Open Access

The pathogenic response of cytotoxic T‑lymphocytes, a common therapeutic target for cancer, has a direct impact on treatment outcomes (Review)

  • Authors:
    • Jing Luan
    • Yuxin Liu
    • Meng Cao
    • Xianing Guo
    • Na Guo
  • View Affiliations

  • Published online on: June 17, 2024     https://doi.org/10.3892/or.2024.8757
  • Article Number: 98
  • Copyright: © Luan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cytotoxic T lymphocytes (CTLs), also known as CD8+ T cells, participate in immune function by secreting various cytokines after recognizing specific antigens and class I major histocompatibility complex molecules associated with tumor cells, and thus have a key role in antitumor immunity. However, certain CD8+ T cells show low reactivity and thus cannot effectively remove tumor cells or viral antigens. Due to this heterogeneity, effective biomarkers representing these differences in CD8+ cells are needed. The identification of suitable biomarkers will also enhance the management of cancer treatment. Recent research has improved the understanding of CD8+ T lymphocytes in the tumor microenvironment and circulatory system. Treatment efficacy is impacted directly by the pathogenic response of CTLs, and thus, the use of adjuvant therapies to address these pathological changes, e.g., stimulating the increase in the proportion of reactive T cells or suppressing the proportion of terminally exhausted T cells, would be advantageous.
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July-2024
Volume 52 Issue 1

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Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Luan J, Liu Y, Cao M, Guo X and Guo N: The pathogenic response of cytotoxic T‑lymphocytes, a common therapeutic target for cancer, has a direct impact on treatment outcomes (Review). Oncol Rep 52: 98, 2024
APA
Luan, J., Liu, Y., Cao, M., Guo, X., & Guo, N. (2024). The pathogenic response of cytotoxic T‑lymphocytes, a common therapeutic target for cancer, has a direct impact on treatment outcomes (Review). Oncology Reports, 52, 98. https://doi.org/10.3892/or.2024.8757
MLA
Luan, J., Liu, Y., Cao, M., Guo, X., Guo, N."The pathogenic response of cytotoxic T‑lymphocytes, a common therapeutic target for cancer, has a direct impact on treatment outcomes (Review)". Oncology Reports 52.1 (2024): 98.
Chicago
Luan, J., Liu, Y., Cao, M., Guo, X., Guo, N."The pathogenic response of cytotoxic T‑lymphocytes, a common therapeutic target for cancer, has a direct impact on treatment outcomes (Review)". Oncology Reports 52, no. 1 (2024): 98. https://doi.org/10.3892/or.2024.8757