Detection of hepatitis B virus genome in hepatocellular carcinoma from both hepatitis B surface antigen- and antibody to hepatitis C virus-negative patients
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- Published online on: July 1, 1996 https://doi.org/10.3892/or.3.4.619
- Pages: 619-623
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Abstract
Twenty-two patients who tested seronegative for both hepatitis B virus (HBV) and hepatitis C virus (HCV) markers and undefined pathogenesis of hepatocellular carcinoma (HCC) were studied using polymerase chain reaction (PCR). Among these patients, 5 (23%) were positive for HBV-DNA in serum by PCR, but no patient was positive for HCV-RNA by reverse transcription PCR. Liver tissue specimens were available for analyzing HBV genome by PCR in 17 patients, and HBV sequences were detected in 10 (59%) patients. These results indicate that HBV is commonly implicated in serologically undefined pathogenesis of HCC in Japan.
