Function and transcriptional regulation of TCTN1 in oral squamous cell carcinoma

Bai,Guangliang; Wei,Ning; Li,Fang; Zhao,Peng; Meng,Zhen; Zou,Bo; Liu,Yujiao; Xu,Kai; Li,Keyi; Yao,Chao; Yang,Peng

doi:10.3892/or.2021.8237

Function and transcriptional regulation of TCTN1 in oral squamous cell carcinoma

Authors:
- Guangliang Bai
- Ning Wei
- Fang Li
- Peng Zhao
- Zhen Meng
- Bo Zou
- Yujiao Liu
- Kai Xu
- Keyi Li
- Chao Yao
- Peng Yang
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Affiliations: Department of Stomatology and Key Laboratory of Precision Biomedicine (Liaocheng), Liaocheng People's Hospital, Medical College of Liaocheng University, Liaocheng, Shandong 252000, P.R. China, Clinical Laboratory, Heze Municipal Hospital, Heze, Shandong 274000, P.R. China, Department of Oral and Maxillofacial Surgery, Jinan Stomatological Hospital, Jinan, Shandong 250000, P.R. China
Published online on: December 1, 2021 https://doi.org/10.3892/or.2021.8237
Article Number: 26
Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck squamous cell carcinoma (HNSCC) with a poor survival rate. In the present study, the involvement of tectonic 1 (TCTN1) in OSCC was explored. The relevance between TCTN1 and HNSCC clinicopathological features was first analyzed and it was revealed that TCTN1 was associated with the tumor clinical stage and grade. In in vitro experiments, it was demonstrated that the proliferative, migratory and invasive capacity of OSCC CAL27 cells and SCC15 cells was significantly suppressed due to TCTN1 knockdown. Additionally, the core promoter of TCTN1 was confirmed and transcription factor AP‑2 alpha (TFAP2A) was suggested as a regulator of TCTN1 mRNA expression. On the whole, the present study elucidated the direct association between TCTN1 and OSCC for the first time, to the best of our knowledge, and the TFAP2A/TCTN1 axis was suggested as a potential novel therapeutic target for OSCC.

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