Open Access

Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review)

  • Authors:
    • Liucui Chen
    • Piaorong Zeng
    • Huifang Tang
    • Gang Chen
    • Juan Xie
    • Xiaoyan Yang
    • Xiaoyong Lei
  • View Affiliations

  • Published online on: August 28, 2024     https://doi.org/10.3892/or.2024.8805
  • Article Number: 146
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute myeloid leukemia (AML) is a predominant form of leukemia. Central nervous system (CNS) involvement complicates its diagnosis due to limited diagnostic tools, as well as its treatment due to inadequate therapeutic methodologies and poor prognosis. Furthermore, its incidence rate is unclear. The mechanisms of AML cell mobilization from the bone marrow (BM) to the CNS are not fully elucidated, and the molecular factors contributing to CNS infiltration are insufficiently recognized. The present review aimed to enhance the understanding of CNS involvement of AML and its impact on CNS. The latest research on the pathways and mechanisms facilitating AML cells to escape the BM and infiltrate the CNS was reviewed. Additionally, novel therapeutic strategies targeting specific molecules and genes for treating CNS involvement in AML were examined.
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November-2024
Volume 52 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Chen L, Zeng P, Tang H, Chen G, Xie J, Yang X and Lei X: Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review). Oncol Rep 52: 146, 2024.
APA
Chen, L., Zeng, P., Tang, H., Chen, G., Xie, J., Yang, X., & Lei, X. (2024). Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review). Oncology Reports, 52, 146. https://doi.org/10.3892/or.2024.8805
MLA
Chen, L., Zeng, P., Tang, H., Chen, G., Xie, J., Yang, X., Lei, X."Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review)". Oncology Reports 52.5 (2024): 146.
Chicago
Chen, L., Zeng, P., Tang, H., Chen, G., Xie, J., Yang, X., Lei, X."Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review)". Oncology Reports 52, no. 5 (2024): 146. https://doi.org/10.3892/or.2024.8805