Open Access

Research progress on the therapeutic effect and mechanism of metformin for lung cancer (Review)

  • Authors:
    • Pengkai Han
    • Junhao Zhou
    • Jianhua Xiang
    • Qiping Liu
    • Kai Sun
  • View Affiliations

  • Published online on: November 7, 2022     https://doi.org/10.3892/or.2022.8440
  • Article Number: 3
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is the most common type of cancer and the leading cause of cancer‑associated death worldwide. Despite the availability of various treatments such as surgery, chemoradiotherapy, targeted drugs and immunotherapy, treatment is expensive and the prognosis remains poor. At present, lung cancer drugs and treatment programs remain in a state of continuous exploration and research to improve the prognosis, and to reduce the pain and economic burden for the patients. Type 2 diabetes is a common chronic disease in middle‑aged and elderly patients, leading to significantly increased complications of cardiovascular and cerebrovascular diseases. Epidemiology shows that type 2 diabetes also increases the incidence of malignant tumors, including lung, liver, colorectal and pancreatic cancer. Metformin is a biguanide, widely used as a first‑line oral drug in treating type 2 diabetes. Metformin has a hypoglycemic effect and a biological antitumor impact, reducing the incidence of various tumors, including lung cancer, and improving the prognosis of patients with tumors. The anti‑lung cancer effect of metformin involves a variety of mechanisms that can improve the therapeutic effect and prognosis of lung cancer, as a single drug or in combination with other therapies. The present study aims to review the associated literature and the therapeutic effects of metformin on lung cancer.
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January-2023
Volume 49 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Han P, Zhou J, Xiang J, Liu Q and Sun K: Research progress on the therapeutic effect and mechanism of metformin for lung cancer (Review). Oncol Rep 49: 3, 2023.
APA
Han, P., Zhou, J., Xiang, J., Liu, Q., & Sun, K. (2023). Research progress on the therapeutic effect and mechanism of metformin for lung cancer (Review). Oncology Reports, 49, 3. https://doi.org/10.3892/or.2022.8440
MLA
Han, P., Zhou, J., Xiang, J., Liu, Q., Sun, K."Research progress on the therapeutic effect and mechanism of metformin for lung cancer (Review)". Oncology Reports 49.1 (2023): 3.
Chicago
Han, P., Zhou, J., Xiang, J., Liu, Q., Sun, K."Research progress on the therapeutic effect and mechanism of metformin for lung cancer (Review)". Oncology Reports 49, no. 1 (2023): 3. https://doi.org/10.3892/or.2022.8440