Open Access

Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)

  • Authors:
    • Yuxuan Shi
    • Xiangyi Lin
    • Jinwen Wang
    • Zhiqing Zhou
    • Sijie Chen
    • Guoan Chen
  • View Affiliations

  • Published online on: February 15, 2024     https://doi.org/10.3892/or.2024.8714
  • Article Number: 55
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is now widely accepted that there is a specific metabolic pattern in tumor cells termed the Warburg effect, which causes tumor cells to tend to use glycolysis for energy. Hypoxia‑inducible factor (HIF) 1α is involved in these metabolic patterns as a key molecule promoting glycolysis. In addition, there is now increasing evidence that targeting this metabolic pattern of the tumor to cut off the energy source of the tumor tissue is an effective therapeutic modality. However, different molecules are involved in the regulation of the HIF‑1α/glycolysis axis in different tumor tissues. This review focused on non‑small cell lung cancer (NSCLC) to elucidate the currently known signaling pathways centered on the HIF‑1α/glycolysis axis and to identify the key molecules that can serve as therapeutic targets. It also summarized the effective methods of treatment of NSCLC by inhibition of HIF‑1α/glycolysis that have emerged in recent years.
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April-2024
Volume 51 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Shi Y, Lin X, Wang J, Zhou Z, Chen S and Chen G: Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncol Rep 51: 55, 2024
APA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., & Chen, G. (2024). Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review). Oncology Reports, 51, 55. https://doi.org/10.3892/or.2024.8714
MLA
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51.4 (2024): 55.
Chicago
Shi, Y., Lin, X., Wang, J., Zhou, Z., Chen, S., Chen, G."Advances of HIF‑1α/glycolysis axis in non‑small cell lung cancer (Review)". Oncology Reports 51, no. 4 (2024): 55. https://doi.org/10.3892/or.2024.8714