The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice
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- Published online on: March 1, 1996 https://doi.org/10.3892/or.3.2.333
- Pages: 333-338
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Abstract
A protein preparation obtained from the Ehrlich ascites carcinoma (EAC) by acetone precipitation, water extraction and subsequent two-step alcohol fractionation reduced significantly EAC cell proliferation in vivo and in vitro. The preparation was found to contain a low molecular-weight growth-inhibitory activity, suppressing both DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. The approximate molecular weight of this inhibitory component(s) is about 300-500 Da, corresponding to oligopeptide molecule(s).