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The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release

  • Authors:
    • P Roby
    • M Page

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  • Published online on: March 1, 1996     https://doi.org/10.3892/or.3.2.375
  • Pages: 375-377
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

CXC chemokines are known to bind to their receptors on neutrophils and activate them through the N-terminal ELR box. In this study, we show that the C-terminal alpha helix of human MGSA does bind to neutrophils, but contrary to complete MGSA, is unable to promote enzyme release by neutrophils. These results raise the possibility of MGSA being a multi-functional molecule with various domains of activation.

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March 1996
Volume 3 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 3.8
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 8.5
  • CiteScore Rank: Q1: #74/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.719
  • SCImago Journal Rank (SJR): 0.864
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Spandidos Publications style
Roby P and Page M: The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release. Oncol Rep 3: 375-377, 1996.
APA
Roby, P., & Page, M. (1996). The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release. Oncology Reports, 3, 375-377. https://doi.org/10.3892/or.3.2.375
MLA
Roby, P., Page, M."The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release". Oncology Reports 3.2 (1996): 375-377.
Chicago
Roby, P., Page, M."The C-terminal part of human melanoma growth stimulating activity (MGSA/GRO alpha) binds to neutrophils but does not stimulate enzyme release". Oncology Reports 3, no. 2 (1996): 375-377. https://doi.org/10.3892/or.3.2.375