Open Access

Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)

  • Authors:
    • Qiongqing Huang
    • Zhengui Liang
    • Qiqi Huang
    • Xueyu Li
    • Jingjing Xia
    • Lining Huang
    • Lin Bing Huang
    • Chao Ou
  • View Affiliations

  • Published online on: April 25, 2024     https://doi.org/10.3892/or.2024.8743
  • Article Number: 84
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Even under aerobic conditions, tumor cells can reprogram their metabolism to preferentially metabolize glucose into lactic acid. This abnormal metabolic pattern, known as the ‘Warburg’ effect or aerobic glycolysis, promotes cancer progression. Long non‑coding RNAs (lncRNAs) are RNAs that are >200 nucleotides in length and do not have protein‑coding capabilities. However, these RNAs play a key role in tumor development. There is increasing evidence to indicate that lncRNAs regulate glucose metabolism in tumor cells by affecting metabolic enzymes and some signaling pathways, thereby regulating the occurrence and progression of hepatocellular carcinoma (HCC). Therefore, it is crucial to understand which lncRNAs play a regulatory role in HCC glycolysis and to determine the related molecular mechanisms. The present review summarized and discussed the functions of lncRNAs, focusing on the regulatory mechanisms of lncRNAs in the process of glycolysis in HCC. In addition, the present review suggests the importance of lncRNAs as future therapeutic targets for antitumor cell metabolism.
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June-2024
Volume 51 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Huang Q, Liang Z, Huang Q, Li X, Xia J, Huang L, Huang LB and Ou C: Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review). Oncol Rep 51: 84, 2024.
APA
Huang, Q., Liang, Z., Huang, Q., Li, X., Xia, J., Huang, L. ... Ou, C. (2024). Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review). Oncology Reports, 51, 84. https://doi.org/10.3892/or.2024.8743
MLA
Huang, Q., Liang, Z., Huang, Q., Li, X., Xia, J., Huang, L., Huang, L. B., Ou, C."Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)". Oncology Reports 51.6 (2024): 84.
Chicago
Huang, Q., Liang, Z., Huang, Q., Li, X., Xia, J., Huang, L., Huang, L. B., Ou, C."Involvement of lncRNAs in the regulation of aerobic glycolysis in hepatocellular carcinoma: Main functions, regulatory mechanisms and potential therapeutic implications (Review)". Oncology Reports 51, no. 6 (2024): 84. https://doi.org/10.3892/or.2024.8743