Open Access

Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review)

  • Authors:
    • Minmin Li
    • Dongyuan Sun
    • Ning Song
    • Xi Chen
    • Xinyue Zhang
    • Wentian Zheng
    • Yang Yu
    • Chengbing Han
  • View Affiliations

  • Published online on: July 11, 2023     https://doi.org/10.3892/or.2023.8599
  • Article Number: 162
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most widespread malignancies worldwide. p53, as a transcription factor, can play its role in tumor suppression by activating the expression of numerous target genes. However, p53 is one of the most commonly mutated genes, which frequently harbors missense mutations. These missense mutations are nucleotide substitutions that result in the substitution of an amino acid in the DNA binding domain. Most p53 mutations in HNSCC are missense mutations and the mutation rate of p53 reaches 65‑85%. p53 mutation not only inhibits the tumor suppressive function of p53 but also provides novel functions to facilitate tumor recurrence, called gain‑of‑function (GOF). The present study focused on the prevalence and clinical relevance of p53 mutations in HNSCC, and further described how mutant p53 accumulates. Moreover, mutant p53 in HNSCC can interact with proteins, RNA, and exosomes to exert effects on proliferation, migration, invasion, immunosuppression, and metabolism. Finally, several treatment strategies have been proposed to abolish the tumor‑promoting function of mutant p53; these strategies include reactivation of mutant p53 into wild‑type p53, induction of mutant p53 degradation, enhancement of the synthetic lethality of mutant p53, and treatment with immunotherapy. Due to the high frequency of p53 mutations in HNSCC, a further understanding of the mechanism of mutant p53 may provide potential applications for targeted therapy in patients with HNSCC.
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September-2023
Volume 50 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Li M, Sun D, Song N, Chen X, Zhang X, Zheng W, Yu Y and Han C: Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review). Oncol Rep 50: 162, 2023
APA
Li, M., Sun, D., Song, N., Chen, X., Zhang, X., Zheng, W. ... Han, C. (2023). Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review). Oncology Reports, 50, 162. https://doi.org/10.3892/or.2023.8599
MLA
Li, M., Sun, D., Song, N., Chen, X., Zhang, X., Zheng, W., Yu, Y., Han, C."Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review)". Oncology Reports 50.3 (2023): 162.
Chicago
Li, M., Sun, D., Song, N., Chen, X., Zhang, X., Zheng, W., Yu, Y., Han, C."Mutant p53 in head and neck squamous cell carcinoma: Molecular mechanism of gain‑of‑function and targeting therapy (Review)". Oncology Reports 50, no. 3 (2023): 162. https://doi.org/10.3892/or.2023.8599