abnormally expressed in patients with CC. The authors' previous study indicated that oncogenic enhancer of zeste homolog 2 (EZH2)‑binding lncRNA in cervical cancer (lnc‑EBIC) serves a role in the tumorigenic activity of the HPV E6 protein in patients with CC. However, whether HPV E7 affects the development of CC through lnc‑EBIC, and the potential mechanisms underlying this remains unclear. Therefore, the present study investigated the effects of lnc‑EBIC and HPV E7 in cervical cancer cell lines HeLa, CaSki and C33A in vitro. CCK‑8, EdU and DAPI staining assays, flow cytometry, RT‑qPCR, western blotting and Transwell assay were performed on these cell lines. The results revealed that exogenous expression of HPV16/18 E7 significantly promoted lnc‑EBIC expression, and conversely, lnc‑EBIC was downregulated by silencing endogenous HPV16/18 E7 expression in corresponding CaSki and HeLa cells. Overexpression of lnc‑EBIC significantly increased cellular proliferation, migration and invasion, and inhibited apoptosis in HPV‑ C33A cells. The tumorigenic effects of HPV16/18 E7 in corresponding CaSki and HeLa cells were significantly blocked by the silencing of lnc‑EBIC expression. Molecular analysis revealed that HPV16/18 E7 depended on TAL BHLH transcription factor 1, erythroid differentiation factor inhibition to promote lnc‑EBIC expression, which also resulted in the upregulation of oncogenic Kelch domain‑containing 7B (KLHDC7B) in corresponding CaSki and HeLa cells. Additionally, KLHDC7B knockdown blocked the tumor‑promotive effects of lnc‑EBIC in HPV‑ C33A cells. Collectively, the results of the present study indicated that lnc‑EBIC acts as an oncogenic lncRNA by enhancing KLHDC7B expression in HPV+ and HPV‑ CC cells, and can be exploited by HPV16/18 E7 to accelerate tumorigenic activity in CC. These results further revealed that the lnc‑EBIC/KLHDC7B axis represents a novel molecular mechanism and potential therapeutic target for CC.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. Feb 4–2021.(Online ahead of print). View Article : Google Scholar : PubMed/NCBI

2 

Boda D, Neagu M, Constantin C, Voinescu RN, Caruntu C, Zurac S, Spandidos DA, Drakoulis N, Tsoukalas D and Tsatsakis AM: HPV strain distribution in patients with genital warts in a female population sample. Oncol Lett. 12:1779–1782. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Hoppe-Seyler K, Bossler F, Braun JA, Herrmann AL and Hoppe-Seyler F: The HPV E6/E7 oncogenes: Key factors for viral carcinogenesis and therapeutic targets. Trends Microbiol. 26:158–168. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Dardiotis E, Siokas V, Garas A, Paraskevaidis E, Kyrgiou M, Xiromerisiou G, Deligeoroglou E, Galazios G, Kontomanolis EN, Spandidos DA, et al: Genetic variations in the SULF1 gene alter the risk of cervical cancer and precancerous lesions. Oncol Lett. 16:3833–3841. 2018.PubMed/NCBI

5 

Boda D, Docea AO, Calina D, Ilie MA, Caruntu C, Zurac S, Neagu M, Constantin C, Branisteanu DE, Voiculescu V, et al: Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review). Int J Oncol. 52:637–655. 2018.PubMed/NCBI

6 

Li S, Hong X, Wei Z, Xie M, Li W, Liu G, Guo H, Yang J, Wei W and Zhang S: Ubiquitination of the HPV oncoprotein E6 is critical for E6/E6AP-mediated p53 degradation. Front Microbiol. 10:24832019. View Article : Google Scholar : PubMed/NCBI

7 

Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, et al: Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature. 529:541–545. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Celegato M, Messa L, Goracci L, Mercorelli B, Bertagnin C, Spyrakis F, Suarez I, Cousido-Siah A, Trave G, Banks L, et al: A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth. Cancer Lett. 470:115–125. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Ganti K, Massimi P, Manzo-Merino J, Tomaic V, Pim D, Playford MP, Lizano M, Roberts S, Kranjec C, Doorbar J and Banks L: Interaction of the human papillomavirus E6 oncoprotein with sorting nexin 27 modulates endocytic cargo transport pathways. PLoS Pathog. 12:e10058542016. View Article : Google Scholar : PubMed/NCBI

10 

Hatterschide J, Bohidar AE, Grace M, Nulton TJ, Kim HW, Windle B, Morgan IM, Munger K and White EA: PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis. Proc Natl Acad Sci USA. 116:7033–7042. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Barr JA, Hayes KE, Brownmiller T, Harold AD, Jagannathan R, Lockman PR, Khan S and Martinez I: Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells. Sci Rep. 9:36622019. View Article : Google Scholar : PubMed/NCBI

12 

Sharma S and Munger K: Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) long noncoding RNA is driven by the human papillomavirus E6 protein and modulates cell proliferation independent of PCNA. Virology. 518:8–13. 2018. View Article : Google Scholar : PubMed/NCBI

13 

He H, Liu X, Liu Y, Zhang M, Lai Y, Hao Y, Wang Q, Shi D, Wang N, Luo XG, et al: Human papillomavirus E6/E7 and long noncoding RNA TMPOP2 mutually upregulated gene expression in cervical cancer cells. J Virol. 93:e01808–18. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Dong J, Su M, Chang W, Zhang K, Wu S and Xu T: Long non-coding RNAs on the stage of cervical cancer (Review). Oncol Rep. 38:1923–1931. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Sun NX, Ye C, Zhao Q, Zhang Q, Xu C, Wang SB, Jin ZJ, Sun SH, Wang F and Li W: Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS One. 9:e1003402014. View Article : Google Scholar : PubMed/NCBI

16 

Jeong G, Bae H, Jeong D, Ham J, Park S, Kim HW, Kang HS and Kim SJ: A Kelch domain-containing KLHDC7B and a long non-coding RNA ST8SIA6-AS1 act oppositely on breast cancer cell proliferation via the interferon signaling pathway. Sci Rep. 8:129222018. View Article : Google Scholar : PubMed/NCBI

17 

Martin-Pardillos A and Cajal SRY: Characterization of Kelch domain-containing protein 7B in breast tumours and breast cancer cell lines. Oncol Lett. 18:2853–2860. 2019.PubMed/NCBI

18 

Beltrán-Anaya FO, Romero-Córdoba S, Rebollar-Vega R, Arrieta O, Bautista-Piña V, Dominguez-Reyes C, Villegas-Carlos F, Tenorio-Torres A, Alfaro-Riuz L, Jiménez-Morales S, et al: Expression of long non-coding RNA ENSG00000226738 (LncKLHDC7B) is enriched in the immunomodulatory triple-negative breast cancer subtype and its alteration promotes cell migration, invasion, and resistance to cell death. Mol Oncol. 13:909–927. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Guo P, Wang D, Wu J, Yang J, Ren T, Zhu B and Xiang Y: The landscape of alternative splicing in cervical squamous cell carcinoma. Onco Targets Ther. 8:73–79. 2015.PubMed/NCBI

20 

Wu X, Zheng X, Cheng J, Zhang K and Ma C: LncRNA TUG1 regulates proliferation and apoptosis by regulating miR-148b/IGF2 axis in ox-LDL-stimulated VSMC and HUVEC. Life Sci. 243:1172872020. View Article : Google Scholar : PubMed/NCBI

21 

Kuhn RM, Haussler D and Kent WJ: The UCSC genome browser and associated tools. Brief Bioinform. 14:144–161. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mishra GP, Ghosh A, Jha A and Raghav SK: BedSect: An integrated web server application to perform intersection, visualization, and functional annotation of genomic regions from multiple datasets. Front Genet. 11:32020. View Article : Google Scholar : PubMed/NCBI

23 

Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, et al: The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer. Mol Cancer. 17:112018. View Article : Google Scholar : PubMed/NCBI

24 

Li Z, Zhao Z, Cai Z, Sun Y, Li L, Yao F, Yang L, Zhou Y, Zhu H, Fu Y, et al: Runx2 (Runt-related transcription factor 2)-mediated microcalcification is a novel pathological characteristic and potential mediator of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 40:1352–1369. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Tian S, Zhang L, Li Y, Cao D, Quan S, Guo Y, Yang X and Yang T: Human papillomavirus E7 oncoprotein promotes proliferation and migration through the transcription factor E2F1 in cervical cancer cells. Anticancer Agents Med Chem. Nov 5–2020.(Epub ahead of print). View Article : Google Scholar

26 

Santegoets LA, Seters M, Helmerhorst TJ, Heijmans-Antonissen C, Hanifi-Moghaddam P, Ewing PC, van Ijcken WF, van der Spek PJ, van der Meijden WI and Blok LJ: HPV related VIN: Highly proliferative and diminished responsiveness to extracellular signals. Int J Cancer. 121:759–766. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Integrated genomic and molecular characterization of cervical cancer. Nature. 543:378–384. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Mao Y, Dong L, Zheng Y, Dong J and Li X: Prediction of Recurrence in Cervical Cancer Using a Nine-lncRNA Signature. Front Genet. 10:2842019. View Article : Google Scholar : PubMed/NCBI

29 

Hosseini ES, Meryet-Figuiere M, Sabzalipoor H, Kashani HH, Nikzad H and Asemi Z: Dysregulated expression of long noncoding RNAs in gynecologic cancers. Mol Cancer. 16:1072017. View Article : Google Scholar : PubMed/NCBI

30 

Feng S, Liu W, Bai X, Pan W, Jia Z, Zhang S, Zhu Y and Tan W: LncRNA-CTS promotes metastasis and epithelial-to-mesenchymal transition through regulating miR-505/ZEB2 axis in cervical cancer. Cancer Lett. 465:105–117. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Ding X, Jia X, Wang C, Xu J, Gao SJ and Lu C: A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer. Cell Death Differ. 26:1750–1765. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Wu X, Xiao Y, Yan W, Ji Z and Zheng G: The human oncogene SCL/TAL1 interrupting locus (STIL) promotes tumor growth through MAPK/ERK, PI3K/Akt and AMPK pathways in prostate cancer. Gene. 686:220–227. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Zhang G, Fan E, Yue G, Zhong Q, Shuai Y, Wu M, Feng G, Chen Q and Gou X: Five genes as a novel signature for predicting the prognosis of patients with laryngeal cancer. J Cell Biochem. Oct 31–2019.(Epub ahead of print).

34 

Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML and Pyeon D: Human papillomavirus 16 E7 stabilizes APOBEC3A protein by inhibiting cullin 2-dependent protein degradation. J Virol. 92:e01318–17. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Panayiotou T, Michael S, Zaravinos A, Demirag E, Achilleos C and Strati K: Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers. PLoS Pathog. 16:e10084682020. View Article : Google Scholar : PubMed/NCBI

36 

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, et al: Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell. 22:209–221. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, et al: The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med. 210:1545–1557. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Ngoc PCT, Tan SH, Tan TK, Chan MM, Li Z, Yeoh AEJ, Tenen DG and Sanda T: Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia. Leukemia. 32:2138–2151. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Vasseur D, Lopez J, Croce S, Tondeur G, Bonin L, Descotes F, Golfier F and Devouassoux-Shisheboran M: Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression. Gynecol Oncol. 157:775–782. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Xiang F, Liu X, Ma X, Cai X, Yang Y, Shen X, Yuan C, Xiang Y, Xiao H, Xiao H, et al: HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis. Oncol Rep 45: 51, 2021.
APA
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y. ... Xiao, H. (2021). HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis. Oncology Reports, 45, 51. https://doi.org/10.3892/or.2021.8002
MLA
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y., Shen, X., Yuan, C., Xiang, Y., Xiao, H."HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis". Oncology Reports 45.5 (2021): 51.
Chicago
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y., Shen, X., Yuan, C., Xiang, Y., Xiao, H."HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis". Oncology Reports 45, no. 5 (2021): 51. https://doi.org/10.3892/or.2021.8002
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Xiang F, Liu X, Ma X, Cai X, Yang Y, Shen X, Yuan C, Xiang Y, Xiao H, Xiao H, et al: HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis. Oncol Rep 45: 51, 2021.
APA
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y. ... Xiao, H. (2021). HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis. Oncology Reports, 45, 51. https://doi.org/10.3892/or.2021.8002
MLA
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y., Shen, X., Yuan, C., Xiang, Y., Xiao, H."HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis". Oncology Reports 45.5 (2021): 51.
Chicago
Wang, J., Xiang, F., Liu, X., Ma, X., Cai, X., Yang, Y., Shen, X., Yuan, C., Xiang, Y., Xiao, H."HPV E7 affects the function of cervical cancer cells via the TAL1/lnc‑EBIC/KLHDC7B axis". Oncology Reports 45, no. 5 (2021): 51. https://doi.org/10.3892/or.2021.8002
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