Emerging histological and serological biomarkers in oral squamous cell carcinoma: Applications in diagnosis, prognosis evaluation and personalized therapeutics (Review)
- Authors:
- Leonel Pekarek
- Maria J. Garrido‑Gil
- Alicia Sánchez‑Cendra
- Javier Cassinello
- Tatiana Pekarek
- Oscar Fraile‑Martinez
- Cielo García‑Montero
- Laura Lopez‑Gonzalez
- Antonio Rios‑Parra
- Melchor Álvarez‑Mon
- Julio Acero
- Raul Diaz‑Pedrero
- Miguel A. Ortega
-
Affiliations: Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, Spain, Oncology Service, Guadalajara University Hospital, 19002 Guadalajara, Spain, Ramón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, Spain - Published online on: October 20, 2023 https://doi.org/10.3892/or.2023.8650
- Article Number: 213
-
Copyright: © Pekarek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G and Boccia S: Prognostic factors in head and neck cancer: A 10-year retrospective analysis in a single-institution in Italy. Acta Otorhinolaryngol Ital. 37:458–466. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Reyes-Gibby CC, Anderson KO, Merriman KW, Todd KH, Shete SS and Hanna EY: Survival patterns in squamous cell carcinoma of the head and neck: Pain as an independent prognostic factor for survival. J Pain. 15:1015–1022. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Barsouk A, Aluru JS, Rawla P, Saginala K and Barsouk A: Epidemiology, risk factors, and prevention of head and neck squamous cell carcinoma. Med Sci (Basel). 11:422023.PubMed/NCBI | |
|
Gormley M, Creaney G, Schache A, Ingarfield K and Conway DI: Reviewing the epidemiology of head and neck cancer: Definitions, trends and risk factors. Br Dent J. 233:780–786. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SM: Human papilloma virus in oral cancer. J Korean Assoc Oral Maxillofac Surg. 42:327–336. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Sathish N, Wang X and Yuan Y: Human papillomavirus (HPV)-associated oral cancers and treatment strategies. J Dent Res. 93 (Suppl 7):29S–36S. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Oliveira AC, Cavalcanti de Lima IC, Frez Marques VM, Alves de Araújo WH and De Campos Ferreira C: Human papillomavirus prevalence in oral and oropharyngeal squamous cell carcinoma in South America: A systematic review and meta-analysis. Oncol Rev. 16:5522022. View Article : Google Scholar : PubMed/NCBI | |
|
Petti S: Lifestyle risk factors for oral cancer. Oral Oncol. 45:340–350. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Candotto V, Lauritano D, Nardone M, Baggi L, Arcuri C, Gatto R, Gaudio RM, Spadari F and Carinci F: HPV infection in the oral cavity: Epidemiology, clinical manifestations and relationship with oral cancer. Oral Implantol (Rome). 10:209–220. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bagan J, Sarrion G and Jimenez Y: Oral cancer: Clinical features. Oral Oncol. 46:414–417. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Gileva OS, Libik TV and Danilov KV: Oral precancerous lesions: Problems of early detection and oral cancer prevention. AIP Conf Proc. 1760:0200192016. View Article : Google Scholar | |
|
Güneri P and Epstein JB: Late stage diagnosis of oral cancer: Components and possible solutions. Oral Oncol. 50:1131–1136. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Baykul T, Yilmaz HH, Aydin U, Aydin MA, Aksoy M and Yildirim D: Early diagnosis of oral cancer. J Int Med Res. 38:737–749. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
McGuirt WF: Panendoscopy as a screening examination for simultaneous primary tumors in head and neck cancer: A prospective sequential study and review of the literature. Laryngoscope. 92:569–576. 1982. View Article : Google Scholar : PubMed/NCBI | |
|
Fulciniti F, Califano L, Zupi A and Vetrani A: Accuracy of fine needle aspiration biopsy in head and neck tumors. J Oral Maxillofac Surg. 55:1094–1097. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Burkill GJC, Evans RM, Raman VV and Connor SEJ: Modern radiology in the management of head and neck cancer. Clin Oncol (R Coll Radiol). 28:440–450. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Dai YL and King AD: State of the art MRI in head and neck cancer. Clin Radiol. 73:45–59. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Irani S: Distant metastasis from oral cancer: A review and molecular biologic aspects. J Int Soc Prev Community Dent. 6:265–271. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
El-Naaj IA, Leiser Y, Shveis M, Sabo E and Peled M: Incidence of oral cancer occult metastasis and survival of T1-T2N0 oral cancer patients. J Oral Maxillofac Surg. 69:2674–2679. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zanoni DK, Patel SG and Shah JP: Changes in the 8th edition of the American joint committee on cancer (AJCC) staging of head and neck cancer: Rationale and implications. Curr Oncol Rep. 21:522019. View Article : Google Scholar : PubMed/NCBI | |
|
Shah JP and Gil Z: Current concepts in management of oral cancer-surgery. Oral Oncol. 45:394–401. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Huang SH and O'Sullivan B: Oral cancer: Current role of radiotherapy and chemotherapy. Med Oral Patol Oral Cir Bucal. 18:e233–e240. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Lang K, Baur M, Held T, Shafie RE, Moratin J, Freudlsperger C, Zaoui K, Bougatf N, Hoffmann J, Plinkert PK, et al: Definitive radiotherapy for squamous cell carcinoma of the oral cavity: A single-institution experience. Radiol Oncol. 55:467–473. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Hartner L: Chemotherapy for oral cancer. Dent Clin North Am. 62:87–97. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kimura I, Kitahara H, Ooi K, Kato K, Noguchi N, Yoshizawa K, Nakamura H and Kawashiri S: Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition. Oncol Lett. 11:201–207. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Sun S, Zeng X and Li J: ICI-based therapies: A new strategy for oral potentially malignant disorders. Oral Oncol. 140:1063882023. View Article : Google Scholar : PubMed/NCBI | |
|
Doumas S, Foukas PG, Economopoulou P, Kotsantis I and Psyrri A: Atypical patterns of responses in the era of immune checkpoint inhibitors in head and neck cancer. Oral Oncol. 100:1044772020. View Article : Google Scholar : PubMed/NCBI | |
|
Mohanty V, Subbannayya Y, Patil S, Puttamallesh VN, Najar MA, Datta KK, Pinto SM, Begum S, Mohanty N, Routray S, et al: Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue. J Cell Commun Signal. 15:447–459. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Tokuzen N, Nakashiro KI, Tojo S, Goda H, Kuribayashi N and Uchida D: Human papillomavirus-16 infection and p16 expression in oral squamous cell carcinoma. Oncol Lett. 22:5282021. View Article : Google Scholar : PubMed/NCBI | |
|
Vergori A, Garbuglia AR, Piselli P, Del Nonno F, Sias C, Lupi F, Lapa D, Baiocchini A, Cimaglia C, Gentile M, et al: Oral human papillomavirus DNA detection in HIV-positive men: Prevalence, predictors, and co-occurrence at anal site. BMC Infect Dis. 18:252018. View Article : Google Scholar : PubMed/NCBI | |
|
Sritippho T, Chotjumlong P and Iamaroon A: Roles of human papillomaviruses and p16 in oral cancer. Asian Pac J Cancer Prev. 16:6193–6200. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Castro TPPG and Bussoloti Filho I: Prevalence of human papillomavirus (HPV) in oral cavity and oropharynx. Braz J Otorhinolaryngol. 72:272–281. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Katirachi SK, Grønlund MP, Jakobsen KK, Grønhøj C and von Buchwald C: The prevalence of HPV in oral cavity squamous cell carcinoma. Viruses. 15:4512023. View Article : Google Scholar : PubMed/NCBI | |
|
Doll C, Steffen C, Beck-Broichsitter B, Richter M, Neumann K, Pohrt A, Lohneis P, Lehmann A, Heiland M, Stromberger C, et al: The prognostic significance of p16 and its role as a surrogate marker for human papilloma virus in oral squamous cell carcinoma: An analysis of 281 cases. Anticancer Res. 42:2405–2413. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Christianto S, Li KY, Huang TH and Su Y: The prognostic value of human papilloma virus infection in oral cavity squamous cell carcinoma: A meta-analysis. Laryngoscope. 132:1760–1770. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Miranda-Galvis M, Rumayor Piña A, Sales de Sá R, Almeida Leite A, Agustin Vargas P, Calsavara VF, Lópes Pinto CA, Teng Y and Kowalski LP: PD-L1 expression patterns in oral cancer as an integrated approach for further prognostic classification. Oral Dis. 27:1699–1710. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Lenouvel D, González-Moles MÁ, Ruiz-Ávila I, Chamorro-Santos C, González-Ruiz L, González-Ruiz I and Ramos-García P: Clinicopathological and prognostic significance of PD-L1 in oral cancer: A preliminary retrospective immunohistochemistry study. Oral Dis. 27:173–182. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Dave K, Ali A and Magalhaes M: Increased expression of PD-1 and PD-L1 in oral lesions progressing to oral squamous cell carcinoma: A pilot study. Sci Rep. 10:97052020. View Article : Google Scholar : PubMed/NCBI | |
|
Wu T, Tang C, Tao R, Yong X, Jiang Q and Feng C: PD-L1-mediated immunosuppression in oral squamous cell carcinoma: Relationship with macrophage infiltration and epithelial to mesenchymal transition markers. Front Immunol. 12:6938812021. View Article : Google Scholar : PubMed/NCBI | |
|
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland Å, et al: Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study. Lancet. 394:1915–1928. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ries J, Agaimy A, Wehrhan F, Baran C, Bolze S, Danzer E, Frey S, Jantsch J, Möst T, Büttner-Herold M, et al: Importance of the PD-1/PD-L1 axis for malignant transformation and risk assessment of oral leukoplakia. Biomedicines. 9:1942021. View Article : Google Scholar : PubMed/NCBI | |
|
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Botticelli A, Cirillo A, Strigari L, Valentini F, Cerbelli B, Scagnoli S, Cerbelli E, Zizzari IG, Rocca CD, D'Amati G, et al: Anti-PD-1 and anti-PD-L1 in head and neck cancer: A network meta-analysis. Front Immunol. 12:7050962021. View Article : Google Scholar : PubMed/NCBI | |
|
Fasano M, Corte CMD, Liello RD, Viscardi G, Sparano F, Iacovino ML, Paragliola F, Piccolo A, Napolitano S, Martini G, et al: Immunotherapy for head and neck cancer: Present and future. Crit Rev Oncol Hematol. 174:1036792022. View Article : Google Scholar : PubMed/NCBI | |
|
Wongpattaraworakul W, Gibson-Corley KN, Choi A, Buchakjian MR, Lanzel EA, Rajan Kd A and Simons AL: Prognostic role of combined EGFR and tumor-infiltrating lymphocytes in oral squamous cell carcinoma. Front Oncol. 12:8852362022. View Article : Google Scholar : PubMed/NCBI | |
|
Chen IH, Chang JT, Liao CT, Wang HM, Hsieh LL and Cheng AJ: Prognostic significance of EGFR and Her-2 in oral cavity cancer in betel quid prevalent area cancer prognosis. Br J Cancer. 89:681–686. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Kang JJ, Ko A, Kil SH, Mallen-St Clair J, Shin DS, Wang MB and Srivatsan ES: EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy. Biochim Biophys Acta Rev Cancer. 1878:1888272023. View Article : Google Scholar : PubMed/NCBI | |
|
Bossi P, Resteghini C, Paielli N, Licitra L, Pilotti S and Perrone F: Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma. Oncotarget. 7:74362–74379. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Moharil R, Khandekar S, Dive A and Bodhade A: Cyclin D1 in oral premalignant lesions and oral squamous cell carcinoma: An immunohistochemical study. J Oral Maxillofac Pathol. 24:3972020. View Article : Google Scholar : PubMed/NCBI | |
|
Lam KY, Ng IO, Yuen AP, Kwong DL and Wei W: Cyclin D1 expression in oral squamous cell carcinomas: Clinicopathological relevance and correlation with p53 expression. J Oral Pathol Med. 29:167–172. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Ahmed MAS, Omer N, Suliman AM and Ellaithi M: Expression of cyclin D1 in oral squamous cell carcinoma. Sudan J Med Sci. 16:558–566. 2021. | |
|
Saawarn S, Astekar M, Saawarn N, Dhakar N and Gomateshwar Sagari S: Cyclin D1 expression and its correlation with histopathological differentiation in oral squamous cell carcinoma. ScientificWorldJournal. 2012:9783272012. View Article : Google Scholar : PubMed/NCBI | |
|
Acero-Mondragón E, Rodríguez-Farías R, Salazar-Hernández M and Figueroa-Avendaño J: Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity. Rev Odontol Mex. 20:e225–e229. 2016. View Article : Google Scholar | |
|
Ramos-García P, González-Moles MÁ, González-Ruiz L, Ayén Á, Ruiz-Ávila I, Bravo M and Gil-Montoya JA: Clinicopathological significance of tumor cyclin D1 expression in oral cancer. Arch Oral Biol. 99:177–182. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Huang SF, Cheng SD, Chuang WY, Chen IH, Liao CT, Wang HM and Hsieh LL: Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma. World J Surg Oncol. 10:402012. View Article : Google Scholar : PubMed/NCBI | |
|
Awawdeh MA, Sasikumar R, Aboalela AA, Siddeeqh S, Gopinathan PA, Sawair F and Khanagar SB: Evaluation of prognostic significance of the expression of p53, cyclin D1, EGFR in advanced oral squamous cell carcinoma after chemoradiation-A systematic review. Appl Sci. 13:52922023. View Article : Google Scholar | |
|
Takkem A, Barakat C, Zakarea S, Zaid K, Najmeh J, Ayoub M and Seirawan MY: Ki-67 prognostic value in different histological grades of oral epithelial dysplasia and oral squamous cell carcinoma. Asian Pac J Cancer Prev. 19:3279–3286. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Davey MG, Hynes SO, Kerin MJ, Miller N and Lowery AJ: Ki-67 as a prognostic biomarker in invasive breast cancer. Cancers (Basel). 13:44552021. View Article : Google Scholar : PubMed/NCBI | |
|
Li LT, Jiang G, Chen Q and Zheng JN: Ki67 is a promising molecular target in the diagnosis of cancer (review). Mol Med Rep. 11:1566–1572. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Xie S, Liu Y, Qiao X, Hua RX, Wang K, Shan XF and Cai ZG: What is the prognostic significance of Ki-67 positivity in oral squamous cell carcinoma? J Cancer. 7:758–767. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Meyer HJ, Gundermann P and Surov A: Associations between FDG-PET and Ki 67-index in head and neck cancer: A meta-analysis. Medicine (Baltimore). 98:e174722019. View Article : Google Scholar : PubMed/NCBI | |
|
Lopes VKM, de Jesus AS, de Souza LL, Miyahara LAN, Guimarães DM, Pontes HAR, Pontes FSC and Carvalho PL: Ki-67 protein predicts survival in oral squamous carcinoma cells: An immunohistochemical study. Braz Oral Res. 31:e662017. View Article : Google Scholar : PubMed/NCBI | |
|
Mohamed AA, EL-Shall OS and EL-Kilani NS: Role of expression Ki-67 in diagnosis of oral cancer. Al-Azhar Dent J Girls. 7:441–445. 2020. View Article : Google Scholar | |
|
Govindaraj PK, Kallarakkal TG, Mohd Zain R, Tilakaratne WM and Lew HL: Expression of Ki-67, Cornulin and ISG15 in non-involved mucosal surgical margins as predictive markers for relapse in oral squamous cell carcinoma (OSCC). PLoS One. 16:e02615752021. View Article : Google Scholar : PubMed/NCBI | |
|
Pan W, Zhang C, Chen M, Min S, Xu L and Chi Z: Expression of Ki-67 and P16 are related with HPV in squamous cell carcinoma of the external auditory canal. J Otolaryngol Head Neck Surg. 51:402022. View Article : Google Scholar : PubMed/NCBI | |
|
Jun W, Shaobo O, Xianhua Z, Siyu Z, Mingyang C, Xin F, Ying C and Lan L: Deregulation of hsa_circ_0001971/miR-186 and hsa_circ_0001874/miR-296 signaling pathways promotes the proliferation of oral squamous carcinoma cells by synergistically activating SHP2/PLK1 signals. Sci Rep. 11:205612021. View Article : Google Scholar : PubMed/NCBI | |
|
Murase R, Abe Y, Takeuchi T, Nabeta M, Imai Y, Kamei Y, Kagawa-Miki L, Ueda N, Sumida T, Hamakawa H and Kito K: Serum autoantibody to sideroflexin 3 as a novel tumor marker for oral squamous cell carcinoma. Proteomics Clin Appl. 2:517–527. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Mauro C, Passerini R, Spaggiari L, Galetta D, Radice D, Lentati P and Sandri MT: New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1. Int J Biol Markers. 34:163–167. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Deepa T and Thirrunavukkarasu N: Saliva as a potential diagnostic tool. Indian J Med Sci. 64:293–306. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Johnstone S and Logan RM: The role of vascular endothelial growth factor (VEGF) in oral dysplasia and oral squamous cell carcinoma. Oral Oncol. 42:337–342. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Edirisinghe ST, Weerasekera M, De Silva DK, Devmini MT, Pathmaperuma S, Wijesinghe GK, Nisansala T, Maddumage A, Huzaini H, Rich AM, et al: Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR-2) as potential biomarkers for oral squamous cell carcinoma: A Sri Lankan study. Asian Pac J Cancer Prev. 24:267–274. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Kim SK, Park SG and Kim KW: Expression of vascular endothelial growth factor in oral squamous cell carcinoma. J Korean Assoc Oral Maxillofac Surg. 41:11–18. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP and Looi CY: The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: Signaling, therapeutic implications, and challenges. Cells. 8:11182019. View Article : Google Scholar : PubMed/NCBI | |
|
Alsafadi R and Manadili A: The correlation between CD44 and angiogenesis in oral squamous cell carcinoma induced in buccal pouch in syrian hamster that underwent radiotherapy. Asian Pac J Cancer Prev. 23:3571–3576. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang CZ, Cheng XQ, Li JY, Zhang P, Yi P, Xu X and Zhou XD: Saliva in the diagnosis of diseases. Int J Oral Sci. 8:133–137. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Roi A, Rusu LC, Roi CI, Luca RE, Boia S and Munteanu RI: A new approach for the diagnosis of systemic and oral diseases based on salivary biomolecules. Dis Markers. 2019:87618602019. View Article : Google Scholar : PubMed/NCBI | |
|
Goldoni R, Scolaro A, Boccalari E, Dolci C, Scarano A, Inchingolo F, Ravazzani P, Muti P and Tartaglia G: Malignancies and biosensors: A focus on oral cancer detection through salivary biomarkers. Biosensors (Basel). 11:3962021. View Article : Google Scholar : PubMed/NCBI | |
|
Konings H, Stappers S, Geens M, De Winter BY, Lamote K, van Meerbeeck JP, Specenier P, Vanderveken OM and Ledeganck KJ: A literature review of the potential diagnostic biomarkers of head and neck neoplasms. Front Oncol. 10:10202020. View Article : Google Scholar : PubMed/NCBI | |
|
Rajkumar K, Ramya R, Nandhini G, Rajashree P, Ramesh Kumar A and Nirmala Anandan S: Salivary and serum level of CYFRA 21-1 in oral precancer and oral squamous cell carcinoma. Oral Dis. 21:90–96. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Liu L, Xie W, Xue P, Wei Z, Liang X and Chen N: Diagnostic accuracy and prognostic applications of CYFRA 21-1 in head and neck cancer: A systematic review and meta-analysis. PLoS One. 14:e02165612019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Cao Y, He S and Cai W: Technical and clinical performance of two methods to detect squamous cell carcinoma antigen levels for comparing pathological diagnosis coincidence rates in lung, cervical, and head and neck cancers. Clin Lab. 66:2020. View Article : Google Scholar | |
|
Yasumatsu R, Nakano T, Hashimoto K, Kogo R, Wakasaki T and Nakagawa T: The clinical value of serum squamous cell carcinoma antigens 1 and 2 in head and neck squamous cell carcinoma. Auris Nasus Larynx. 46:135–140. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Obata K, Yutori H, Yoshida K, Sakamoto Y, Ono K and Ibaragi S: Relationships between squamous cell carcinoma antigen and cytokeratin 19 fragment values and renal function in oral cancer patients. Int J Oral Maxillofac Surg. 52:417–422. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Lin D, Shen L, Luo M, Zhang K, Li J, Yang Q, Zhu F, Zhou D, Zheng S, Chen Y and Zhou J: Circulating tumor cells: Biology and clinical significance. Signal Transduct Target Ther. 6:4042021. View Article : Google Scholar : PubMed/NCBI | |
|
Deng Z, Wu S, Wang Y and Shi D: Circulating tumor cell isolation for cancer diagnosis and prognosis. EBioMedicine. 83:1042372022. View Article : Google Scholar : PubMed/NCBI | |
|
Kulasinghe A, Hughes BGM, Kenny L and Punyadeera C: An update: Circulating tumor cells in head and neck cancer. Expert Rev Mol Diagn. 19:1109–1115. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Perumal V, Corica T, Dharmarajan A, Sun Z, Dhaliwal SS, Dass CR and Dass J: Circulating tumour cells (CTC), head and neck cancer and radiotherapy; future perspectives. Cancers (Basel). 11:3672019. View Article : Google Scholar : PubMed/NCBI | |
|
Liskova A, Samec M, Koklesova L, Giordano FA, Kubatka P and Golubnitschaja O: Liquid biopsy is instrumental for 3PM dimensional solutions in cancer management. J Clin Med. 9:27492020. View Article : Google Scholar : PubMed/NCBI | |
|
Anjum A, Shree R.VB, Jayaram Thambiah L and Rodrigues C: A comparitive and prognostic study of circulating tumor cells and vegfr-2 in different histological grades of oral squamous cell carcinoma. Int J Adv Res. 10:745–754. 2022. View Article : Google Scholar | |
|
Qayyumi B, Bharde A, Aland G, D'Souza A, Jayant S, Singh N, Tripathi S, Badave R, Kale N, Singh B, et al: Circulating tumor cells as a predictor for poor prognostic factors and overall survival in treatment naïve oral squamous cell carcinoma patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 134:73–83. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Gauthier A, Philouze P, Lauret A, Alphonse G, Malesys C, Ardail D, Payen L, Céruse P, Wozny AS and Rodriguez-Lafrasse C: Circulating tumor cell detection during neoadjuvant chemotherapy to predict early response in locally advanced oropharyngeal cancers: A prospective pilot study. J Pers Med. 12:4452022. View Article : Google Scholar : PubMed/NCBI | |
|
Curtin J, Thomson P, Wong G, Lam A and Choi SW: The impact of surgery on circulating malignant tumour cells in oral squamous cell carcinoma. Cancers (Basel). 15:5842023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Ekanayake Weeramange C, Hughes BGM, Vasani S, Liu ZY, Warkiani ME, Hartel G, Ladwa R, Thiery JP, Kenny L and Punyadeera C: Application of circulating tumour cells to predict response to treatment in head and neck cancer. Cell Oncol (Dordr). 45:543–555. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Sahibzada HA, Khurshid Z, Khan RS, Naseem M, Siddique KM, Mali M and Zafar MS: Salivary IL-8, IL-6 and TNF-α as potential diagnostic biomarkers for oral cancer. Diagnostics (Basel). 7:212017. View Article : Google Scholar : PubMed/NCBI | |
|
Khurshid Z, Zafar MS, Khan RS, Najeeb S, Slowey PD and Rehman IU: Role of salivary biomarkers in oral cancer detection. Advances in Clinical Chemistry. Vol. 86. Elsevier; pp. pp23–70. 2018, http://dx.doi.org/10.1016/bs.acc.2018.05.002 View Article : Google Scholar : PubMed/NCBI | |
|
Khurshid Z, Warsi I, Moin SF, Slowe PD, Latif M, Zohaib S and Zafar MS: Biochemical analysis of oral fluids for disease detection. Advances in Clinical Chemistry. Vol. 100. Elsevier; pp. pp205–253. 2021, http://dx.doi.org/10.1016/bs.acc.2020.04.005 View Article : Google Scholar : PubMed/NCBI | |
|
Chu HW, Chang KP, Hsu CW, Chang IY, Liu HP, Chen YT and Wu CC: Identification of salivary biomarkers for oral cancer detection with untargeted and targeted quantitative proteomics approaches. Mol Cell Proteomics. 18:1796–1806. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chiamulera MMA, Zancan CB, Remor AP, Cordeiro MF, Gleber-Netto FO and Baptistella AR: Salivary cytokines as biomarkers of oral cancer: A systematic review and meta-analysis. BMC Cancer. 21:2052021. View Article : Google Scholar : PubMed/NCBI | |
|
St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, et al: Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 130:929–935. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng YSL, Rees T and Wright J: A review of research on salivary biomarkers for oral cancer detection. Clin Transl Med. 3:32014. View Article : Google Scholar : PubMed/NCBI |
