Open Access

Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)

  • Authors:
    • Xiangxiang Lei
    • Xiaoge Hu
    • Qiliang Lu
    • Wen Fu
    • Wen Sun
    • Qiancheng Ma
    • Dongsheng Huang
    • Qiuran Xu
  • View Affiliations

  • Published online on: February 13, 2023     https://doi.org/10.3892/or.2023.8500
  • Article Number: 63
  • Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Digestive system cancers are the leading cause of cancer‑related death worldwide due to their high morbidity and mortality rates. The current treatment methods include surgical treatment, chemotherapy, radiotherapy and endoscopic treatment, and the precisely targeted therapy of digestive system cancers requires to be further studied. The ubiquitin‑proteasome system is the main pathway for protein degradation in cells and the ubiquitin‑conjugating enzymes (E2s) have a decisive role in the specific selection of target proteins for degradation. The E2s have an important physiological role in digestive system cancers, which is related to the clinical tumor stage, differentiation degree and poor prognosis. Furthermore, they are involved in the physiological processes of digestive system tumor cell proliferation, migration, invasion, stemness, drug resistance and autophagy. In the present article, the progress and achievements of the E2s in gastric cancer, hepatocellular carcinoma, pancreatic cancer, colorectal cancer, intrahepatic cholangiocarcinoma, gallbladder cancer and esophageal squamous cell carcinoma were reviewed, which may provide early screening indicators and reliable therapeutic targets for digestive system cancers.
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March-2023
Volume 49 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Lei X, Hu X, Lu Q, Fu W, Sun W, Ma Q, Huang D and Xu Q: Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review). Oncol Rep 49: 63, 2023.
APA
Lei, X., Hu, X., Lu, Q., Fu, W., Sun, W., Ma, Q. ... Xu, Q. (2023). Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review). Oncology Reports, 49, 63. https://doi.org/10.3892/or.2023.8500
MLA
Lei, X., Hu, X., Lu, Q., Fu, W., Sun, W., Ma, Q., Huang, D., Xu, Q."Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)". Oncology Reports 49.3 (2023): 63.
Chicago
Lei, X., Hu, X., Lu, Q., Fu, W., Sun, W., Ma, Q., Huang, D., Xu, Q."Ubiquitin‑conjugating enzymes as potential biomarkers and therapeutic targets for digestive system cancers (Review)". Oncology Reports 49, no. 3 (2023): 63. https://doi.org/10.3892/or.2023.8500