Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review)

  • Authors:
    • Ying Xiong
    • Yi-Fan Liu
    • Zhi-Hui Yang
    • Cong-Gai Huang
  • View Affiliations

  • Published online on: December 27, 2024     https://doi.org/10.3892/or.2024.8860
  • Article Number: 27
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Abstract

Esophageal cancer (ESCA) is a common tumor noted in the digestive tract, which is highly malignant due to unclear early symptoms and poor last‑stage treatment effects; its mortality rate is relatively high. MicroRNA (miR) and signal transducer and activator of transcription 3 (STAT3) are key components of cellular signaling pathways; their interaction forms a complex and intricate information network that controls several types of biological behaviors in the cells. In the tumor cell, these signal transduction pathways are abnormally active, indicating that the STAT3 signaling pathway mediated by miRs is involved in the progression of various cancer types. The present review introduces the biological characteristics of miR and STAT3 and their relationship with ESCA. It summarizes the regulation of ESCA by the miR and STAT3 signaling pathways and analyzes the effects of these pathways on proliferation, apoptosis, invasion, metastasis and immune escape of cancer cells, as well as the impact on patient survival and prognosis. The purpose of the present review is to assess the miR/STAT3 signaling pathway in ESCA, improve the understanding of the pathogenesis of ESCA and facilitate the identification of therapeutic targets for ESCA.
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February-2025
Volume 53 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Xiong Y, Liu Y, Yang Z and Huang C: Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review). Oncol Rep 53: 27, 2025.
APA
Xiong, Y., Liu, Y., Yang, Z., & Huang, C. (2025). Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review). Oncology Reports, 53, 27. https://doi.org/10.3892/or.2024.8860
MLA
Xiong, Y., Liu, Y., Yang, Z., Huang, C."Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review)". Oncology Reports 53.2 (2025): 27.
Chicago
Xiong, Y., Liu, Y., Yang, Z., Huang, C."Impact of miRNAs involved in the STAT3 signaling pathway on esophageal cancer (Review)". Oncology Reports 53, no. 2 (2025): 27. https://doi.org/10.3892/or.2024.8860