Effects of autophagy‑related gene 5 on tumor development and treatment (Review)

  • Authors:
    • Pengli Zhou
    • Zhou Zhang
    • Mingyue Liu
    • Ping Li
    • Ying Zhu
  • View Affiliations

  • Published online on: June 19, 2023     https://doi.org/10.3892/or.2023.8592
  • Article Number: 155
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Abstract

Autophagy is a fundamental cellular metabolic process, whose main role is to remove excess or damaged organelles and maintain the normal structural state of cells. Autophagy‑related gene 5 (ATG5) is one of the important genes involved in cellular autophagy, which is widely expressed in tissues and cells and connected to various signaling pathways. It is involved in the regulation of cell proliferation, invasion and migration as well as the tumor immune microenvironment, which affects the resistance to radiotherapy and chemotherapy, as well as the overall survival of tumor patients. Recently, many studies have confirmed that ATG5 plays a double‑edged sword role on tumors, as it can play not only pro‑tumor but also tumor‑suppressive roles. However, its role in tumor treatment has not been systematically summarized. Therefore, this paper provides a systematic summary of the basic functions of ATG5, its role in the development and treatment of tumors and potentially give some ideas for clinical treatment of tumors.
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August-2023
Volume 50 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou P, Zhang Z, Liu M, Li P and Zhu Y: Effects of autophagy‑related gene 5 on tumor development and treatment (Review). Oncol Rep 50: 155, 2023.
APA
Zhou, P., Zhang, Z., Liu, M., Li, P., & Zhu, Y. (2023). Effects of autophagy‑related gene 5 on tumor development and treatment (Review). Oncology Reports, 50, 155. https://doi.org/10.3892/or.2023.8592
MLA
Zhou, P., Zhang, Z., Liu, M., Li, P., Zhu, Y."Effects of autophagy‑related gene 5 on tumor development and treatment (Review)". Oncology Reports 50.2 (2023): 155.
Chicago
Zhou, P., Zhang, Z., Liu, M., Li, P., Zhu, Y."Effects of autophagy‑related gene 5 on tumor development and treatment (Review)". Oncology Reports 50, no. 2 (2023): 155. https://doi.org/10.3892/or.2023.8592