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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 1996 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 1996 Volume 3 Issue 4

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Article

Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice

  • Authors:
    • S Crnalic
    • P Bergstrom
    • R Lofvenberg
    • R Henriksson
    • L Brostrom
  • View Affiliations / Copyright

    Affiliations: UMEA UNIV HOSP,DEPT ONCOL,S-90185 UMEA,SWEDEN.
  • Pages: 609-612
    |
    Published online on: July 1, 1996
       https://doi.org/10.3892/or.3.4.609
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Abstract

In order to evaluate and modify the radiosensitizing effect of carboplatin, amphotericin B (AmB) was given as pre-treatment to nude mice with bilateral subcutaneous human osteosarcoma xenografts. One of the two tumours in each animal was irradiated with a single dose of 12 Gy following treatment with AmB (5 mg kg(-1)), or carboplatin (20 mg kg(-1)), or AmB (5 mg kg(-1)) plus carboplatin (20 mg kg(-1)), respectively. Tumour growth was compared with non-treated tumours. A significant reduction of tumour growth was observed after irradiation. Carboplatin in itself reduced tumour growth and also added to the effect of radiation. An unexpected interaction was seen where AmB obviously decreased the effect of either carboplatin or radiation alone or the two given concomitantly. The presented results are contradictory to some earlier in vitro studies and imply that the interactive effect in general and especially with regard to AmB can not be universally applied to all experimental situations.

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Copy and paste a formatted citation
Spandidos Publications style
Crnalic S, Bergstrom P, Lofvenberg R, Henriksson R and Brostrom L: Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice. Oncol Rep 3: 609-612, 1996.
APA
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., & Brostrom, L. (1996). Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice. Oncology Reports, 3, 609-612. https://doi.org/10.3892/or.3.4.609
MLA
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., Brostrom, L."Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice". Oncology Reports 3.4 (1996): 609-612.
Chicago
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., Brostrom, L."Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice". Oncology Reports 3, no. 4 (1996): 609-612. https://doi.org/10.3892/or.3.4.609
Copy and paste a formatted citation
x
Spandidos Publications style
Crnalic S, Bergstrom P, Lofvenberg R, Henriksson R and Brostrom L: Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice. Oncol Rep 3: 609-612, 1996.
APA
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., & Brostrom, L. (1996). Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice. Oncology Reports, 3, 609-612. https://doi.org/10.3892/or.3.4.609
MLA
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., Brostrom, L."Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice". Oncology Reports 3.4 (1996): 609-612.
Chicago
Crnalic, S., Bergstrom, P., Lofvenberg, R., Henriksson, R., Brostrom, L."Interaction between amphotericin B, carboplatin, and radiation in human osteosarcoma xenografts in nude mice". Oncology Reports 3, no. 4 (1996): 609-612. https://doi.org/10.3892/or.3.4.609
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