Role of long noncoding RNAs in the regulation of epithelial‑mesenchymal transition in osteosarcoma (Review)
- Authors:
- Zihan Li
- Yihao Tian
-
Affiliations: Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Pathology, General Hospital of Northern Theater Command, Beifang Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China - Published online on: January 21, 2025 https://doi.org/10.3892/or.2025.8868
- Article Number: 35
-
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
|
Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, et al: Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations. Clin Cancer Res. 25:6346–6356. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Matsuoka K, Bakiri L, Wolff LI, Linder M, Mikels-Vigdal A, Patiño-García A, Lecanda F, Hartmann C, Sibilia M and Wagner EF: Wnt signaling and Loxl2 promote aggressive osteosarcoma. Cell Res. 30:885–901. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Gambera S, Abarrategi A, González-Camacho F, Morales-Molina Á, Roma J, Alfranca A and García-Castro J: Clonal dynamics in osteosarcoma defined by RGB marking. Nat Commun. 9:39942018. View Article : Google Scholar : PubMed/NCBI | |
|
Arvanitis C, Bendapudi PK, Tseng JR, Gambhir SS and Felsher DW: (18)F and (18)FDG PET imaging of osteosarcoma to non-invasively monitor in situ changes in cellular proliferation and bone differentiation upon MYC inactivation. Cancer Biol Ther. 7:1947–1951. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Asano N, Matsuzaki J, Ichikawa M, Kawauchi J, Takizawa S, Aoki Y, Sakamoto H, Yoshida A, Kobayashi E, Tanzawa Y, et al: A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes. Nat Commun. 10:12992019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu H, Li P, Chen L, Jian C, Li Z and Yu A: MicroRNAs as a novel class of diagnostic biomarkers for the detection of osteosarcoma: A meta-analysis. Onco Targets Ther. 10:5229–5236. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xia WK, Lin QF, Shen D, Liu ZL, Su J and Mao WD: Clinical implication of long noncoding RNA 91H expression profile in osteosarcoma patients. Onco Targets Ther. 9:4645–4652. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao-Long M, Kun-Peng Z and Chun-Lin Z: Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma. J Cancer. 9:1856–1862. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Liu C, Yang Z, Wu J, Zhang L, Lee S, Shin DJ, Tran M and Wang L: Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis. Hepatology. 67:1768–1783. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sztuba-Solinska J, Rausch JW, Smith R, Miller JT, Whitby D and Le Grice SFJ: Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: A structural scaffold for nuclear, cytoplasmic and viral proteins. Nucleic Acids Res. 45:6805–6821. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, et al: An integrated genome-wide CRISPRa approach to functionalize lncRNAs in drug resistance. Cell. 173:649–664.e20. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wright MW: A short guide to long non-coding RNA gene nomenclature. Hum Genomics. 8:72014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Ding W, Yu W, Zhang Y, Ao X and Wang J: Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer. Mol Ther Oncolytics. 23:458–476. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Ao X, Wang Y, Li X and Wang J: Long non-coding RNA in gastric cancer: Mechanisms and clinical implications for drug resistance. Front Oncol. 12:8414112022. View Article : Google Scholar : PubMed/NCBI | |
|
Gao H, Hao G, Sun Y, Li L and Wang Y: Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process. Onco Targets Ther. 11:8001–8012. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Feng L, Wei W, Heng Z, Yantao H and Chunbo W: Knockdown of REV7 inhibits breast cancer cell migration and invasion. Oncol Res. 24:315–325. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ji M, Li Z, Lin Z and Chen L: Antitumor activity of the novel HDAC inhibitor CUDC-101 combined with gemcitabine in pancreatic cancer. Am J Cancer Res. 8:2402–2418. 2018.PubMed/NCBI | |
|
Zhong G, Lin Y, Wang X, Wang K, Liu J and Wei W: H19 knockdown suppresses proliferation and induces apoptosis by regulating miR-130a-3p/SATB1 in breast cancer cells. Onco Targets Ther. 13:12501–12513. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
McFaline-Figueroa JL, Hill AJ, Qiu X, Jackson D, Shendure J and Trapnell C: A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition. Nat Genet. 51:1389–1398. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lu W and Kang Y: Epithelial-Mesenchymal plasticity in cancer progression and metastasis. Dev Cell. 49:361–374. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Williams ED, Gao D, Redfern A and Thompson EW: Controversies around epithelial-mesenchymal plasticity in cancer metastasis. Nat Rev Cancer. 19:716–732. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Latil M, Nassar D, Beck B, Boumahdi S, Wang L, Brisebarre A, Dubois C, Nkusi E, Lenglez S, Checinska A, et al: Cell-type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition. Cell Stem Cell. 20:191–204.e5. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sun WW, Xu ZH, Lian P, Gao BL and Hu JA: Characteristics of circulating tumor cells in organ metastases, prognosis, and T lymphocyte mediated immune response. Onco Targets Ther. 10:2413–2424. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Shen J, Zhao J, Wang J, Shan T, Li J, Xu M, Chen X, Liu Y and Cao G: Magnolol suppresses pancreatic cancer development in vivo and in vitro via negatively regulating TGF-β/Smad signaling. Front Oncol. 10:5976722020. View Article : Google Scholar : PubMed/NCBI | |
|
Yoo YG, Christensen J and Huang LE: HIF-1α confers aggressive malignant traits on human tumor cells independent of its canonical transcriptional function. Cancer Res. 71:1244–1252. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Han G, Guo Q, Ma N, Bi W, Xu M, Jia J and Wang W: LncRNA BCRT1 facilitates osteosarcoma progression via regulating miR-1303/FGF7 axis. Aging. 13:15501–15510. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Sun MX, An HY, Sun YB, Sun YB and Bai B: LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway. J Orthop Surg Res. 17:5572022. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Zhou J, Zhang Y, Hu T and Sun Y: Long non-coding RNA HCG11 aggravates osteosarcoma carcinogenesis via regulating the microRNA-579/MMP13 axis. Int J Gen Med. 13:1685–1695. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao H, Wang Y, Hou W, Ding X and Wang W: Long non-coding RNA MALAT1 promotes cell proliferation, migration and invasion by targeting miR-590-3p in osteosarcoma. Exp Ther Med. 24:6722022. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Y, Jia X, Wang M and Deng Y: Long noncoding RNA MIR31HG abrogates the availability of tumor suppressor microRNA-361 for the growth of osteosarcoma. Cancer Manag Res. 11:8055–8064. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, Wei Y, Zhu H, Yu L, Zhu J, Han Q, Liu Z, Huang J, Zhu Y, Fan G, et al: LncRNA NDRG1 aggravates osteosarcoma progression and regulates the PI3K/AKT pathway by sponging miR-96-5p. BMC Cancer. 22:7282022. View Article : Google Scholar : PubMed/NCBI | |
|
Tan H and Zhao L: lncRNA nuclear-enriched abundant transcript 1 promotes cell proliferation and invasion by targeting miR-186-5p/HIF-1α in osteosarcoma. J Cell Biochem. 120:6502–6514. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Y, Li J, Xiao JK, Xiao L, Xu BW and Li C: The lncRNA NEAT1 promotes the epithelial-mesenchymal transition and metastasis of osteosarcoma cells by sponging miR-483 to upregulate STAT3 expression. Cancer Cell Int. 21:902021. View Article : Google Scholar : PubMed/NCBI | |
|
Li J, Zhang Y, Sun F, Zhang G, Pan XA and Zhou Q: Long noncoding RNA PCGEM1 facilitates tumor growth and metastasis of osteosarcoma by sponging miR-433-3p and targeting OMA1. Orthop Surg. 15:1060–1071. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
He F, Ding G, Jiang W, Fan X and Zhu L: Effect of tumor-associated macrophages on lncRNA PURPL/miR-363/PDZD2 axis in osteosarcoma cells. Cell Death Discov. 7:3072021. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang Z, Jiang C and Fang J: Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. Biochem Biophys Res Commun. 495:238–245. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Deng Y, Zhao F, Zhang Z, Sun F and Wang M: Long noncoding RNA SNHG7 promotes the tumor growth and epithelial-to-mesenchymal transition via regulation of miR-34a signals in osteosarcoma. Cancer Biother Radiopharm. 33:365–372. 2018.PubMed/NCBI | |
|
Zhu S, Liu Y, Wang X, Wang J and Xi G: lncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via Wnt/β-catenin signaling. Mol Ther Nucleic Acids. 22:957–970. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Bu J, Guo R, Xu XZ, Luo Y and Liu JF: LncRNA SNHG16 promotes epithelial-mesenchymal transition by upregulating ITGA6 through miR-488 inhibition in osteosarcoma. J Bone Oncol. 27:1003482021. View Article : Google Scholar : PubMed/NCBI | |
|
Cao J, Han X, Qi X, Jin X and Li X: TUG1 promotes osteosarcoma tumorigenesis by upregulating EZH2 expression via miR-144-3p. Int J Oncol. 51:1115–1123. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ma H, Su R, Feng H, Guo Y and Su G: Long noncoding RNA UCA1 promotes osteosarcoma metastasis through CREB1-mediated epithelial-mesenchymal transition and activating PI3K/AKT/mTOR pathway. J Bone Oncol. 16:1002282019. View Article : Google Scholar : PubMed/NCBI | |
|
Wen JF, Jiang YQ, Li C, Dai XK, Wu T and Yin WZ: LncRNA-XIST promotes the oxidative stress-induced migration, invasion, and epithelial-to-mesenchymal transition of osteosarcoma cancer cells through miR-153-SNAI1 axis. Cell Biol Int. 44:1991–2001. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu W, Long Q, Zhang L, Zeng D, Hu B, Zhang W, Liu S, Deng S and Chen L: Long non-coding RNA X-inactive specific transcript promotes osteosarcoma metastasis via modulating microRNA-758/Rab16. Ann Transl Med. 9:8412021. View Article : Google Scholar : PubMed/NCBI | |
|
Yao W, Hou J, Liu G, Wu F, Yan Q, Guo L and Wang C: LncRNA CBR3-AS1 promotes osteosarcoma progression through the network of miR-140-5p/DDX54-NUCKS1-mTOR signaling pathway. Mol Ther Oncolytics. 25:189–200. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Gui D and Cao H: Long non-coding RNA CDKN2B-AS1 promotes osteosarcoma by increasing the expression of MAP3K3 via sponging miR-4458. In Vitro Cell Dev Biol Anim. 56:24–33. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Lin J, Chen J, Gu W, Mao Y, Wang H, Zhang Y and Liu W: DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11. Life Sci. 254:1173922020. View Article : Google Scholar : PubMed/NCBI | |
|
Ning Y and Bai Z: DSCAM-AS1 accelerates cell proliferation and migration in osteosarcoma through miR-186-5p/GPRC5A signaling. Cancer Biomark. 30:29–39. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L: ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3. J Bone Oncol. 26:1003352021. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Zhang R, Cheng G, Xu R and Han X: Long non-coding RNA HOXA-AS2 promotes migration and invasion by acting as a ceRNA of miR-520c-3p in osteosarcoma cells. Cell Cycle. 17:1637–1648. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
He JW, Li DJ, Zhou JH, Zhu YL and Yu BQ: SP1-mediated upregulation of lncRNA LMCD1-AS1 functions a ceRNA for miR-106b-5p to facilitate osteosarcoma progression. Biochem Biophys Res Commun. 526:670–677. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu W, Liu P, Gao H, Wang X and Yan M: Long non-coding RNA PGM5-AS1 promotes epithelial-mesenchymal transition, invasion and metastasis of osteosarcoma cells by impairing miR-140-5p-mediated FBN1 inhibition. Mol Oncol. 14:2660–2677. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Tong CJ, Deng QC, Ou DJ, Long X, Liu H and Huang K: LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway. Aging (Albany NY). 13:20116–20130. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang R, Zhang Z, Zhong Z and Zhang C: Long-non-coding RNA RUSC1-AS1 accelerates osteosarcoma development by miR-101-3p-mediated Notch1 signalling pathway. J Bone Oncol. 30:1003822021. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Wang H, Tao GL, Chu TB, Wang YX and Liu L: LncRNA-TMPO-AS1 promotes apoptosis of osteosarcoma cells by targeting miR-329 and regulating E2F1. Eur Rev Med Pharmacol Sci. 24:11006–11015. 2020.PubMed/NCBI | |
|
Meng X, Zhang Z, Chen L, Wang X, Zhang Q and Liu S: Silencing of the long non-coding RNA TTN-AS1 attenuates the malignant progression of osteosarcoma cells by regulating the miR-16-1-3p/TFAP4 axis. Front Oncol. 11:6528352021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Z, Wang J, Zhang X, Ran B, Wen J and Zhang H: TYMSOS-miR-101-3p-NETO2 axis promotes osteosarcoma progression. Mol Cell Probes. 67:1018872022. View Article : Google Scholar : PubMed/NCBI | |
|
Liu X, Wang M, Zhang L and Huang L: LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b and miR-520e-mediated inhibition of RHOC signaling. Clinics (Sao Paulo). 78:1001432023. View Article : Google Scholar : PubMed/NCBI | |
|
Ma HZ, Wang J, Shi J, Zhang W and Zhou DS: LncRNA LINC00467 contributes to osteosarcoma growth and metastasis through regulating HMGA1 by directly targeting miR-217. Eur Rev Med Pharmacol Sci. 24:5933–5945. 2020.PubMed/NCBI | |
|
Zheng Y, Chen Z, Zhou Z, Xu X and Yang H: Silencing of long non-coding RNA LINC00607 Prevents tumor proliferation of osteosarcoma by acting as a sponge of miR-607 to downregulate E2F6. Front Oncol. 10:5844522020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou Y, Li X and Yang H: LINC00612 functions as a ceRNA for miR-214-5p to promote the proliferation and invasion of osteosarcoma in vitro and in vivo. Exp Cell Res. 392:1120122020. View Article : Google Scholar : PubMed/NCBI | |
|
Bai J, Zhang X, Jiang F, Shan H, Gao X, Bo L and Zhang Y: A feedback loop of LINC00665 and the wnt signaling pathway expedites osteosarcoma cell proliferation, invasion, and epithelial-mesenchymal transition. Orthop Surg. 15:286–300. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Liu W, Zhang Q, Shen K, Li K, Chang J, Li H, Duan A, Zhang S and Huang Y: Long noncoding RNA LINC00909 induces epithelial-mesenchymal transition and contributes to osteosarcoma tumorigenesis and metastasis. J Oncol. 2022:86609652022. View Article : Google Scholar : PubMed/NCBI | |
|
Li R, Ruan Q, Zheng J, Zhang B and Yang H: LINC01116 promotes doxorubicin resistance in osteosarcoma by epigenetically silencing miR-424-5p and inducing epithelial-mesenchymal transition. Front Pharmacol. 12:6322062021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang S and Chen R: LINC01140 regulates osteosarcoma proliferation and invasion by targeting the miR-139-5p/HOXA9 axis. Biochem Biophys Rep. 31:1013012022.PubMed/NCBI | |
|
Gu Z, Wu S, Wang J and Zhao S: Long non-coding RNA LINC01419 mediates miR-519a-3p/PDRG1 axis to promote cell progression in osteosarcoma. Cancer Cell Int. 20:1472020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang H and Zhang P: lncRNA-CASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelial- mesenchymal transition via the Wnt/β-catenin signaling pathway. Oncol Rep. 45:762021. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Tang Y, Xing W, Dong W and Wang Z: LncRNA, CRNDE promotes osteosarcoma cell proliferation, invasion and migration by regulating Notch1 signaling and epithelial-mesenchymal transition. Exp Mol Pathol. 104:19–25. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ding Q, Mo F, Cai X, Zhang W, Wang J, Yang S and Liu X: LncRNA CRNDE is activated by SP1 and promotes osteosarcoma proliferation, invasion, and epithelial-mesenchymal transition via Wnt/β-catenin signaling pathway. J Cell Biochem. 121:3358–3371. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Zhao Z, Zhang S, Li Z, Li D, Yang S, Zhang H, Zeng X and Liu J: LncRNA FAL1 is a negative prognostic biomarker and exhibits pro-oncogenic function in osteosarcoma. J Cell Biochem. 119:8481–8489. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li B, Ren P and Wang Z: Long non-coding RNA Ftx promotes osteosarcoma progression via the epithelial to mesenchymal transition mechanism and is associated with poor prognosis in patients with osteosarcoma. Int J Clin Exp Pathol. 11:4503–4511. 2018.PubMed/NCBI | |
|
Yang W, Shan Z, Zhou X, Peng L, Zhi C, Chai J, Liu H, Yang J and Zhang Z: Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo. Cancer Biomark. 23:589–601. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao W and Li L: SP1-induced upregulation of long non-coding RNA HCP5 promotes the development of osteosarcoma. Pathol Res Pract. 215:439–445. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang N, Meng X, Liu Y, Chen Y and Liang Q: LPS promote osteosarcoma invasion and migration through TLR4/HOTAIR. Gene. 680:1–8. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y and Ji F: lncRNA HOTTIP facilitates osteosarcoma cell migration, invasion and epithelial-mesenchymal transition by forming a positive feedback loop with c-Myc. Oncol Lett. 18:1649–1656. 2019.PubMed/NCBI | |
|
Fang D, Yang H, Lin J, Teng Y, Jiang Y, Chen J and Li Y: 17β-estradiol regulates cell proliferation, colony formation, migration, invasion and promotes apoptosis by upregulating miR-9 and thus degrades MALAT-1 in osteosarcoma cell MG-63 in an estrogen receptor-independent manner. Biochem Biophys Res Commun. 457:500–506. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Bai S, Li Y, Wang Y, Zhou G, Liu C, Xiong W and Chen J: Long non-coding RNA MINCR regulates the growth and metastasis of human osteosarcoma cells via Wnt/β-catenin signaling pathway. Acta Biochim Pol. 69:551–557. 2022.PubMed/NCBI | |
|
Shi C, Huang CM, Wang B, Sun TF, Zhu AX and Zhu YC: Pseudogene MSTO2P enhances hypoxia-induced osteosarcoma malignancy by upregulating PD-L1. Biochem Biophys Res Commun. 530:673–679. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y and Cheng C: Long noncoding RNA NEAT1 promotes the metastasis of osteosarcoma via interaction with the G9a-DNMT1-Snail complex. Am J Cancer Res. 8:81–90. 2018.PubMed/NCBI | |
|
Zhang X, Zhang Y, Mao Y and Ma X: The lncRNA PCAT1 is correlated with poor prognosis and promotes cell proliferation, invasion, migration and EMT in osteosarcoma. Onco Targets Ther. 11:629–638. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Xun C, Jiang D, Tian Z, Yunus A and Chen J: Long noncoding RNA plasmacytoma variant translocation gene 1 promotes epithelial-mesenchymal transition in osteosarcoma. J Clin Lab Anal. 35:e235872021. View Article : Google Scholar : PubMed/NCBI | |
|
Gao S, Guo J, Li F, Zhang K, Zhang Y, Zhang Y, Zhang Y and Guo Y: Long non-coding RNA lncTCF7 predicts poor prognosis and promotes tumor metastasis in osteosarcoma. Int J Clin Exp Pathol. 10:10918–10925. 2017.PubMed/NCBI | |
|
Huang Y, Xu YQ, Feng SY, Zhang X and Ni JD: LncRNA TDRG1 promotes proliferation, invasion and epithelial-mesenchymal transformation of osteosarcoma through PI3K/AKT signal pathway. Cancer Manag Res. 12:4531–4540. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu B, Jin X, Yang T, Zhang Y, Liu S, Wu L, Ying H and Wang Z: Upregulated lncRNA THRIL/TNF-α signals promote cell growth and predict poor clinical outcomes of osteosarcoma. Onco Targets Ther. 13:119–129. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Y, Zhang Y, Zhang J, Ma J, Xu X, Wang Y, Zhou Z, Jiang D, Shen S, Ding Y, et al: Silencing of HuR inhibits osteosarcoma cell epithelial-mesenchymal transition via AGO2 in association with long non-coding RNA XIST. Front Oncol. 11:6019822021. View Article : Google Scholar : PubMed/NCBI | |
|
Shi D, Wu F, Mu S, Hu B, Zhong B, Gao F, Qing X, Liu J, Zhang Z and Shao Z: LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway. J Exp Clin Cancer Res. 38:3752019. View Article : Google Scholar : PubMed/NCBI | |
|
Luo Y, Tao H, Jin L, Xiang W and Guo W: CDKN2B-AS1 exerts oncogenic role in osteosarcoma by promoting cell proliferation and epithelial to mesenchymal transition. Cancer Biother Radiopharm. 35:58–65. 2020.PubMed/NCBI | |
|
Cai L, Lv J, Zhang Y, Li J, Wang Y and Yang H: The lncRNA HNF1A-AS1 is a negative prognostic factor and promotes tumorigenesis in osteosarcoma. J Cell Mol Med. 21:2654–2662. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Zou Y, Wu J, Chen B, Luo C, Chen X, Shen H and Luo L: The long noncoding RNA ZEB2-AS1 contributes to proliferation and epithelial-to-mesenchymal transition of osteosarcoma. Cancer Biother Radiopharm. 38:596–603. 2020.PubMed/NCBI | |
|
Jiang Y and Luo Y: LINC01354 promotes osteosarcoma cell invasion by up-regulating integrin β1. Arch Med Res. 51:115–123. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu J, Ding R and Xu Y: Effects of long non-coding RNA SPRY4-IT1 on osteosarcoma cell biological behavior. Am J Transl Res. 8:5330–5337. 2016.PubMed/NCBI | |
|
Ye F, Tian L, Zhou Q and Feng D: LncRNA FER1L4 induces apoptosis and suppresses EMT and the activation of PI3K/AKT pathway in osteosarcoma cells via inhibiting miR-18a-5p to promote SOCS5. Gene. 721:1440932019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Y, Ren X, Yuan Y and Yuan BS: Downregulated lncRNA GAS5 and upregulated miR-21 lead to epithelial-mesenchymal transition and lung metastasis of osteosarcomas. Front Cell Dev Biol. 9:7076932021. View Article : Google Scholar : PubMed/NCBI | |
|
Ye K, Wang S, Zhang H, Han H, Ma B and Nan W: Long noncoding RNA GAS5 suppresses cell growth and epithelial-mesenchymal transition in osteosarcoma by regulating the miR-221/ARHI pathway. J Cell Biochem. 118:4772–4781. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng HL, Yang RZ, Xu WN, Liu T, Chen PB, Zheng XF, Li B, Jiang LS and Jiang SD: Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma. Aging. 12:18571–18587. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Fan H, Liu T, Tian H and Zhang S: TUSC8 inhibits the development of osteosarcoma by sponging miR-197-3p and targeting EHD2. Int J Mol Med. 46:1311–1320. 2020.PubMed/NCBI | |
|
Zhang R and Xia T: Long non-coding RNA XIST regulates PDCD4 expression by interacting with miR-21-5p and inhibits osteosarcoma cell growth and metastasis. Int J Oncol. 51:1460–1470. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou FC, Zhang YH, Liu HT, Song J and Shao J: LncRNA LINC00588 suppresses the progression of osteosarcoma by acting as a ceRNA for miRNA-1972. Front Pharmacol. 11:2552020. View Article : Google Scholar : PubMed/NCBI | |
|
Wan D, Qu Y, Zhang L, Ai S and Cheng L: The lncRNA LINC00691Functions as a ceRNA for miRNA-1256 to suppress osteosarcoma by regulating the expression of ST5. Onco Targets Ther. 13:13171–13181. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu L, Zheng M, Wang X, Gao Y and Gu Q: LncRNA NR_136400 suppresses cell proliferation and invasion by acting as a ceRNA of TUSC5 that is modulated by miR-8081 in osteosarcoma. Front Pharmacol. 11:6412020. View Article : Google Scholar : PubMed/NCBI | |
|
Ma L, Zhang L, Guo A, Liu LC, Yu F, Diao N, Xu C and Wang D: Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells. Pathol Res Pract. 215:1524122019. View Article : Google Scholar : PubMed/NCBI | |
|
Tian H, Tang L, Yang Z, Xiang Y, Min Q, Yin M, You H, Xiao Z and Shen J: Current understanding of functional peptides encoded by lncRNA in cancer. Cancer Cell Int. 24:2522024. View Article : Google Scholar : PubMed/NCBI | |
|
Yi Q, Feng J, Lan W, Shi H and Sun W and Sun W: CircRNA and lncRNA-encoded peptide in diseases, an update review. Mol Cancer. 23:2142024. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y: LncRNA-encoded peptides in cancer. J Hematol Oncol. 17:662024. View Article : Google Scholar : PubMed/NCBI | |
|
Pan J, Liu M, Duan X and Wang D: A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction. PLoS One. 18:e02864222023. View Article : Google Scholar : PubMed/NCBI |
