Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation

  • Authors:
    • M Endo
    • J Yokoyama
    • H Ikawa
    • K Watanabe
    • M Ueda
    • M Kitajima
    • A Kinoshita
    • Y Kurosawa
    • R Tanosaki
  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/or.3.3.519
  • Pages: 519-525
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Abstract

Sixteen consecutive stem cell transplantations (SCT) were performed after myeloablative chemotherapy in patients with high-risk solid tumors of childhood. Seven patients received autologous bone marrow transplantation (ABMT), seven received peripheral blood stem cell transplantation (PBSCT) and two received ABMT + PBSCT. The progression-free survival was similar in three types of transplants (57% ABMT, 43% PBSCT vs. 50% ABMT + PBSCT). The rate of relapse in site of distant organs was also similar (57% ABMT, 57% PBSCT vs. 50% ABMT + PBSCT). There was no statistically significant difference in the hematopoietic recovery time between each group. PBSCT group had a significantly fewer days of food intolerance and a lower morbidity than ABMT group. The disease-free survival was 71% for neuroblastoma, 50% for small round cell tumors and 25% for rhabdomyosarcoma. Post-SCT therapy for possible reinfused tumor cells should be mandatory to decrease the frequency of relapse.

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May 1996
Volume 3 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Endo M, Yokoyama J, Ikawa H, Watanabe K, Ueda M, Kitajima M, Kinoshita A, Kurosawa Y and Tanosaki R: Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation. Oncol Rep 3: 519-525, 1996.
APA
Endo, M., Yokoyama, J., Ikawa, H., Watanabe, K., Ueda, M., Kitajima, M. ... Tanosaki, R. (1996). Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation. Oncology Reports, 3, 519-525. https://doi.org/10.3892/or.3.3.519
MLA
Endo, M., Yokoyama, J., Ikawa, H., Watanabe, K., Ueda, M., Kitajima, M., Kinoshita, A., Kurosawa, Y., Tanosaki, R."Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation". Oncology Reports 3.3 (1996): 519-525.
Chicago
Endo, M., Yokoyama, J., Ikawa, H., Watanabe, K., Ueda, M., Kitajima, M., Kinoshita, A., Kurosawa, Y., Tanosaki, R."Treatment of high-risk solid tumors of childhood with myeloablative chemotherapy and autologous stem cell transplantation". Oncology Reports 3, no. 3 (1996): 519-525. https://doi.org/10.3892/or.3.3.519