Nucleolar casein kinase 2 alpha as a prognostic factor in patients with surgically resected early‑stage lung adenocarcinoma

  • Authors:
    • Satoshi Muto
    • Miwako Kato Homma
    • Yuichiro Kiko
    • Yuki Ozaki
    • Masayuki Watanabe
    • Naoyuki Okabe
    • Kazuyuki Hamada
    • Yuko Hashimoto
    • Hiroyuki Suzuki
  • View Affiliations

  • Published online on: November 6, 2024     https://doi.org/10.3892/or.2024.8837
  • Article Number: 4
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Abstract

Lung cancer remains a leading cause of global cancer‑related deaths, therefore the identification of prognostic factors for lung cancer is critical. Casein kinase 2 alpha (CK2α) is one of the driver kinases in various cancers, and it was previously demonstrated that CK2α localization was associated with a poor prognosis in invasive breast cancer. In the present study, the importance of CK2α in the nucleolus was explored as a potential prognostic marker for surgically resected early‑stage lung adenocarcinoma. The present study included 118 patients who underwent pulmonary lobectomy between 2014 and 2018 in Fukushima Medical University Hospital (Fukushima, Japan), and in whom CK2α localization in tumor samples was assessed by immunohistochemistry. Patient and tumor characteristics, including pathological stage, histological type and histological grade, were analyzed. Recurrence‑free survival (RFS) and overall survival were evaluated in relation to nucleolar CK2α staining. CK2α staining in the nucleoli was observed in 50.8% of lung adenocarcinoma tumors. Positive nucleolar CK2α staining was independent of pathological stage, histological type and histological grade. Patients with positive nucleolar CK2α staining exhibited significantly worse RFS compared with patients with negative staining. Multivariate analysis identified nucleolar CK2α staining and lymph node metastasis as independent poor prognostic factors. The results of the present study suggested that nucleolar CK2α staining is a novel and independent prognostic factor in surgically resected early‑stage lung adenocarcinoma. These findings indicated the potential of nucleolar CK2α as a predictive biomarker for future recurrence, and a guide to treatment decisions. Further research is required, particularly in understanding the molecular mechanisms linking nucleolar CK2α to recurrence.
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January-2025
Volume 53 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Muto S, Homma MK, Kiko Y, Ozaki Y, Watanabe M, Okabe N, Hamada K, Hashimoto Y and Suzuki H: Nucleolar casein kinase 2 alpha as a prognostic factor in patients with surgically resected early‑stage lung adenocarcinoma. Oncol Rep 53: 4, 2025.
APA
Muto, S., Homma, M.K., Kiko, Y., Ozaki, Y., Watanabe, M., Okabe, N. ... Suzuki, H. (2025). Nucleolar casein kinase 2 alpha as a prognostic factor in patients with surgically resected early‑stage lung adenocarcinoma. Oncology Reports, 53, 4. https://doi.org/10.3892/or.2024.8837
MLA
Muto, S., Homma, M. K., Kiko, Y., Ozaki, Y., Watanabe, M., Okabe, N., Hamada, K., Hashimoto, Y., Suzuki, H."Nucleolar casein kinase 2 alpha as a prognostic factor in patients with surgically resected early‑stage lung adenocarcinoma". Oncology Reports 53.1 (2025): 4.
Chicago
Muto, S., Homma, M. K., Kiko, Y., Ozaki, Y., Watanabe, M., Okabe, N., Hamada, K., Hashimoto, Y., Suzuki, H."Nucleolar casein kinase 2 alpha as a prognostic factor in patients with surgically resected early‑stage lung adenocarcinoma". Oncology Reports 53, no. 1 (2025): 4. https://doi.org/10.3892/or.2024.8837