Open Access

Regulatory functions of miR‑200b‑3p in tumor development (Review)

  • Authors:
    • Sheng Chen
    • Yifeng Tu
    • Hang Yuan
    • Zhan Shi
    • Yang Guo
    • Wenjing Gong
    • Shiliang Tu
  • View Affiliations

  • Published online on: March 23, 2022     https://doi.org/10.3892/or.2022.8307
  • Article Number: 96
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs/miRs), non‑coding single‑stranded RNAs of length 18‑24 nucleotides, can modulate gene expression through post‑transcriptional control. As such, they can influence tumor proliferation, apoptosis, invasion, metastasis as well as chemotherapy resistance by regulating certain downstream genes. In this context, miR‑200b‑3p, one particular member of the miR‑200 family, possesses the ability to suppress tumor progression. However, many studies have suggested that, in certain cases, this miRNA may also promote the development of some tumors due to differences in the microenvironments and molecular backgrounds of different cancers. This review summarizes previous studies on the involvement of miR‑200b‑3p in tumors, including the underlying mechanism.
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May-2022
Volume 47 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen S, Tu Y, Yuan H, Shi Z, Guo Y, Gong W and Tu S: Regulatory functions of miR‑200b‑3p in tumor development (Review). Oncol Rep 47: 96, 2022.
APA
Chen, S., Tu, Y., Yuan, H., Shi, Z., Guo, Y., Gong, W., & Tu, S. (2022). Regulatory functions of miR‑200b‑3p in tumor development (Review). Oncology Reports, 47, 96. https://doi.org/10.3892/or.2022.8307
MLA
Chen, S., Tu, Y., Yuan, H., Shi, Z., Guo, Y., Gong, W., Tu, S."Regulatory functions of miR‑200b‑3p in tumor development (Review)". Oncology Reports 47.5 (2022): 96.
Chicago
Chen, S., Tu, Y., Yuan, H., Shi, Z., Guo, Y., Gong, W., Tu, S."Regulatory functions of miR‑200b‑3p in tumor development (Review)". Oncology Reports 47, no. 5 (2022): 96. https://doi.org/10.3892/or.2022.8307