Open Access

Unravelling the therapeutic potential of forkhead box proteins in breast cancer: An update (Review)

  • Authors:
    • Sadaf Anwar
    • Mubashir Zafar
    • Malik Asif Hussain
    • Naveed Iqbal
    • Abrar Ali
    • Sadaf
    • Simran Kaur
    • Mohammad Zeeshan Najm
    • Mohd Adnan Kausar
  • View Affiliations

  • Published online on: June 4, 2024     https://doi.org/10.3892/or.2024.8751
  • Article Number: 92
  • Copyright: © Anwar et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer, a prominent cause of mortality among women, develops from abnormal growth of breast tissue, thereby rendering it one of the most commonly detected cancers in the female population. Although numerous treatment strategies are available for breast cancer, discordance in terms of effective treatment and response still exists. Recently, the potential of signaling pathways and transcription factors has gained substantial attention in the cancer community; therefore, understanding their role will assist researchers in comprehending the onset and advancement of breast cancer. Forkhead box (FOX) proteins, which are important transcription factors, are considered crucial regulators of various cellular activities, including cell division and proliferation. The present study explored several subclasses of FOX proteins and their possible role in breast carcinogenesis, followed by the interaction between microRNA (miRNA) and FOX proteins. This interaction is implicated in promoting cell infiltration into surrounding tissues, ultimately leading to metastasis. The various roles that FOX proteins play in breast cancer development, their intricate relationships with miRNA, and their involvement in therapeutic resistance highlight the complexity of breast cancer dynamics. Therefore, recognizing the progress and challenges in current treatments is crucial because, despite advancements, persistent disparities in treatment effectiveness underscore the need for ongoing research, with future studies emphasizing the necessity for targeted strategies that account for the multifaceted aspects of breast cancer.
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July-2024
Volume 52 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Anwar S, Zafar M, Hussain MA, Iqbal N, Ali A, Sadaf , Kaur S, Najm MZ and Kausar MA: Unravelling the therapeutic potential of forkhead box proteins in breast cancer: An update (Review). Oncol Rep 52: 92, 2024.
APA
Anwar, S., Zafar, M., Hussain, M.A., Iqbal, N., Ali, A., Sadaf, ... Kausar, M.A. (2024). Unravelling the therapeutic potential of forkhead box proteins in breast cancer: An update (Review). Oncology Reports, 52, 92. https://doi.org/10.3892/or.2024.8751
MLA
Anwar, S., Zafar, M., Hussain, M. A., Iqbal, N., Ali, A., Sadaf, , Kaur, S., Najm, M. Z., Kausar, M. A."Unravelling the therapeutic potential of forkhead box proteins in breast cancer: An update (Review)". Oncology Reports 52.1 (2024): 92.
Chicago
Anwar, S., Zafar, M., Hussain, M. A., Iqbal, N., Ali, A., Sadaf, , Kaur, S., Najm, M. Z., Kausar, M. A."Unravelling the therapeutic potential of forkhead box proteins in breast cancer: An update (Review)". Oncology Reports 52, no. 1 (2024): 92. https://doi.org/10.3892/or.2024.8751