Open Access

Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review)

  • Authors:
    • Handong Huang
    • Lu Li
    • Kunming Wen
  • View Affiliations

  • Published online on: October 20, 2021     https://doi.org/10.3892/or.2021.8207
  • Article Number: 256
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Long non‑coding RNAs (lncRNAs) fulfill important roles in the majority of cellular processes. Previous studies have demonstrated that lncRNAs are involved in the pathogenesis of various diseases, including cancer. However, to date, the functions of only a small number of the known lncRNAs have been well‑documented. lncRNAs comprise a class of multifunctional non‑coding transcripts that are able to interact with different types of biomolecules. Interactions between lncRNAs and RNA‑binding proteins (RBPs) provide an important mechanism through which lncRNAs exert their regulatory functions, mainly through findings on ‘generalized RBPs’. Regulatory effects on lncRNAs mediated by RBPs have also been explored. Taking account of the research that has been completed to date, the continued and in‑depth study of the bidirectional interactions between lncRNAs and RBPs will prove to be of major importance for understanding the pathogenesis of cancer and for developing effective therapies. The present review aims to explore the interactions between lncRNAs and RBPs that have been investigated in cancer, taking into consideration several different aspects, including the regulation of expression, subcellular localization and the mediation of diverse functions.
View Figures
View References

Related Articles

Journal Cover

December-2021
Volume 46 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang H, Li L and Wen K: Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review). Oncol Rep 46: 256, 2021.
APA
Huang, H., Li, L., & Wen, K. (2021). Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review). Oncology Reports, 46, 256. https://doi.org/10.3892/or.2021.8207
MLA
Huang, H., Li, L., Wen, K."Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review)". Oncology Reports 46.6 (2021): 256.
Chicago
Huang, H., Li, L., Wen, K."Interactions between long non‑coding RNAs and RNA‑binding proteins in cancer (Review)". Oncology Reports 46, no. 6 (2021): 256. https://doi.org/10.3892/or.2021.8207