Open Access

Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)

  • Authors:
    • Hongxi Han
    • Aichao Du
    • Jinwen Li
    • Hongyan Han
    • Peng Feng
    • Yufeng Zhu
    • Xinlong Li
    • Guopeng Tian
    • Haijia Yu
    • Bo Zhang
    • Weiguo Liu
    • Guoqiang Yuan
  • View Affiliations

  • Published online on: February 27, 2025     https://doi.org/10.3892/or.2025.8881
  • Article Number: 48
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumour, characterised by high heterogeneity, aggressiveness and resistance to conventional therapies, leading to poor prognosis for patients. In recent years, with the rapid development of molecular biology and genomics technologies, significant progress has been made in understanding the molecular mechanisms of GBM. This has revealed a complex molecular network involving aberrant key signalling pathways, epigenetic alterations, interactions in the tumour microenvironment and regulation of non‑coding RNAs. Based on these molecular features, novel therapeutic strategies such as targeted therapies, immunotherapy and gene therapy are rapidly evolving and hold promise for improving the outcome of GBM. This review systematically summarises the advances in molecular mechanisms and therapeutic approaches for GBM. It aims to provide new perspectives for the precise diagnosis and personalised treatment of GBM, and to ultimately improve the prognosis of patients.
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April-2025
Volume 53 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Han H, Du A, Li J, Han H, Feng P, Zhu Y, Li X, Tian G, Yu H, Zhang B, Zhang B, et al: Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncol Rep 53: 48, 2025.
APA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y. ... Yuan, G. (2025). Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review). Oncology Reports, 53, 48. https://doi.org/10.3892/or.2025.8881
MLA
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53.4 (2025): 48.
Chicago
Han, H., Du, A., Li, J., Han, H., Feng, P., Zhu, Y., Li, X., Tian, G., Yu, H., Zhang, B., Liu, W., Yuan, G."Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)". Oncology Reports 53, no. 4 (2025): 48. https://doi.org/10.3892/or.2025.8881