Open Access

Research progress of anti-glioma chemotherapeutic drugs (Review)

  • Authors:
    • Yi-Shu Zhou
    • Wei Wang
    • Na Chen
    • Li-Cui Wang
    • Jin-Bai Huang
  • View Affiliations

  • Published online on: March 30, 2022     https://doi.org/10.3892/or.2022.8312
  • Article Number: 101
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common primary intracranial malignancy in the central nervous system. At present, the most important treatment option is surgical resection of the tumor combined with radiotherapy and chemotherapy. The principle of operation is to remove the tumor to the maximal extent on the basis of preserving brain function. However, prominent invasive and infiltrative proliferation of glioma tumor cells into the surrounding normal tissues frequently reduces the efficacy of treatment. This in turn worsens the prognosis, because the tumor cannot be completely removed, which can readily relapse. Chemotherapeutic agents when applied individually have demonstrated limited efficacy for the treatment of glioma. However, multiple different chemotherapeutic agents can be used in combination with other treatment modalities to improve the efficacy while circumventing systemic toxicity and drug resistance. Therefore, it is pivotal to unravel the inhibitory mechanism mediated by the different chemotherapeutic drugs on glioma cells in preclinical studies. The aim of the present review is to provide a summary for understanding the effects of different chemotherapeutic drugs in glioma, in addition to providing a reference for the preclinical research into novel chemotherapeutic agents for future clinical application.
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May-2022
Volume 47 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou Y, Wang W, Chen N, Wang L and Huang J: Research progress of anti-glioma chemotherapeutic drugs (Review). Oncol Rep 47: 101, 2022.
APA
Zhou, Y., Wang, W., Chen, N., Wang, L., & Huang, J. (2022). Research progress of anti-glioma chemotherapeutic drugs (Review). Oncology Reports, 47, 101. https://doi.org/10.3892/or.2022.8312
MLA
Zhou, Y., Wang, W., Chen, N., Wang, L., Huang, J."Research progress of anti-glioma chemotherapeutic drugs (Review)". Oncology Reports 47.5 (2022): 101.
Chicago
Zhou, Y., Wang, W., Chen, N., Wang, L., Huang, J."Research progress of anti-glioma chemotherapeutic drugs (Review)". Oncology Reports 47, no. 5 (2022): 101. https://doi.org/10.3892/or.2022.8312